全文获取类型
收费全文 | 4830篇 |
免费 | 330篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 161篇 |
妇产科学 | 78篇 |
基础医学 | 651篇 |
口腔科学 | 70篇 |
临床医学 | 369篇 |
内科学 | 970篇 |
皮肤病学 | 155篇 |
神经病学 | 669篇 |
特种医学 | 305篇 |
外科学 | 409篇 |
综合类 | 20篇 |
预防医学 | 232篇 |
眼科学 | 58篇 |
药学 | 338篇 |
中国医学 | 21篇 |
肿瘤学 | 626篇 |
出版年
2023年 | 27篇 |
2022年 | 25篇 |
2021年 | 102篇 |
2020年 | 59篇 |
2019年 | 81篇 |
2018年 | 95篇 |
2017年 | 83篇 |
2016年 | 79篇 |
2015年 | 101篇 |
2014年 | 139篇 |
2013年 | 174篇 |
2012年 | 243篇 |
2011年 | 292篇 |
2010年 | 140篇 |
2009年 | 120篇 |
2008年 | 249篇 |
2007年 | 250篇 |
2006年 | 253篇 |
2005年 | 245篇 |
2004年 | 270篇 |
2003年 | 217篇 |
2002年 | 230篇 |
2001年 | 155篇 |
2000年 | 136篇 |
1999年 | 123篇 |
1998年 | 76篇 |
1997年 | 71篇 |
1996年 | 62篇 |
1995年 | 61篇 |
1994年 | 50篇 |
1993年 | 42篇 |
1992年 | 100篇 |
1991年 | 99篇 |
1990年 | 70篇 |
1989年 | 77篇 |
1988年 | 81篇 |
1987年 | 58篇 |
1986年 | 71篇 |
1985年 | 68篇 |
1984年 | 55篇 |
1983年 | 44篇 |
1982年 | 24篇 |
1981年 | 12篇 |
1979年 | 22篇 |
1978年 | 14篇 |
1974年 | 14篇 |
1973年 | 14篇 |
1971年 | 13篇 |
1969年 | 13篇 |
1968年 | 10篇 |
排序方式: 共有5180条查询结果,搜索用时 17 毫秒
1.
2.
Y. Kuroda H. Takashima A. Ikeda C. Endo R. Neshige R. Kakigi H. Shibasaki 《Journal of neurology》1991,238(6):309-314
Summary Fourteen patients with HTLV-1-associated myelopathy were treated with high-dose intravenous gammaglobulin (IVGG). Ten received 10 g/day of IVGG and 4 received 400 mg/kg of body-weight/day of IVGG for 5 consecutive days. Improvement of spastic paraparesis was observed in 10 within 7 days of the commencement of IVGG. The therapeutic effects were sustained for more than 3 weeks in some patients. There were no side effects. Analysis of factors of relevance to the clinical improvement with IVGG showed that the beneficial response was preferentially found in patients having a high CSF titre of anti-HTLV-I antibodies, a high CSF IgG level and a marked brain MRI abnormality. 相似文献
3.
Summary Cranial computed tomography (CT) of 108 cases with dilated lateral ventricles was reviewed to elucidate the relationship between focal vulnerability of developing brain and disproportional dilatation of lateral ventricles. CT findings of 108 cases with symmetrical dilatation of lateral ventricles were classified into three types by morphometry of lateral ventricles: anterior horn predominant type (31 cases), diffuse type (36 cases), posterior horn predominant type (41 cases). Posterior horn predominant type has a tendency to occur in congenital anomalies and premature brain damage, and anterior horn predominant type in infantile brain damage. This disproportional dilatation of anterior or posterior horns suggests a vulnerability of periventricular structure in developing brain. 相似文献
4.
Toshiaki Ishizuka Takemi Matsui Yasuhiro Okamoto Atsuko Ohta Michitaka Shichijo 《Cardiovascular therapeutics》2004,22(2):71-90
It is known that thromboxane A2 (TXA2) contributes to various diseases such as bronchial asthma, ischemic heart disease, cerebrovascular disorders and allergic rhinitis. A number of TXA2 synthase inhibitors and TXA2 receptor (TP receptor) antagonists have been developed to treat these diseases. Ramatroban (BAY u 3405) was developed as a potent TP receptor antagonist with excellent efficacy against allergic rhinitis in many animal models and patients. Recent studies also revealed that ramatroban can block the newly identified PGD2 receptor, chemoattractant receptor‐homologous molecule expressed on Th2 cells (CRTh2). PGD2 induces migration and degranulation of eosinophils through CRTh2 and contributes to late‐phase inflammation and cell damage. Accordingly, it was considered that ramatroban suppresses the late‐phase inflammation via TP receptor and CRTh2 blockade. In terms of the efficacy on vascular systems, it was revealed that ramatroban can suppress the expression of monocyte chemoattractant protein‐1 (MCP‐1) and adhesion molecules in endothelial cells and prevent exacerbation of inflammation by blocking these responses. According to our recent studies in hypercholesterolemic rabbits ramatroban prevents macrophage infiltration through MCP‐1 downregulation and neointimal formation after balloon injury and attenuates vascular response to acetylcholine. Therefore, ramatroban may be beneficial in the treatment of atherosclerosis. 相似文献
5.
