Respiratory muscle dysfunction in facioscapulohumeral muscular dystrophy

Sleep and Breathing -     

Vital Capacity Versus Maximal Inspiratory Pressure in Patients with Guillain–Barré Syndrome and Myasthenia Gravis

Background

The objective is to determine whether maximal inspiratory pressure (P _imax) measurement is more sensitive than vital capacity (VC) measurement to detect acute respiratory muscle failure considering a theoretical curvilinear relationship between volume and pressure.

Methods

Review of VC and P _imax of all patients hospitalized in ICU for Guillain?CBarré syndrome (GBS) and myasthenia gravis (MG) exacerbation.

Results

84 consecutive caucasian patients between 19- and 70-years-old hospitalized in intensive care unit from April 2008 to December 2010, for MG exacerbation (44 patients) and GBS (40 patients). The regression curve between VC and P _imax was linear rather than exponential (r?=?0.599, P?>?0.0001). The contingency table demonstrated agreement between VC and P _imax (??^2?=?26.7, P?=?0.0001), with similar number of patients having abnormal P _imax associated to normal VC and normal P _imax associated to abnormal VC (9 (10.7%) vs. 8 (9.5%) respectively). Six of the patients developed an important decrease of VC from normal value to less than 60% of the predicted value and did not present evident curvilinear relationship between VC and P _imax during this follow-up.

Conclusions

Because the regression between VC and P _imax was linear rather than curvilinear, P _imax was not more sensitive than VC for early detection of respiratory muscle failure in patients hospitalized in ICU for GBS and MG exacerbation. Therefore, VC remains well suited to assess acute respiratory muscle failure and P _imax gives poor additional information.