罕见的输血相关急性肺损伤导致患者死亡1例

患者女,70岁。因反复发热、尿频、头昏、乏力,于2002年9月5日入院。检查血红蛋白41 g/L,血小板83×10~9/L,白细胞2.4×10~9/L,尿本周蛋白+,IgG 30 g/L。骨髓检查(骨髓瘤细胞54％)确诊为多发性骨髓瘤。给予输血等对症治疗,行MP方案化疗1次,因全身较差及经济条件有限,决定放弃进一步治疗,给予间断输血维持生命。2002年10月5～7日共输红细胞浓悬液8个单位,2002年11月15～28日共输红细胞浓悬液8个单位,2003     

《针灸学》移动交互式数字教村在针灸学教学中的应用与研究

随着互联网技术的发展及移动设备的广泛应用,高等教育的教学模式和教学理念发生了巨大的变化,学生的学习方式亦随之改变.除传统教学模式外,高等院校针灸学的课堂教学应当充分挖掘移动设备的教学功能,以便于更好地开展课堂教学活动,提高教学效果.     

Therapeutic observation on electroacupuncture at Zusanli (ST 36) and Fenglong (ST 40) for senile dementia

Objective

To explore the clinical effects of electroacupuncture (EA) at Zusanli (ST 36) and Fenglong (ST 40) in treating senile dementia.

Methods

A total of 74 patients were randomly divided into an EA group and a medication group based upon the random digital table, 37 cases in each group. EA at Zusanli (ST 36) and Fenglong (ST 40) was given in the EA group, once every day, for six treatments per week. Donepezil Hydrochloride Tablets were given to the medication group, 5 mg per time and once a day in the former four weeks, 10 mg per time and once a day after 4 weeks, oral administration before sleep at night. The courses of the treatment were 12 weeks in both groups. The scores of mini-mental state examination (MMSE) and Barthel index (BI) were observed before and after the treatment, for processing the comparative analysis of the clinical effects after the course of the treatment.

Results

The total effective rate was 86.5% in the EA group and 70.3% in the medication group. The therapeutic effect was better in the EA group than that in the medication group, and the difference between the two groups was statistically significant (P<0.05). MMSE and BI scores after the treatment in the two groups were all elevated than those of the same groups before the treatment (P<0.05, P<0.01). The improving situation was obviously better in the EA group than that in the medication group, and the difference between the two groups was statistically significant (P<0.05).

Conclusion

EA at Zusanli (ST 36) and Fenglong (ST 40) is affirmative in the therapeutic effect for senile dementia and can also improve the cognitive function and enhance the patients’ quality of life.

     

青黛治疗慢性粒细胞型白血病远期疗效观察

1974年9月至1977年1月,我们用青黛治疗慢性粒细胞型白血病(以下简称慢粒)17例,其中获得完全缓解者3例,部分缓解者6     

N′-乙酰靛玉红治疗慢性粒细胞白血病临床研究

我们从多种靛玉红衍生物中筛选出治疗慢粒有效药物N′-乙酰靛玉红。用N′-乙酰靛玉红治疗慢粒27例,完全缓解12例(44.44％),部份缓解14例(51.85％),进步1例(3.71％),缓解率96.29％,有效率100％,治疗9.52±6.20天后脾脏开始缩小,19.62±12.22天外周血白细胞数开始下降;达到最佳疗效(缓解)平均为87.62天,最短28天,最长206天;有5例出现腹胀、腹痛、大便次数增多,食欲不振等反应,但都能坚持用药,本组病例已发生急变者9例(33.3％)。临床研究结果表明,N′-乙酰靛玉红对慢粒具有良好疗效,不良反应轻微,优于靛玉红,值得进一步研究。     