Tetsuya Ozeki Shuji Beppu Takuto Mizoe Yuuki Takashima Hiroshi Yuasa Hiroaki Okada 《Journal of controlled release》2005,107(3):387-394
In this study, we used a novel 4-fluid nozzle spray drier to prepare composite microparticles of a water-insoluble drug, flurbiprofen (FP), and a water-soluble drug, sodium salicylate (SS), for the purpose of improving the water solubility of FP. An ethanol solution of FP and an aqueous SS solution were simultaneously introduced through different liquid passages in the 4-fluid nozzle spray drier and then spray-dried. Quantitative elemental analysis suggested that the FP/SS ratio in each composite microparticle was nearly the same as the formulation ratio. We also found that SS and FP exist in a low crystallinity state in the composite particles. Release of FP from dissolved composite microparticles was markedly improved because of an increase in the effective surface area following rapid dissolution of SS. This study shows that it is possible to prepare FP-SS composite microparticles using a 4-fluid nozzle spray drier in single process and that this can improve the ability of FP to dissolve in water. 相似文献
6.
7.
Toshifumi Gabata Osamu Matsui Masumi Kadoya Samon Miyata Mitsuo Fujimura Tsutomu Takashima 《Cardiovascular and interventional radiology》1995,18(5):327-329
Gross hemorrhage is the most serious complication of anticoagulant therapy. We report the discovery and treatment of a large pseudoaneurysm of the superior gluteal artery in one patient who had been receiving oral anticoagulant therapy. We diagnosed the pseudoaneurysm by contrast-enhanced computed tomography, and embolized the artery with stainless steel coils. The exact cause of the pseudoaneurysm remains unclear, however, minor trauma appears most likely. 相似文献
8.
K Tanaka Y Fukuuchi S Gomi S Takashima B Mihara T Shirai S Nogawa H Nozaki E Nagata 《Experimental neurology》1992,117(3):254-259
The alterations of second-messenger ligand binding and cerebral blood flow (CBF) were evaluated in the gerbil brain after 2-h unilateral common carotid artery occlusion. [3H]Forskolin (FK) and [3H]phorbol-12,13-dibutyrate (PDBu) were used as specific ligands for adenylate cyclase (AC) and protein kinase C (PKC) activity estimation, respectively. CBF was determined at the end of the experiment by the [14C]iodoantipyrine method. A quantitative autoradiographic method permitted simultaneous measurement of the three parameters in the same brain. The levels in the caudate-putamen, globus pallidus, and hippocampus were analyzed. The animals were divided into three groups: Group 1 with severe ischemia (CBF in the lateral nuclei of the thalamus (CBFt) less than 50 ml/100 g/min), Group 2 with mild ischemia (CBFt greater than or equal to 50 ml/100 g/min), and the Sham Group. The PDBu binding revealed a statistically significant increase in the caudate-putamen, lateral nuclei of the thalamus and hippocampus (CA1 and CA3 regions and dentate gyrus) on the ischemic side in Group 1 as compared to that in Group 2 and the Sham Group. In contrast, the FK binding did not show any significant changes in any of the regions. These data and our previous findings for 6-h ischemia suggest that (1) PKC translocation to the cell membrane may occur at the early ischemic phase in particular regions including the caudate-putamen, lateral nuclei of the thalamus and hippocampus, with the translocated PKC gradually diminishing during the subsequent ischemic period; and (2) the suppression of the AC system observed in 6-h ischemia may not appear in the early ischemic phase. 相似文献
9.
N Tonami K Yokoyama J Taki K Hisada Y Watanabe T Takashima A Nonomura 《Journal of nuclear medicine》1991,32(12):2284-2285
A case of radiologically occult lung cancer is presented in which 201TI SPECT of the chest clearly delineated the involved area. A 66-yr-old man underwent chest screening examinations for asymptomatic smokers and presented a positive sputum cytology for lung cancer. Conventional chest x-ray, tomography of computed radiography, and a CT scan failed to locate the lesion in the lung. Thallium-201 SPECT, however, was successful in depicting the area of the involvement. 相似文献
10.