全文获取类型
收费全文 | 733篇 |
免费 | 56篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 5篇 |
妇产科学 | 13篇 |
基础医学 | 99篇 |
口腔科学 | 13篇 |
临床医学 | 52篇 |
内科学 | 132篇 |
皮肤病学 | 8篇 |
神经病学 | 108篇 |
特种医学 | 75篇 |
外科学 | 76篇 |
综合类 | 6篇 |
预防医学 | 18篇 |
眼科学 | 132篇 |
药学 | 29篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 9篇 |
2022年 | 7篇 |
2021年 | 15篇 |
2020年 | 5篇 |
2019年 | 14篇 |
2018年 | 10篇 |
2017年 | 16篇 |
2016年 | 26篇 |
2015年 | 15篇 |
2014年 | 15篇 |
2013年 | 32篇 |
2012年 | 57篇 |
2011年 | 66篇 |
2010年 | 26篇 |
2009年 | 26篇 |
2008年 | 38篇 |
2007年 | 44篇 |
2006年 | 40篇 |
2005年 | 45篇 |
2004年 | 40篇 |
2003年 | 44篇 |
2002年 | 38篇 |
2001年 | 22篇 |
2000年 | 12篇 |
1999年 | 7篇 |
1998年 | 7篇 |
1997年 | 13篇 |
1996年 | 2篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1974年 | 2篇 |
1972年 | 2篇 |
1903年 | 7篇 |
1886年 | 1篇 |
排序方式: 共有791条查询结果,搜索用时 15 毫秒
1.
David Simon Koray Tascilar Sara Unbehend Sara Bayat Andreas Berlin Anna-Maria Liphardt Timo Meinderink Juergen Rech Axel J Hueber Georg Schett Arnd Kleyer 《Journal of bone and mineral research》2020,35(9):1695-1702
The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high-resolution peripheral quantitative computed tomography (HR-pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z-score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p < .001) (explained by an increase in cortical vBMD (Δz = 1.07, p = .02) and reduction in the trabecular vBMD (Δz = −0.07, p = .09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender-study group interaction (p = .044) explained by reduced trabecular vBMD in males (Δz = −1.23, p = .02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender-specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research. 相似文献
2.
The gene for the human interleukin-2 receptor 相似文献
3.
Tobias Engelhorn Sophia Goerike Arnd Doerfler Christine Okorn Michael Forsting Gerd Heusch Rainer Schulz 《Journal of cerebral blood flow and metabolism》2004,24(4):467-474
The goal of the present study was to test the impact of administration time of the angiotensin II type 1-receptor blocker candesartan on cerebral blood flow (CBF), infarct size, and neuroscore in transient cerebral ischemia. Therefore, 1-hour middle cerebral artery occlusion (MCAO) was followed by reperfusion. Rats received 0.5-mg/kg candesartan intravenously 2 hours before MCAO (pretreatment), 24 hours after MCAO, every 24 hours after MCAO, or 2 hours before and every 24 hours after MCAO. Infarct size (mm3) and a neuroscore at day 7 were compared with controls. CBF was quantified by radiolabeled microspheres and laser-Doppler flowmetry. Compared with controls (95 +/- 8), infarct size in candesartan-treated groups was smaller (59 +/- 5, 68 +/- 10, 28 +/- 3, and 15 +/- 3, respectively; P<0.05). Although there was no difference in neuroscore between pretreatment and controls (1.55 +/- 0.18, 1.80 +/- 0.13), other treatment regimens resulted in improved neuroscores (1.33 +/- 0.16, 1.11 +/- 0.11, 0.73 +/- 0.15; P<0.05). CBF in pretreated animals at 0.5 hours after MCAO was significantly higher than in controls (0.58 +/- 0.09 mL x g(-1) x min(-1) and 44% +/- 7% of baseline compared with 0.49 +/- 0.06 mL x g(-1) x min(-1) and 37% +/- 6%, microspheres and laser-Doppler flowmetry; P<0.05). Thus, candesartan reduces infarct size even if administered only during reperfusion. Apart from pretreatment, other treatment regimens result in significantly improved neuroscores. In the acute phase of cerebral ischemia, candesartan increases CBF. 相似文献
4.
Bart Jacobs Gary T. Leavens Peter Müller Arnd Poetzsch-Heffter 《Quality of life research》1995,4(5):387-506
Abstracts of the contributed papers 相似文献
5.
实验性单纯疱疹性角膜炎的组织病理学研究 总被引:1,自引:0,他引:1
目的:动态观察1型单纯疱疹病毒(HSV-1)感染角膜后的组织病理改变。方法:BALB/c小鼠眼角膜接种HSV-1(KOS株)以诱发单纯疱疹性角膜炎(HSK)。分别收集正常眼球及感染后第2、7、14天的感染眼球,组织学观察结膜及角膜的病理过程。结果:感染后第2天,中性粒细胞、淋巴细胞及其他单核细胞浸润结膜并在第7-14天间快速向中央角膜扩散。结论:在HSK发展中,中性粒细胞浸润导致进行性的组织破坏。 相似文献
6.
J Geisel B Weisshaar K Oette W Doerfler 《Zeitschrift für klinische Chemie und klinische Biochemie》1988,26(7):429-433
The existence of a new Apa LI restriction fragment length polymorphism in the third intron of the low density lipoprotein (LDL) receptor gene was described. As a gene probe we used a newly constructed derivative of pLDLR 3 which did not contain the highly repetitive Alu-sequences in exon 18. This new gene probe detected all exon sequences containing restriction fragments, and enabled us to demonstrate all described polymorphisms, which might be useful for genetic linkage studies. Based on analysis of 72 unrelated normo- and hypercholesterolaemic persons, the frequency of the allele A2, which showed the additional cutting site, was determined to be 0.05. With the simplified gene probe, pLDLR delta, we also studied other polymorphisms. A clear linkage disequilibrium between the Pvu II and Msp I polymorphisms was detected. This, and the previously described linkage disequilibrium of the two Msp I polymorphisms, demonstrate that the LDL receptor gene is apparently less heterogeneous than expected from the number of described polymorphisms. 相似文献
7.
8.
9.
10.