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1.
Karahan ZC Atalay F Uzun M Erturan Z Atasever M Akar N 《Microbial drug resistance (Larchmont, N.Y.)》2004,10(4):325-333
Drug-resistant tuberculosis is a serious problem throughout the world. Resistance to Rifampicin (RIF) is mainly caused by the mutations in the rpoB gene coding the beta-subunit of RNA polymerase. In this study, we aimed to detect the distribution of rpoB gene mutations in 80 RIF-resistant clinical Mycobacterium tuberculosis (MTB) isolates from Turkey. The rpoB gene was amplified by PCR and mutations leading to RIF resistance were determined by automated sequence analysis. A total of 72 of the 80 isolates (90%) were found to carry mutations in the amplified region, whereas eight isolates (10%) carried no mutations. Overall, 24 different missense mutations affecting 14 codons, and two deletion mutants were identified. Nine new mutations, six in the hot-spot region and three outside this region, were found. The codon numbers of the most frequently encountered mutations were 531 (51.4%), 526 (18.1%), 516 (13.9%), and 513 (12.5%). As a result, 90% of the RIF-resistant MTB isolates from the Turkish patients were found to carry a mutation in the rpoB gene, Ser531Leu being the most frequent one. Although molecular methods identify mutations leading to RIF resistance very quickly, results of the antimycobacterial susceptibility tests must be taken into consideration for the patients carrying no mutations in this region. 相似文献
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Ceren Orhan Ozgun Kaya Kara Serap Kaya Turkan Akbayrak Mintaze Kerem Gunel Gül Baltaci 《Disability and rehabilitation》2018,40(1):10-20
Purpose: The aim of this study was to investigate the effects of connective tissue manipulation (CTM) and Kinesio Taping® (KT) on constipation and quality of life in children with cerebral palsy (CP).Method: This study was designed as a randomized controlled trial. Forty children diagnosed with chronic constipation based on Rome III criteria were randomly assigned to CTM group [6 females, 7 males; 8 y 6?mo (SD = 3y 4?mo)], KT group [7 female, 7 male; 8y 7?mo (SD =3y 5?mo)] or control group [6 female, 7 male; 8y 3?mo (SD = 3y 6?mo)]. All patients were assessed with 7-day bowel diaries, Bristol Stool Form Scale (BSFS), Visual Analog Scale (VAS), and Pediatric Quality of Life Inventory (PEDsQL). Kruskal-Wallis, Wilcoxon’s signed-rank, and Mann–Whitney U tests were used to determine intra-group and inter-group differences. The level of significance was p?0.05.Results: Among the CTM, KT, and control groups, there were statistically significant differences regarding the changes in defecation frequency (2.46, 3.00, 0.30, ES 1.16, p?0.001), duration of defecation (5.07, 5.35, 0.15, ES 2.37, p?=?0.003), BSFS (1.84, 2.14, 0.07, ES 0.91, p?0.001), VAS (4.83, 3.87, 0.23, ES 1.98, p?0.001), and PEDsQL total scores (7, 14, 8.36, ?0.85, ES 4.08, p?0.001).Conclusions: This study revealed that CTM and KT seem equally effective physiotherapy approaches for the treatment of pediatric constipation and these approaches may be added to bowel rehabilitation program.
- Implications for rehabilitation
CTM and KT have similar effectiveness in alleviating the constipation-related symptoms and improving quality of life in children with CP.
CTM and KT can be integrated into bowel rehabilitation programs.
Considering the characteristics of patients, these treatment options can be used as an alternative of each other by physiotherapists.
