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排序方式: 共有47条查询结果,搜索用时 828 毫秒
1.
Chaijaroonkhanarak Wunnee Amarttayakong Pattama Ratanasuwan Somsiri Kirirat Pornpimol Pannangrong Wanassanan Welbat Jariya Umka Prachaney Parichat Chaichun Amnart Sae-Jung Surachai 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2019,29(3):559-565
European Journal of Orthopaedic Surgery & Traumatology - Variations of morphology of the glenoid cavity have been previously reported. These influence the surgical reconstruction or... 相似文献
2.
Koichiro Higasa Jun-Ichi Manabe Toshitsuga Yubisui Hideki Sumimoto Parichat Pung-amritt Varavarn S. Tanphaichitr & Yasuyuki Fukumaki 《British journal of haematology》1998,103(4):922-930
Hereditary methaemoglobinaemia, caused by deficiency of NADH-cytochrome b5 reductase (b5R), has been classified into two types, an erythrocyte (type I) and a generalized (type II). We analysed the b5R gene of two Thai patients and found two novel mutations. The patient with type II was homozygous for a C-to-T substitution in codon 83 that changes Arg (CGA) to a stop codon (TGA), resulting in a truncated b5R without the catalytic portion. The patient with type I was homozygous for a C-to-T substitution in codon 178 causing replacement of Ala (GCG) with Val (GTG). To characterize effects of this missense mutation, we investigated enzymatic properties of mutant b5R (Ala 178 Val). Although the mutant enzyme showed normal catalytic activity, less stability and different spectra were observed. These results suggest that this substitution influenced enzyme stability due to the slight change of structure. In conclusion, the nonsense mutation led to type II because of malfunction of the truncated protein. On the other hand, the missense mutation caused type I, due to degradation of the unstable mutant enzyme with normal activities in patient's erythrocytes, because of the lack of compensation by new protein synthesis during the long life-span of erythrocytes. 相似文献
3.
Kihara Y Satho T Eshita Y Sakai K Kotaki A Takasaki T Rongsriyam Y Komalamisra N Srisawat R Lapcharoen P Sumroiphon S Iwanaga S Ushijima H Endoh D Miyata T Sakata A Kashige N Miake F Fukushi S Saijo M Kurane I Morikawa S Mizutani T 《Journal of virological methods》2007,146(1-2):372-374
A method for rapid determination of viral RNA sequences (RDV) was applied to homogenates of Aedes aegypti collected in Thailand in an area in which dengue fever (dengue hemorrhagic fever) is endemic, using the mosquito cell line C6/36. Nucleic acid sequences of dengue virus type 4 and cell fusing agent virus were detected. This RDV method has the potential to become a standard method for detection of both known and newly emerging, unknown mosquito-borne viruses. 相似文献
4.
Vip Viprakasit Worrawut Chinchang Parichat Pung-Amritt Voravarn S. Tanphaichitr 《Hematology (Amsterdam, Netherlands)》2013,18(2):151-155
More than 30 different hemoglobin variants either affecting or β globin chains have been identified in Thailand. The large variety in the different forms of hemoglobinopathy contributes to several complicated interactions, since different types of defective globin alleles are prevalent in Thailand and nearly 30-40% of the population are carriers of either or β thalassemia (thal). Many rare and novel abnormal globin variants in Thai subjects have been identified in our laboratory within the past few years; including Hb Lepore-Hollandia, homozygous Hb Tak, Hb Dhonburi, Hb G-Makassar, Hb G-Coushatta, Hb New York, Hb Paksè and Hb Pak Num Po. In addition to these, here we report, for the first time, the identification of Hb Q-India, an innocuous globin variant, in a Thai family with Indian ancestry. This report highlights the complexity associated with identifying unknown globin variants within a population that has a heterogeneous repertoire of globin chain disorders. 相似文献
5.
Akkarapatumwong V Intorasoot S Oranwiroon S Thano-Otarakul P Pung-Amritt P Veerakul G Mahasandana C Panyim S Yenchitsomanus P 《Human mutation》2000,16(6):530-531
Six frameshift mutations in exon 14 of the factor VIII gene were identified in Thai hemophilia A patients. Although all these mutations created premature stop codons and expected to cause severe disease, the molecular defects and clinical severity were in discrepancy in some patients. Four mutations (delT3490, delACAC3618-21, delGA4429-30, and delA4658) were found in the patients with the severe clinical phenotype while two (delA3629-37 and insA4372-9) were observed in the patients who had moderate severity, with FVIII:C of 4.2 and 2.8%. The frameshift mutations in these two patients were due to deletion and insertion of an 'A' nucleotide in the stretches of 9As and 8As in codons 1191-4 and 1439-41, respectively. This indicates that deletion or insertion in the stretches of poly A nucleotides in exon 14 of the factor VIII gene is a likely cause of the moderate clinical severity in some cases of Thai hemophilia A patients. 相似文献
6.
