全文获取类型
收费全文 | 1112篇 |
免费 | 78篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 115篇 |
妇产科学 | 11篇 |
基础医学 | 105篇 |
口腔科学 | 65篇 |
临床医学 | 173篇 |
内科学 | 252篇 |
皮肤病学 | 15篇 |
神经病学 | 19篇 |
特种医学 | 215篇 |
外科学 | 68篇 |
综合类 | 35篇 |
预防医学 | 43篇 |
眼科学 | 7篇 |
药学 | 32篇 |
1篇 | |
肿瘤学 | 44篇 |
出版年
2021年 | 3篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 12篇 |
2017年 | 11篇 |
2016年 | 8篇 |
2015年 | 20篇 |
2014年 | 19篇 |
2013年 | 19篇 |
2012年 | 22篇 |
2011年 | 20篇 |
2010年 | 40篇 |
2009年 | 45篇 |
2008年 | 26篇 |
2007年 | 11篇 |
2006年 | 15篇 |
2005年 | 19篇 |
2004年 | 14篇 |
2003年 | 17篇 |
2002年 | 22篇 |
2001年 | 17篇 |
2000年 | 12篇 |
1999年 | 21篇 |
1998年 | 86篇 |
1997年 | 85篇 |
1996年 | 97篇 |
1995年 | 59篇 |
1994年 | 55篇 |
1993年 | 47篇 |
1992年 | 23篇 |
1991年 | 25篇 |
1990年 | 17篇 |
1989年 | 41篇 |
1988年 | 35篇 |
1987年 | 41篇 |
1986年 | 21篇 |
1985年 | 32篇 |
1984年 | 23篇 |
1983年 | 19篇 |
1982年 | 16篇 |
1981年 | 17篇 |
1980年 | 9篇 |
1979年 | 4篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 9篇 |
1975年 | 8篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有1201条查询结果,搜索用时 250 毫秒
1.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
2.
The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, during and after DMBA treatment, groups of hamsters were also treated, on alternate days, with a 1% solution of DAS. In addition to tumor formation, the induction of gamma-glutamyl transpeptidase (gamma GT) buccal pouch epithelial lesions served as an additional presumptive index of in vivo carcinogenesis/anticarcinogenesis. DAS resulted in a significant reduction in buccal pouch tumor frequency, buccal pouch tumor burden, buccal pouch gamma GT lesion frequency and forestomach tumor frequency. In a separate experiment, DAS also reduced the level of autoradiographically quantified unscheduled DNA repair synthesis (UDS) in pieces of hamster buccal pouch concurrently exposed in vitro to the potent buccal pouch carcinogen N-methyl-N-benzylnitrosamine (MBN). This study demonstrates that DAS is an effective anticarcinogenic agent in squamous mucosa of the hamster and suggests novel cost-effective strategies for the rapid identification of tissue-specific anticarcinogens and a quantitative assessment of their efficacy. 相似文献
3.
P. J. Polverini 《The American journal of pathology》1996,148(4):1023-1029
4.
Hans Bosma Martin PJ van Boxtel Gertrudis IJM Kempen Jacques ThM van Eijk Jelle Jolles 《BMC public health》2007,7(1):179
Background
The aims of this study were to examine the extent to which higher intellectual abilities protect higher socio-economic groups from functional decline and to examine whether the contribution of intellectual abilities is independent of childhood deprivation and low birth weight and other socio-economic and developmental factors in early life. 相似文献5.
6.
7.
Previous reports in the literature have described correlation of increasing repeat length with severity of the phenotype, in Kennedy syndrome. We describe male siblings with different repeat lengths, with lack of expression of the phenotype in the sibling with the longer repeat length. The phenotype was identical to motor neurone disease. There is variability of expression in Kennedy syndrome and repeat length even in siblings cannot be taken as a conclusive indicator of severity. CAG repeat length cannot be used to predict the natural history of Kennedy disease. The diagnosis of Kennedy syndrome should be considered in male patients presenting with atypical motor neurone disease. 相似文献
8.
PJ Woll PhD MRCP R Pettengell PhD FRACP 《International journal of clinical practice》1997,51(2):111-115
SUMMARY The interferons are natural glycoproteins secreted in response to various stimuli, including viral infection. They have antiviral, antiproliferative and immunomodulatory effects on different target cell populations. Since recombinant human interferons have become available, they have been tested in a wide range of malignancies. They are well established in the treatment of hairy cell leukaemia, chronic myelogenous leukaemia and multiple myeloma. Although they have documented activity against lymphoma, melanoma, renal cell cancer and carcinoid tumours, their role in the treatment of these tumours is less clear. In the common solid tumours, such as lung cancer and colorectal cancer, the use of interferons remains experimental. Here we will summarise their practice applications in oncology, using randomised studies where available to establish their place in multi-modality treatment. We will not discuss their use as antiviral or immunomodulating agents in viral and autoimmune diseases, multiple sclerosis or after organ transplantation. 相似文献
9.
K. E. Foreman T. Wrone-Smith L. H. Boise C. B. Thompson P. J. Polverini P. L. Simonian G. Nunez B. J. Nickoloff 《The American journal of pathology》1996,149(3):795-803
Several recently identified proteins such as Bcl-2 and Bcl-x have been found to regulate programmed cell death (i.e., apoptosis). In this report, we examined the levels of expression of proteins that can either prevent apoptosis (i.e., Bcl-2 or the long form of Bcl-x, designated Bcl-x1) or promote apoptosis (i.e., Bax or the short form of Bcl-x, designated Bcl-xs) in proliferating benign and malignant endothelial cells (ECs). In normal skin with quiescent ECs, no detection by immunohistochemical staining was observed for Bcl-xL, Bcl-xs, or Bcl-2. However, in diseased skin samples that feature a prominent angiogenic response such as in psoriasis or pyogenic granulomas, the proliferating ECs markedly overexpressed Bcl-xL, with little to no Bcl-2. In an acquired-immune-deficiency-syndrome-related neoplasm, Kaposi's sarcoma, the spindle-shaped tumor cells also overexpressed Bcl-xL compared with Bcl-2. These in vivo studies were extended in vitro using cultured ECs and Kaposi's sarcoma tumor cells that were examined by flow cytometry and immunoblot analysis. Both cultured ECs and Kaposi's sarcoma tumor cells express significantly higher levels of Bcl-xL than Bcl-2. Such overexpression of cell survival gene products may contribute to prolonging the longevity of EC-derived cells in several different benign and neoplastic skin disorders that are characterized by a prominent angiogenic tissue response. 相似文献
10.