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Desestret V Ciccarino P Ducray F Crinière E Boisselier B Labussière M Polivka M Idbaih A Kaloshi G von Deimling A Hoang-Xuan K Delattre JY Mokhtari K Sanson M 《Journal of neuro-oncology》2011,105(2):219-224
Gliomatosis cerebri (GC) constitutes a heterogeneous group of conditions involving diffuse neoplastic glial cell infiltration of the brain. Management is difficult and an obvious challenge is to identify prognostic factors. Alpha-internexin (INA) expression, which is closely related to the 1p19q codeletion, is a strong prognostic marker in oligodendroglial tumors. Similarly, the R132H isocitrate dehydrogenase 1 IDH1 mutation, which can now be detected by use of a specific antibody, predicts better outcome in gliomas. In a retrospective series of 40 GC treated with up-front chemotherapy, we analyzed IDH1(R132H) mutant protein and INA immunohistochemical expression and correlated it with outcome; 17/40 GC expressed IDH1(R132H) and 10/40 GC expressed INA. IDH1(R132H) staining was strongly related to progression-free survival (42.3 vs. 15.5 months for positive IDH1(R132H) vs. negative tumors; P < 0.0001) and overall survival (73.9 vs. 23.6 months; P < 0.0001). This effect was independent of grade, histologic subtype, and INA expression (P < 0.001). Combined expression of IDH1(R132H) and INA was strongly associated with response to chemotherapy (100% vs. 36%; P = 0.003). These data strongly suggest that INA and IDH1(R132H) mutant protein immunohistochemical analysis is of a great prognostic value in biopsied GC. 相似文献
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Joubert Bastien Belbezier Aude Haesebaert Julie Rheims Sylvain Ducray François Picard Géraldine Rogemond Véronique Psimaras Dimitri Berzero Giulia Desestret Virginie Honnorat Jérôme 《Journal of neurology》2020,267(7):2083-2089
Journal of Neurology - To assess the long-term outcomes of patients with temporal lobe epilepsy and CSF anti-glutamate decarboxylase antibodies (GAD65-Abs). We retrospectively analyzed the clinical... 相似文献
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Lardeux Pierre Fourier Anthony Peter Elise Dorey Aline Muñiz-Castrillo Sergio Vogrig Alberto Picard Géraldine Rogemond Véronique Verdurand Mathieu Formaglio Maité Joubert Bastien Froment Tilikete Caroline Honnorat Jérôme Quadrio Isabelle Desestret Virginie 《Journal of neurology》2022,269(1):377-388
Journal of Neurology - To compare CSF biomarkers’ levels in patients suffering from anti-Leucine-rich Glioma-Inactivated 1 (LGI1) encephalitis to neurodegenerative [Alzheimer’s disease... 相似文献
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Jean-Christophe Brisset Monica Sigovan Fabien Chauveau Adrien Riou Emilie Devillard Virginie Desestret Monique Touret Serge Nataf J. Honnorat Emmanuelle Canet-Soulas Norbert Nighoghossian Yves Berthezene Marlene Wiart 《Molecular imaging and biology》2011,13(4):672-678
Purpose
To quantify small amounts of iron-labeled cells in mouse brains with magnetic resonance imaging (MRI).Procedures
Iron-labeled cells (from 500 to 7,500) were stereotaxically transplanted into the brain of living mice that were subsequently imaged with MRI at 4.7 T. We compared four quantitative methods: (1) T2 relaxometry, (2) T2* relaxometry, (3) the volume of the cloverleaf hypointense artifact generated on T2*-weighted images, and (4) the volume of the cloverleaf hyperintense artifact generated on positive contrast images.Results
The methods based on relaxometry, whether T2 or T2*, did not correlate with the number of injected cells. By contrast, those based on measurement of cloverleaf artifact volume, whether using negative or positive enhancement, showed a significant linear relationship for the given range of cells (R [0.92?C0.95], p?<?0.05).Conclusions
T2* artifact volume imaging (negative or positive) appears promising for the quantification of magnetically labeled cells following focal injection in the brain. 相似文献10.
J.-C. Brisset V. Desestret S. Marcellino E. Devillard F. Chauveau F. Lagarde S. Nataf N. Nighoghossian Y. Berthezene M. Wiart 《European radiology》2010,20(2):275-285