全文获取类型
收费全文 | 7890篇 |
免费 | 595篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 262篇 |
妇产科学 | 187篇 |
基础医学 | 1113篇 |
口腔科学 | 115篇 |
临床医学 | 800篇 |
内科学 | 1507篇 |
皮肤病学 | 246篇 |
神经病学 | 690篇 |
特种医学 | 242篇 |
外科学 | 734篇 |
综合类 | 151篇 |
一般理论 | 4篇 |
预防医学 | 762篇 |
眼科学 | 180篇 |
药学 | 706篇 |
1篇 | |
中国医学 | 71篇 |
肿瘤学 | 752篇 |
出版年
2023年 | 52篇 |
2022年 | 42篇 |
2021年 | 227篇 |
2020年 | 130篇 |
2019年 | 203篇 |
2018年 | 234篇 |
2017年 | 206篇 |
2016年 | 217篇 |
2015年 | 241篇 |
2014年 | 352篇 |
2013年 | 397篇 |
2012年 | 612篇 |
2011年 | 583篇 |
2010年 | 354篇 |
2009年 | 303篇 |
2008年 | 496篇 |
2007年 | 483篇 |
2006年 | 442篇 |
2005年 | 466篇 |
2004年 | 467篇 |
2003年 | 385篇 |
2002年 | 339篇 |
2001年 | 135篇 |
2000年 | 86篇 |
1999年 | 93篇 |
1998年 | 102篇 |
1997年 | 77篇 |
1996年 | 43篇 |
1995年 | 44篇 |
1994年 | 61篇 |
1993年 | 49篇 |
1992年 | 53篇 |
1991年 | 40篇 |
1990年 | 31篇 |
1989年 | 30篇 |
1988年 | 49篇 |
1987年 | 36篇 |
1986年 | 29篇 |
1985年 | 23篇 |
1984年 | 22篇 |
1983年 | 20篇 |
1982年 | 21篇 |
1980年 | 22篇 |
1977年 | 19篇 |
1976年 | 18篇 |
1975年 | 14篇 |
1973年 | 15篇 |
1972年 | 24篇 |
1970年 | 19篇 |
1968年 | 14篇 |
排序方式: 共有8566条查询结果,搜索用时 15 毫秒
1.
2.
3.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
4.
5.
6.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
7.
Frank Lindseth Thomas Lang? Jon Bang Toril A Nagelhus Hernes 《Computer aided surgery》2002,7(4):197-222
8.
Leonard A. Jason PhD Steven B. Pokorny PhD Monica Adams MPH Annie Topliff MA Courtney Harris BA Yvonne Hunt PhD 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》2009,18(5):367-374
This study evaluated the effects of tobacco Purchase, Use and Possession (PUP) laws on student perceptions of adolescent tobacco use within towns and schools. Twenty‐four towns were randomly assigned into two conditions, the experimental condition (E PUP) involved efforts to increase both PUP law enforcement and reduce minors' access to commercial sources of tobacco, whereas the control condition (C) focused only on efforts to reduce minors' access to commercial sources of tobacco. A hierarchical linear modeling analytical approach was selected due to the multilevel data and nested design. The present study found that over time, youth in the experimental PUP condition observed less youth tobacco usage at school and in their town, and perceived lower rates of tobacco among their peers at school and among friends than youth in the control condition. The findings suggest that PUP law enforcement might be used to strengthen community norms against youth tobacco use. 相似文献
9.
10.