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Microalgae are photosynthetic organisms that produce valuable metabolites as a result of being constantly exposed to stress conditions such as high or low temperature, high salinity, osmotic pressure, photo-oxidation, and ultraviolet radiation. These valuable metabolites drew attention from cosmetic and cosmeceutical industries to be used in anti-aging, sunscreen, and skin whitening products. Microalgal secondary metabolites can have anti-blemish or anti-microbial effect; can also repair and heal skin, protect skin from UV damage, and prevent inflammation. Existing cosmetic products can be replaced by microalgae derived cosmetic products which are environment-friendly and safe which make them publicly important since people want to have products as natural as possible. Currently some microalgal derived products are commercially available and biotechnology of microalgae is getting more and more developed every day which will be resulted in more commercial products in short period of time. This review highlights the potential of microalgae species and, bioactive molecules derived by them in trending natural cosmetics with a special emphasis on application areas and production steps. 相似文献
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Rengin Çetin Güvenç Nurgül Ceran Tolga Sinan Güvenç Hacer Ceren Tokgöz Yalçin Velibey 《Journal of cardiac failure》2018,24(9):583-593
Background
Involvement of right-sided heart chambers (RSHCs) in patients infected with human immunodeficiency virus (HIV) is common and is usually attributed to pulmonary arterial or venous hypertension (PH). However, myocardial involvement in patients with HIV is also common and might affect RSHCs even in the absence of overt PH. Our aim was to define morphologic and functional alterations in RSHC in patients with HIV and without PH.Methods and Results
A total of 50 asymptomatic patients with HIV and 25 control subjects without clinical or echocardiographic signs for PH were included in the study. Transthoracic echocardiography was used to obtain measurements. Patients with HIV had significantly increased right ventricular end-diastolic diameter (RVEDD) and right ventricular free wall thickness (RVFWT), as well as increased right atrial area and pulmonary arterial diameter, compared with control subjects. After adjustment for age, sex, and body surface area, RVFWT (average 1.81 mm, 95% confidence interval [CI] 0.35–3.26 mm) and RVEDD (average 6.82 mm, 95% CI 2.40–11.24 mm) were significantly higher in subjects infected with HIV. More patients with right ventricular hypertrophy were on antiretroviral treatment, and RVFWT was on average 1.3 mm higher (95% CI 0.24–2.37 mm) in patients on antiretroviral treatment after adjustment for confounders.Conclusions
These findings suggest that alterations in RSHCs were present in patients with HIV without PH. 相似文献7.
Esra Akyüz ?zkan Ceren Canbey G?ret Zeynep Tu?ba ?zdemir Serdar Yan?k Meryem Do?an Aylin G?nülta? Ay?e Neslin Akkoca 《International journal of clinical and experimental pathology》2015,8(9):11543-11548
Background: Although primary bone tumors are relatively uncommon, they constitute the most important tumors in patients less than 20 years. We aimed to determine the frequencies of primary bone tumors and tumor-like lesions of bone and the anatomical sites of their occurrence. Methods: A retrospective review of histopathology reports of all bone specimens received in a private pathology laboratory in Istanbul between 2009 and 2015. Results: A total of 57 patients (aged 5 to 18 years) with a mean of 13.12 years were studied. Thirty five patients (61.4%) were males and 22 (38.6%) were females. Fifty five (94.4%) of the tumors were benign. Osteochondroma was the commonest tumor accounting for 31 cases (54.3%) followed by osteoid osteoma, 9 cases (15.7%). Chondrosarcoma observed in two patients and Ewing sarcoma in one patient as malignant tumors. Of the 57 bone tumors 13 (22.8%) occurred in the upper extremities, while 44 (77.2%) were in the lower extremities. Proximal humerus was the most commonly involved site in upper extremity tumors, with osteochondromas representing the most frequent type of tumor (4 patients; 7%). In the lower extremities again osteochondromas were the most common type of tumor (8 cases, 14%), with the femur being the most common site of involvement (18 patients, 31.5%). Of the patients with tumor-like lesions; four patients had fibrous dysplasia, 4 patients had non-ossified fibromas, 4 patients had simple bone cysts and 3 had aneurismal bone cyst. Conclusion: This study showed that primary bone tumors were mainly benign, settled predominantly in the lower extremities mostly in the femur with a male preponderance. Osteochondroma was the most common benign bone tumor. We didn’t observed osteosarcoma, which is the most frequent malignant bone tumor. 相似文献
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Ozturk Taylan Durmaz Engin Ceren Kaya Mahmut Yaman Aylin 《International ophthalmology》2021,41(6):2009-2018
International Ophthalmology - To evaluate the relationship of novel inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with retinopathy of prematurity... 相似文献