全文获取类型
收费全文 | 186篇 |
免费 | 12篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 9篇 |
基础医学 | 20篇 |
口腔科学 | 1篇 |
临床医学 | 9篇 |
内科学 | 32篇 |
皮肤病学 | 4篇 |
神经病学 | 18篇 |
特种医学 | 4篇 |
外科学 | 16篇 |
综合类 | 1篇 |
预防医学 | 14篇 |
眼科学 | 7篇 |
药学 | 19篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 4篇 |
2022年 | 1篇 |
2021年 | 13篇 |
2020年 | 11篇 |
2019年 | 9篇 |
2018年 | 11篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 15篇 |
2012年 | 25篇 |
2011年 | 21篇 |
2010年 | 1篇 |
2009年 | 6篇 |
2008年 | 11篇 |
2007年 | 10篇 |
2006年 | 6篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 2篇 |
2002年 | 5篇 |
排序方式: 共有198条查询结果,搜索用时 556 毫秒
1.
2.
Nishit J. Shah Mukul Navnit Chandrashekhar E. Deopujari Shraddha S. Mukerji 《Indian journal of otolaryngology and head and neck surgery》2004,56(1):71-78
Endonasal endoscopic surgery is now the preferred technique to tackle pituitary tumours. Our paper describes the stepwise
endoscopic approach for surgeons embarking on pituitary surgery. It also highlights the common pitfalls encountered during
surgery and the ways to avoid them. One must proceed in a gradual step- wise manner starting from simple exposure of the sphenoid
sinus to complete endoscopic tumour removal so us to gain the neurosurgeon’s confidence as well as develop our own skills,
confidence and ability to tackle complications. We use the endonasal paraseptal trans- sphenoidal approach. Surgery begins
with gentle packing between the middle turbinate and septum to expose the anterior sphenoid wall and expose the sphenoid astium.
The ostitum is then widened inferiorly and onto the opposite side to expose both sphenoid sinuses. The inter- sphenoid sinus
and necessary mucosa is removed to expose the sella. We then use a bone flap technique or punches to open the sella. After
incising the dura, tumour is removed with a suction curette. An endoscope holder facilitates the operation. The bone flap
is replaced at the end of surgery to reconstruct the sella. This is especially important if a CSF leak is present. Nasal packing
is usually not required. 相似文献
3.
Comorbidities in head and neck cancer: agreement between self-report and chart review. 总被引:1,自引:1,他引:0
Shraddha S Mukerji Sonia A Duffy Karen E Fowler Mumtaz Khan David L Ronis Jeffrey E Terrell 《Otolaryngology--head and neck surgery》2007,136(4):536-542
OBJECTIVES: To determine the accuracy of self-reported comorbidities compared with medical record review and the clinical and sociodemographic characteristics associated with accuracy of self-reported comorbidities. STUDY DESIGN: We conducted a prospective study of 458 newly diagnosed head and neck cancer patients using self-administered questionnaire and medical chart review data. Overall and itemwise consistency between self-report and chart review was evaluated. Social, clinical, and demographic characteristics of consistent versus inconsistent responders were analyzed. RESULTS: Seventy-four percent of patients had at least one comorbidity. There was good overall consistency between self-report and chart review (kappa = 0.50). Compared with consistent responders, inconsistent responders were found to be older (P < 0.05), have lower sleep (P < 0.05) and physical activity scores (P < 0.05), be more depressed (P < 0.05), and have more severe comorbidities (P < 0.05). CONCLUSIONS AND SIGNIFICANCE: Self-report may be considered as an alternative to chart review for comorbidity assessment in head and neck cancer patients. Younger patients, those with good general health, fewer depressive symptoms, and mild comorbidities, are more likely to give responses consistent with chart review. 相似文献
4.
5.
S. K. Vishwakarma Shraddha Jain Manisha Gupta 《Indian journal of otolaryngology and head and neck surgery》2006,58(1):87-88
Oral manifestation of tuberculosis is uncommon Tongue is the most common oral site of involvement, where the presentations
are varied. Here we report a case of primary lingual tuberculosis with an unusual presentation as a cold abscess. 相似文献
6.
