全文获取类型
收费全文 | 1311篇 |
免费 | 108篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 35篇 |
妇产科学 | 57篇 |
基础医学 | 167篇 |
口腔科学 | 25篇 |
临床医学 | 133篇 |
内科学 | 334篇 |
皮肤病学 | 26篇 |
神经病学 | 99篇 |
特种医学 | 61篇 |
外科学 | 168篇 |
综合类 | 21篇 |
预防医学 | 49篇 |
眼科学 | 63篇 |
药学 | 74篇 |
中国医学 | 5篇 |
肿瘤学 | 94篇 |
出版年
2023年 | 13篇 |
2022年 | 5篇 |
2021年 | 49篇 |
2020年 | 36篇 |
2019年 | 44篇 |
2018年 | 42篇 |
2017年 | 36篇 |
2016年 | 33篇 |
2015年 | 35篇 |
2014年 | 58篇 |
2013年 | 62篇 |
2012年 | 102篇 |
2011年 | 118篇 |
2010年 | 64篇 |
2009年 | 45篇 |
2008年 | 82篇 |
2007年 | 77篇 |
2006年 | 66篇 |
2005年 | 67篇 |
2004年 | 52篇 |
2003年 | 58篇 |
2002年 | 51篇 |
2001年 | 33篇 |
2000年 | 25篇 |
1999年 | 26篇 |
1998年 | 10篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 13篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1982年 | 2篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
排序方式: 共有1426条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Outbreak of serogroup C meningococcal disease caused by a variant of Neisseria meningitidis serotype 2a ET-15 in a community of men who have sex with men 下载免费PDF全文
Tsang RS Kiefer L Law DK Stoltz J Shahin R Brown S Jamieson F 《Journal of clinical microbiology》2003,41(9):4411-4414
We describe an outbreak, in a community of men who have sex with men, of serogroup C meningococcal disease caused by a genetic variant of the serotype 2a ET-15 Neisseria meningitidis characterized by a point mutation in the gene coding for the serotype 2a antigen. A microbiological characterization of the outbreak strain is presented in this report. 相似文献
9.
Kim Han Komudi Singh Matthew J. Rodman Shahin Hassanzadeh Yvonne Baumer Rebecca D. Huffstutler Jinguo Chen Julin Candia Foo Cheung Katherine E. R. Stagliano Mehdi Pirooznia Tiffany M. Powell-Wiley Michael N. Sack 《Nutrients》2021,13(5)
Intermittent fasting and fasting mimetic diets ameliorate inflammation. Similarly, serum extracted from fasted healthy and asthmatic subjects’ blunt inflammation in vitro, implicating serum components in this immunomodulation. To identify the proteins orchestrating these effects, SOMAScan technology was employed to evaluate serum protein levels in healthy subjects following an overnight, 24-h fast and 3 h after refeeding. Partial least square discriminant analysis identified several serum proteins as potential candidates to confer feeding status immunomodulation. The characterization of recombinant IGFBP1 (elevated following 24 h of fasting) and PYY (elevated following refeeding) in primary human CD4+ T cells found that they blunted and induced immune activation, respectively. Furthermore, integrated univariate serum protein analysis compared to RNA-seq analysis from peripheral blood mononuclear cells identified the induction of IL1RL1 and MFGE8 levels in refeeding compared to the 24-h fasting in the same study. Subsequent quantitation of these candidate proteins in lean versus obese individuals identified an inverse regulation of serum levels in the fasted subjects compared to the obese subjects. In parallel, IL1RL1 and MFGE8 supplementation promoted increased CD4+ T responsiveness to T cell receptor activation. Together, these data show that caloric load-linked conditions evoke serological protein changes, which in turn confer biological effects on circulating CD4+ T cell immune responsiveness. 相似文献
10.
Sarah Wang Lina Patel Elise A. Sannar Mellad Khoshnood Natalie K. Boyd Lorena Mendez Noemi A. Spinazzi Eileen A. Quinn Michael S. Rafii Jonathan D. Santoro 《American journal of medical genetics. Part A》2023,191(7):1769-1782
Down syndrome regression disorder (DSRD) is a clinical symptom cluster of acute or subacute neurocognitive regression in otherwise health persons with Down syndrome. The objective of this study was to evaluate if adverse childhood experiences (ACEs) were more prevalent in children with DSRD than those with DS alone. A survey-based, cohort-based study was performed. Caregivers of individuals with DSRD with onset of symptoms between age 10 and 30 years and DS alone were administered the ACEs questionnaire via an online REDCap survey. A total of 159 responses were collected after excluding incomplete surveys and those not meeting criteria for DSRD. Individuals with DSRD were not more likely to experience ACEs (p = 0.18, 95% confidence interval [CI]: 0.43–1.17). In those with ACEs prior to the onset of symptoms, the median time prior was 7 months (interquartile range: 5–10). Individuals with DSRD were more likely to report three or more ACEs (52, 33%) compared to those with DS alone (39, 22%) (p = 0.02, 95% CI: 1.08–2.87). Exposure to ACEs were not predictive of response to particular therapeutic interventions although those with multiple ACEs 3 months prior to the onset of symptoms was associated with lower response rates to benzodiazepines and immunotherapy (p = 0.02, 95% CI: −3.64–−1.13). This study provides preliminary data that individuals with DSRD experience ACEs at a similar rate to individuals with only DS alone, although three or more ACEs, often preceding the onset of symptoms, was more prevalent in individuals with DSRD. 相似文献