全文获取类型
收费全文 | 614篇 |
免费 | 34篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 20篇 |
妇产科学 | 2篇 |
基础医学 | 38篇 |
口腔科学 | 6篇 |
临床医学 | 104篇 |
内科学 | 169篇 |
皮肤病学 | 2篇 |
神经病学 | 27篇 |
特种医学 | 89篇 |
外科学 | 90篇 |
综合类 | 16篇 |
预防医学 | 29篇 |
眼科学 | 3篇 |
药学 | 25篇 |
肿瘤学 | 52篇 |
出版年
2023年 | 2篇 |
2021年 | 4篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 7篇 |
2015年 | 12篇 |
2014年 | 11篇 |
2013年 | 25篇 |
2012年 | 33篇 |
2011年 | 21篇 |
2010年 | 25篇 |
2009年 | 19篇 |
2008年 | 21篇 |
2007年 | 23篇 |
2006年 | 42篇 |
2005年 | 27篇 |
2004年 | 22篇 |
2003年 | 25篇 |
2002年 | 18篇 |
2001年 | 25篇 |
2000年 | 21篇 |
1999年 | 15篇 |
1998年 | 18篇 |
1997年 | 6篇 |
1996年 | 20篇 |
1995年 | 16篇 |
1994年 | 17篇 |
1993年 | 7篇 |
1992年 | 10篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 22篇 |
1988年 | 19篇 |
1987年 | 18篇 |
1986年 | 13篇 |
1985年 | 16篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1955年 | 2篇 |
1954年 | 2篇 |
1943年 | 2篇 |
排序方式: 共有674条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Sheppard FR Kelher MR Moore EE McLaughlin NJ Banerjee A Silliman CC 《Journal of leukocyte biology》2005,78(5):1025-1042
The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs) to eradicate invading pathogens. The production of a superoxide anion (O2-) into the phagolysosome is the precursor for the generation of more potent products, such as hydrogen peroxide and hypochlorite. However, this production of O2- is dependent on translocation of the oxidase subunits, including gp91phox, p22phox, p47phox, p67phox, p40phox, and Rac2 from the cytosol or specific granules to the plasma membrane. In response to an external stimuli, PMNs change from a resting, nonadhesive state to a primed, adherent phenotype, which allows for margination from the vasculature into the tissue and chemotaxis to the site of infection upon activation. Depending on the stimuli, primed PMNs display altered structural organization of the NADPH oxidase, in that there is phosphorylation of the oxidase subunits and/or translocation from the cytosol to the plasma or granular membrane, but there is not the complete assembly required for O2- generation. Activation of PMNs is the complete assembly of the membrane-linked and cytosolic NADPH oxidase components on a PMN membrane, the plasma or granular membrane. This review will discuss the individual components associated with the NADPH oxidase complex and the function of each of these units in each physiologic stage of the PMN: rested, primed, and activated. 相似文献
9.
Paramagnetic macrocyclic chelates show promise as magnetic resonance (MR) imaging contrast agents due to stability and relaxivity comparable to those of DTPA-type chelates. For the three copper and manganese macrocyclic complexes studied in aqueous solution, T1 and T2 relaxivities ranged from 0.14 to 5.88 mM-1sec-1 at 6.25 MHz. In rats, the intravenous administration of 16 mumol/kg of Mn(cyclam) caused the liver T1 relaxation rate to double at 15 minutes after injection. T1 measurements by pulsed MR imaging and manganese analyses on excised tissue showed that both relaxation rate (1/T1) and manganese content of liver and kidney increase linearly with the dosage of Mn(cyclam). The linear relationship between 1/T1 and manganese content can be considered an "in tissue" relaxivity plot for the agent. The resulting relaxivity is 54 mM-1sec-1 in liver, compared with 3.1 mM-1sec-1 in aqueous solution. Although this work is preliminary, the implication for medical MR imaging applications is that macrocyclic contrast agents can be effective at approximately one-tenth the current typical dose used for gadolinium DTPA. 相似文献
10.
Developments over the past 2 decades concerning research on marriage preparation programs are reviewed. Suggestions for designing effective programs are presented. Issues reviewed include assessing client needs, the timing and duration of programs, formats and methods, program content, provider characteristics, and promotion and marketing strategies. 相似文献