Despite a significant commitment to tackling childhood overweight and obesity, questions remain about the progress the Thai Government has made in implementing childhood obesity prevention policies and actions. This study aimed to review and assess the implementation of the government’s policies and actions for childhood obesity prevention in Thailand compared with the recommendations of the Commission on Ending Childhood Obesity and to identify the implementation gaps. Policy data were collected from governmental and NGO websites and publications and via direct contact with government officials. Stakeholder meetings were held to seek further information and advice on implementation gaps and to give recommendations. The analysis of each policy was conducted against pre-determined criteria formulated from literature assessments and stakeholder consultations. The policies and actions that were implemented by the Government were consistent with 33 broad policy actions and 55 specific policy actions. Preconception and pregnancy care was the policy area that was most implemented. Six broad policy actions were assessed as ‘high’ performance, these were: sugar-sweetened beverage taxation, nutrient labeling, nutrition guidance for preconception and pregnancy care, the International Code of Marketing of Breast-milk Substitutes, regulatory measures for supporting maternal breastfeeding, and regulations on the marketing of complementary foods and beverages. Policy coherence and monitoring and evaluation (M&E) were identified as major implementation gaps. Increasing the effectiveness of childhood obesity prevention in Thailand will require national immediate attention towards building infrastructure to enhance coherence among the policies and to put in place M&E mechanisms for each policy. 相似文献
7.
8.
Viprakasit V Chinchang W Pung-Amritt P Tanphaichitr VS 《Hematology (Amsterdam, Netherlands)》2004,9(2):151-155
More than 30 different hemoglobin variants either affecting alpha or beta globin chains have been identified in Thailand. The large variety in the different forms of hemoglobinopathy contributes to several complicated interactions, since different types of defective globin alleles are prevalent in Thailand and nearly 30-40% of the population are carriers of either alpha or beta thalassemia (thal). Many rare and novel abnormal globin variants in Thai subjects have been identified in our laboratory within the past few years; including Hb Lepore-Hollandia, homozygous Hb Tak, Hb Dhonburi, Hb G-Makassar, Hb G-Coushatta, Hb New York, Hb Paksè and Hb Pak Num Po. In addition to these, here we report, for the first time, the identification of Hb Q-India, an innocuous alpha globin variant, in a Thai family with Indian ancestry. This report highlights the complexity associated with identifying unknown globin variants within a population that has a heterogeneous repertoire of globin chain disorders. 相似文献
9.
Ketmanee Senaphan Upa Kukongviriyapan Weerapon Sangartit Poungrat Pakdeechote Patchareewan Pannangpetch Parichat Prachaney Stephen E. Greenwald Veerapol Kukongviriyapan 《Nutrients》2015,7(8):6446-6464
Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin resistance, vascular dysfunction and remodeling in a rat model of high-carbohydrate, high-fat diet-induced metabolic changes, which is regarded as an analogue of metabolic syndrome (MS) in man. Male Sprague-Dawley rats were fed a high carbohydrate, high fat (HCHF) diet and 15% fructose in drinking water for 16 weeks, where control rats were fed with standard chow diet and tap water. FA (30 or 60 mg/kg) was orally administered to the HCHF and control rats during the last six weeks of the study. We observed that FA significantly improved insulin sensitivity and lipid profiles, and reduced elevated blood pressure, compared to untreated controls (p < 0.05). Moreover, FA also improved vascular function and prevented vascular remodeling of mesenteric arteries. The effects of FA in HCHF-induced MS may be realized through suppression of oxidative stress by down-regulation of p47phox, increased nitric oxide (NO) bioavailability with up-regulation of endothelial nitric oxide synthase (eNOS) and suppression of tumor necrosis factor-α (TNF-α). Our results suggest that supplementation of FA may have health benefits by minimizing the cardiovascular complications of MS and alleviating its symptoms. 相似文献
10.
Evidence‐based recommendations for the diagnosis and management of rheumatoid arthritis for non‐rheumatologists: Integrating systematic literature research and expert opinion of the Thai Rheumatism Association 下载免费PDF全文
Wanruchada Katchamart Pongthorn Narongroeknawin Parawee Chevaisrakul Pornchai Dechanuwong Ajanee Mahakkanukrauh Nuntana Kasitanon Rattapol Pakchotanon Kittiwan Sumethkul Parichat Ueareewongsa Sittichai Ukritchon Thitirat Bhurihirun Kittikorn Duangkum Porntip Intapiboon Samanan Intongkam Wimol Jangsombatsiri Kanon Jatuworapruk Naravadee Kositpesat Pawinee Leungroongroj Wiyanoot Lomarat Chonachan Petcharat Siriluck Sittivutworapant Patcharawan Suebmee Pongchirat Tantayakom Worakan Tipsing Paijit Asavatanabodee Praveena Chiowchanwisawakit Chingching Foocharoen Ajchara Koolvisoot Worawit Louthrenoo Boonjing Siripaitoon Kitti Totemchokchyakarn Tasanee Kitumnuaypong the Thai Rheumatism Association 《International journal of rheumatic diseases》2017,20(9):1142-1165