Shraddha Rani Modapathi Anusha Rohit Vankadari Aditya Varsha Prakash Shetty Akshatha Kotian Praveen Rai Indrani Karunasagar Vijaya Kumar Deekshit 《Indian journal of medical microbiology》2022,40(1):74-80
PurposeBurkholderia is a Gram-negative opportunistic bacterium capable of causing severe nosocomial infections. The aim of this study was to characterize Burkholderia cepacia complex and to compare different molecular methods used in its characterization.MethodsIn this study, 45 isolates of Burkholderia cepacia complex (Bcc) isolated from clinical cases were subjected to RAPD (Random amplified polymorphic DNA), recA-RFLP (Restriction fragment length polymorphism), 16SrDNA-RFLP, whole-cell protein analysis, recA DNA sequencing and biofilm assay.ResultsOf the 45 isolates tested, 97.7% were sensitive to ceftazidime, 82.2% were sensitive to Cotrimoxazole, 73.3% were sensitive to meropenem, 55.5% were sensitive to minocycline and 42.2% were sensitive to levofloxacin. Majority of the isolates harbored all the tested virulence genes except bpeA and cblA. The RAPD generated 11 groups (R1-R11), recA-RFLP 10 groups (A1-A10), 16SrRNA-RFLP 5 groups (S1–S5) and SDS-PAGE (Sodium Dodecyl Sulphate-Polyacrylamide gel electrophoresis) whole cell protein analysis revealed 12 groups (C1–C12). recA sequencing revealed that most of the isolates belonging to the genomovar III Burkholderia cenocepacia. Though all the methods are found to be efficient in differentiating Burkholderia spp., recA-RFLP was highly discriminatory at 96% similarity value. The study also identified a new strain Burkholderia pseudomultivorans for the first time in the country. Further, recA sequencing could identify the strains to species level. Majority of the multidrug-resistant strains also showed moderate to strong biofilm-forming ability, which further contributes to the virulence characteristics of the pathogens.ConclusionsThe study highlights the importance of combination of molecular methods to characterize Burkholderia cepacia complex. Molecular typing of these human pathogens yields important information for the clinicians in order to initiate the most appropriate therapy in the case of severe infections and to implement preventive measures for the effective control of transmission of Burkholderia spp. 相似文献
7.
Shraddha Madanagobalane Sankarasubramanian Anandan 《Indian journal of dermatology》2013,58(4):316-Aug;58(4):316
8.
Shraddha K. Dahale S. K. Prashanthi P. U. Krishnaraj 《Proceedings of the National Academy of Sciences, India. Section B.》2016,86(3):723-734
The aim of the present study was to understand the mineral phosphate solubilization (MPS) in Rhizobium sp. MR-54 (MPS+) by using forward genetic approach and its effect on nodulation as well as nitrogen accumulation on green gram. Tn5 mutants (MPS?) were generated from the MPS+ strain by Tn5 mutagenesis. Screening 1,603 colonies of MR-54::Tn5 resulted in identification of those mutants which failed to show any solubilization zone up to 72 h after incubation on Tri-calcium phosphate medium (TCP). pH drops and Pi release were highly correlated up to 15 days after incubation in TCP broth. Gluconic acid was detected in the culture supernatants of MPS+ isolates through thin layer chromatography indicating the presence of direct oxidation pathway in MR-54 strain. Detailed characterization of mutants was carried out for related properties like colony morphology, Pi release and pH change in TCP broth, organic acid production, surface characteristics and plant growth promoting ability etc. Mutants deficient in MPS showed reduced nodulation and nitrogen accumulation in green gram under green house conditions in leonard jar apparatus over the wild strain indicating the MPS by Rhizobium being involved in nodulation, nitrogen accumulation and plant growth. 相似文献
9.
Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery. 总被引:1,自引:0,他引:1
Shraddha S Badve Praveen Sher Aruna Korde Atmaram P Pawar 《European journal of pharmaceutics and biopharmaceutics》2007,65(1):85-93
The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of diclofenac sodium intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. To overcome limitations of various approaches for imparting buoyancy, hollow/porous beads were prepared by simple process of acid-base reaction during ionotropic crosslinking. The floating beads obtained were porous (34% porosity), hollow with bulk density<1 and had Ft50% of 14-24 h. In vivo studies by gamma scintigraphy determined on rabbits showed gastroretention of beads up to 5 h. The floating beads provided expected two-phase release pattern with initial lag time during floating in acidic medium followed by rapid pulse release in phosphate buffer. This approach suggested the use of hollow calcium pectinate microparticles as promising floating-pulsatile drug delivery system for site- and time-specific release of drugs acting as per chronotherapy of diseases. 相似文献
10.
Khan MK Nigavekar SS Minc LD Kariapper MS Nair BM Lesniak WG Balogh LP 《Technology in cancer research & treatment》2005,4(6):603-613
Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics different from PAMAM dendrimers in a B16 mouse tumor model system. We review important chemical and biologic uses of these nanodevices and discuss the potential of nanocomposite devices to greatly improve cancer imaging and therapy, in particular radiation therapy. We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable. 相似文献