全文获取类型
收费全文 | 2496篇 |
免费 | 116篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 52篇 |
妇产科学 | 92篇 |
基础医学 | 348篇 |
口腔科学 | 36篇 |
临床医学 | 169篇 |
内科学 | 408篇 |
皮肤病学 | 28篇 |
神经病学 | 334篇 |
特种医学 | 52篇 |
外科学 | 336篇 |
综合类 | 5篇 |
预防医学 | 344篇 |
眼科学 | 27篇 |
药学 | 224篇 |
中国医学 | 2篇 |
肿瘤学 | 163篇 |
出版年
2021年 | 48篇 |
2020年 | 14篇 |
2019年 | 29篇 |
2018年 | 48篇 |
2017年 | 41篇 |
2016年 | 48篇 |
2015年 | 51篇 |
2014年 | 72篇 |
2013年 | 80篇 |
2012年 | 161篇 |
2011年 | 167篇 |
2010年 | 89篇 |
2009年 | 73篇 |
2008年 | 136篇 |
2007年 | 165篇 |
2006年 | 153篇 |
2005年 | 170篇 |
2004年 | 155篇 |
2003年 | 140篇 |
2002年 | 139篇 |
2001年 | 36篇 |
2000年 | 36篇 |
1999年 | 27篇 |
1998年 | 25篇 |
1997年 | 21篇 |
1996年 | 11篇 |
1993年 | 9篇 |
1992年 | 24篇 |
1991年 | 25篇 |
1990年 | 20篇 |
1989年 | 14篇 |
1988年 | 20篇 |
1987年 | 23篇 |
1986年 | 19篇 |
1985年 | 24篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1979年 | 24篇 |
1978年 | 17篇 |
1977年 | 9篇 |
1976年 | 15篇 |
1975年 | 22篇 |
1974年 | 18篇 |
1973年 | 20篇 |
1972年 | 11篇 |
1969年 | 10篇 |
1968年 | 11篇 |
1932年 | 9篇 |
1931年 | 12篇 |
排序方式: 共有2628条查询结果,搜索用时 625 毫秒
1.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
2.
3.
4.
5.
The authors described a 7 weeks old cervical pregnant case, whome was administered 250 mg methotrexate in infusion to eliminate the throphoblastic tissue. 3 days later the HCG was negative in the urine. After the dilatation of cervix by laminaria, the collapsed amniotic sac came from the cervix with minimal hemorrhage. They suggest the method is suitable to prevent the serious complications of cervical pregnancy. 相似文献
6.
T Juhás 《Ceskoslovenská oftalmologie》1990,46(5):367-370
Based on repeated fluoroangiographic examinations in a group of 28 children with type I diabetes mellitus the authors observed progressing diabetic retinal changes. At the end of the three-year observation period they found progress in 32% of the children. They investigated influence of risk factors such as age, duration of the basic disease, its metabolic compensation, sex and HLA typing on the development of diabetic retinopathy. 相似文献
7.
J Strausz S Kis J Juhász A Bede J Elek Z Monostori G Nagy I Repa 《Orvosi hetilap》1992,133(36):2293-2296
Six patients with obstruction of the trachea were treated with silicone rubber endothracheal stents implanted with flexible bronchoscope. In every case the stent caused significant clinical improvement of the ventilation. At the postintubation stenosis the stent can result a final recovery, at the malignant processes the implantation seems to be a new palliative method. 相似文献
8.
9.
10.
During a period of thirty years (1959-1989) 374 patients underwent surgery for differentiated thyroid carcinoma at the 1st Department of Surgery of the University Medical School in Debrecen. Distant metastases were found in the lungs or bones in 36 patients (9.6%). In 20 patients the first clinical sign of the primary disease was the distant metastasis. The aspects of surgical treatment depended on whether the metastases were solitary or multiple, capable or uncapable of radioiodine uptake. Whereas the majority of pulmonary metastases respond well to 131I-treatment the therapy of bone metastases is multidisciplinary. The 5-year survival rate was 47%, the 10-year one 19%. 相似文献