改良高频电针治疗腋臭症190例

2006年以来，我们采用改良高频电针治疗腋臭症190例，疗效满意。现分析报告如下。     

高压氧对大鼠脑外伤后脑组织IGF-1表达的影响

高压氧(hyperbaric oxygenation,HBO)治疗是指周期性吸入超过一个大气压纯氧的治疗.国内外大量临床及实验报道HBO对严重颅脑损伤具有治疗意义[1-4],但目前HBO的治疗作用效果与机制尚不完全清楚.     

高压氧舱内使用气控变压式多功能呼吸机1例

<正>1病例报告患者,女,83岁,因CO中毒昏迷2h,经120送入我院急诊ICU。入院查体:意识呈昏迷,GCS评分5分,T 36.1℃,HR 78次/min,BP 160/95mmHg,自主呼吸微弱。予气管插管呼吸机辅助呼吸,双侧瞳孔等大等圆,对光反应存在,唇无紫绀,面色潮红,角膜反射存     

高压氧治疗大鼠脑外伤后脑组织NF-κB(P50)表达的实验研究

目的 探讨高压氧对颅脑外伤的治疗作用及与脑组织中NF-κB(P50)表达之间的关系. 方法 120只SD大鼠按随机数字表法分为假手术组(仅开颅钻孔,不行打击)、外伤对照组(Feeney自由落体损伤模型制作法制造中度大鼠脑外伤模型,但不接受氧治疗)、常压氧治疗组(脑外伤模型制作成功后立即接受正常压力下纯氧吸入治疗)、高压氧治疗组(脑外伤模型制作成功后立即接受0.2 MPa压力下高压氧治疗),并于伤后6h、1 d、3 d、5 d、7 d五个时相点断头法取脑组织(每时相点6只),光镜下观察脑组织损伤水肿的病理变化以及采用免疫组化方法检测NF-κB(P50)在脑组织中的表达情况. 结果 高压氧干预使相同时相点高压氧治疗组大鼠脑水肿情况及损伤程度较外伤对照组明显减轻,而常压氧干预作用则不明显.假手术组各时相点仅见微量的NF-κB(P50)阳性表达或不表达,其他各组脑损伤后6 h即发现损伤脑组织内NF-κB(P50)阳性表达上调,且持续呈增高趋势,伤后5 d时达到最高值.高压氧治疗组与外伤对照组及常压氧治疗组相比在相同时相点NF-κB(P50)表达均有增强,差异有统计学意义(P<0.05). 结论 高压氧治疗对损伤神经细胞具有保护、修复的治疗作用,增加NF-κB(P50)在脑组织细胞中的表达可能是其神经保护途径之一.     

Expression of brain nuclear factor-κB (P50) in mice with traumatic brain injury after hyperbaric oxygen treatment

Objective To investigate the relation between the therapeutic effect of hyperbaric oxygen treatment and nuclear factor-κB (NF-κB) (P50) expression in the brain tissue in mice with traumatic brain injury (TBI). Methods A total of 120 SD rats were randomly divided into sham-operated, TBI model, normobaric oxygen and hyperbaric oxygen (0.2 MPa) groups, and in the latter 3 groups, TBI was induced using Feeney's method. At 6 h and 1, 3, 5, and 7 d following TBI (6 rats at each time point), the rats were sacrificed to observe the pathological changes in the brain tissues under light microscope and detect the expression of NF-κB (P50) using immunohistochemistry. Results The rats in hyperbaric oxygen group showed lessened brain edema as compared with those in TBI model and normobaric oxygen groups. Only trace amount of NF-κB (P50) expression was observed in the sham-operated group, while in the 3 groups with TBI, NF-κB (P50) expression began to increase as early as 6 h after TBI and kept increasing till reaching the peak level at 5 days. At each of the time points for observation, the expression ofNF-κB (PS0) in hyperbaric oxygen group was significantly higher than those in TBI and normobaric oxygen groups (P<0.05). Conclusion Hyperbaric oxygen treatment offers protection of the injured neural cells and promotes their repair in rats following TBI. Increased NF-κB (P50) expression in the brain tissue may serve as one of the pathways mediating the neuroprotective effect of hyperbaric oxygen treatment.     

高压氧治疗重度颅脑损伤患者的疗效观察

目的探讨常规治疗基础上加用高压氧（hyperbaric oxygen,HBO）治疗重度颅脑损伤的疗效。方法将重度颅脑损伤368例随机分为观察组和对照组各184例,观察高压氧治疗前后临床情况及预后。结果观察组临床（GCS评分）及预后评估（BI评分）均明显改善,而对照组改善不明显,差异具有统计学意义（P〈0.05）。结论高压氧治疗能够明显降低重度颅脑损伤患者病死率和病残率。