青黛治疗慢性粒细胞性白血病的疗效观察

我们与兄弟单位协作,在中药当归芦荟丸治疗慢性粒细胞性白血病(以下简称慢粒)有效的基础上,从中筛选到有效中药青黛。1974年9月至1977年1月期间,我院用青黛治疗慢粒病人17例,至1978年8月时,17例中已死亡者5例,其余12例在最近一次随访时仍存活。17例的平均生存时间已有38.7个月,中数生存期将超过35个月。现简单介绍青黛治疗慢粒17例的情况于下。治疗药物一、青黛是常用中药,味成性寒,入肝经,功能泻肝经实火,散郁火,清热解毒,凉血止血,消斑,治疮疡。青黛是用大青叶作原料在制靛过程中所得到的副产品。大青叶的品种甚复杂,常用者有     

试论微课在腧穴教学中的应用与实践

探讨微课在针灸推拿专业腧穴教学中的应用和实践,选取针灸推拿专业入门学科经络腧穴学中核心部分-腧穴部分,利用PPT转换成视频的方式,制作成微课。根据腧穴部分的知识点,结合微课平台,探索在互联网时代如何充分利用碎片化的闲余时间,将传统课堂与网络教学结合起来,提高针灸学的教学效果。     

Effect of herbal cake-partitioned moxibustion on MEK1/2 and ERK1/2 expressions of gastric tissues in rats with spleen deficiency syndrome

Objective

To observe the effect of herbal cake-partitioned moxibustion on the expressions of mitogen-activated protein kinase (MEK1/2) and extracellular regulatory protein kinase (ERK1/2) in gastric tissues of rats with spleen deficiency syndrome, and to explore the possible mechanisms of herbal cake-partitioned moxibustion in treating spleen deficiency syndrome.

Methods

Sixty Sprague-Dawley (SD) rats were randomly divided into a blank control group (group A), a model group (group B), a ranitidine group (group C), and a herbal cake-partitioned moxibustion group (group D) by random digit, 15 rats in each group. Rat models of spleen deficiency syndrome were made by intragastric administration of 4 °C 200% concentrated Da Huang (Radix et Rhizoma Rhei). After successful modeling, the rats in group C were treated with 25 mg/(kg·bw) ranitidine by intragastric adminstration and rats in group D were treated with herbal cake-partitioned moxibustion at Zusanli (ST 36) and Zhongwan (CV 12), for 8 d. Excepted for rats in group A, all the other rats were treated with indomethacin at 5 mg/(kg·bw) at 8:00 a.m. on the second day after finishing all the intervention and sacrificed 7 h later to isolate the stomach. Histopathological changes of the gastric tissues were observed under light microscope after hematoxylin-eosin (HE) staining. The protein expressions of MEK1/2 and ERK1/2 in the gastric tissues were detected by immunohistochemistry.

Results

After intervention, the gastric mucosal injury in group B was significantly severer than that in group A, with large breakage and ablating; the damage of gastric mucosa was decreased in group C compared with group B; the gastric mucosal surface remained relatively complete, and the status of breakage and ablating was significantly improved. After intervention, compared with group A, the protein expressions of MEK1/2 and ERK1/2 in gastric tissues of the other groups were significantly higher (P<0.01). Compared with group B, the protein expressions of MEK1/2 and ERK1/2 in group C and D were significantly higher (all P<0.01). Compared with group C, the protein expressions of MEK1/2 and ERK1/2 in group D were significantly higher (P<0.01).

Conclusion

Herbal cake-partitioned moxibustion promotes the repair of gastric mucosa in rats with spleen deficiency syndrome, via improving protein expressions of MEK1/2 and ERK1/2 in gastric tissues, as well as activating MEK/ERK signaling pathway.

     

信息技术在医院党建工作中的创新应用

随着信息技术的快速发展,信息技术已成为人们生产和生活的重要组成部分,同时也对医院党建管理方式的变化产生了巨大的影响,笔者在长期的医院党建实践中,探索利用现代信息技术优势,创新医院党建工作方式,取得党建工作的最大效能.