全文获取类型
收费全文 | 43317篇 |
免费 | 3340篇 |
国内免费 | 124篇 |
专业分类
耳鼻咽喉 | 391篇 |
儿科学 | 1208篇 |
妇产科学 | 773篇 |
基础医学 | 6260篇 |
口腔科学 | 698篇 |
临床医学 | 4724篇 |
内科学 | 8934篇 |
皮肤病学 | 846篇 |
神经病学 | 4480篇 |
特种医学 | 1587篇 |
外国民族医学 | 11篇 |
外科学 | 5739篇 |
综合类 | 494篇 |
一般理论 | 42篇 |
预防医学 | 3832篇 |
眼科学 | 911篇 |
药学 | 3227篇 |
中国医学 | 99篇 |
肿瘤学 | 2525篇 |
出版年
2023年 | 362篇 |
2022年 | 215篇 |
2021年 | 1146篇 |
2020年 | 796篇 |
2019年 | 1092篇 |
2018年 | 1234篇 |
2017年 | 986篇 |
2016年 | 1124篇 |
2015年 | 1187篇 |
2014年 | 1584篇 |
2013年 | 2028篇 |
2012年 | 3157篇 |
2011年 | 3267篇 |
2010年 | 1846篇 |
2009年 | 1541篇 |
2008年 | 2509篇 |
2007年 | 2687篇 |
2006年 | 2585篇 |
2005年 | 2351篇 |
2004年 | 2193篇 |
2003年 | 1892篇 |
2002年 | 1759篇 |
2001年 | 692篇 |
2000年 | 695篇 |
1999年 | 635篇 |
1998年 | 384篇 |
1997年 | 293篇 |
1996年 | 282篇 |
1995年 | 259篇 |
1994年 | 212篇 |
1993年 | 177篇 |
1992年 | 337篇 |
1991年 | 319篇 |
1990年 | 321篇 |
1989年 | 255篇 |
1988年 | 256篇 |
1987年 | 284篇 |
1986年 | 297篇 |
1985年 | 285篇 |
1984年 | 235篇 |
1983年 | 186篇 |
1982年 | 131篇 |
1981年 | 133篇 |
1980年 | 130篇 |
1979年 | 248篇 |
1978年 | 165篇 |
1977年 | 142篇 |
1976年 | 130篇 |
1974年 | 135篇 |
1973年 | 142篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
1.
Streibert Fridolin Bernhardt Claudia Simon Philipp Hilbert-Carius Peter Wrigge Hermann 《Der Anaesthesist》2023,72(1):57-62
Die Anaesthesiologie - Die Anlage einer Magensonde im OP oder auf einer Intensivstation (ITS) stellt eine alltäglich durchgeführte Prozedur dar. Obwohl die Sonde häufig durch... 相似文献
2.
3.
Gokhlesh Kumar Subhodeep Sarker Simon Menanteau-Ledouble Mansour El-Matbouli 《Parasitology research》2015,114(6):2301-2308
4.
5.
6.
7.
Clare Delany PhD Master MSPT BAppSc Ian Edwards PhD Grad Dip PT BAppSc Caroline Fryer PhD Grad Dip BAppSc 《Physiotherapy theory and practice》2019,35(7):663-676
The profile and reach of physiotherapy has expanded in areas of extended scope of practice, and broader engagement with population needs beyond the individual treatment encounter. These changes raise increasingly complex ethical challenges evidenced by growth in physiotherapy-based ethics studies and discussions. This paper examines how a broad cross section of Australian physiotherapists perceive, interpret, and respond to ethical challenges in their work contexts and how professional codes of conduct are used in their practice. Using an interpretive qualitative methodology, purposive sampling of 88 members of national clinical special interest groups were recruited for focus group discussions. Narrative-based and thematic data analysis identified ethical challenges as emerging from specific clinical contexts, and influenced by health organizations, funding policies, workplace relationships, and individually held perspectives. Five themes were developed to represent these findings: (1) the working environment, (2) balancing diverse needs and expectation, (3) defining ethics, (4) striving to act ethically, and (5) talking about ethics. The results portray a diverse and complex ethical landscape where therapists encounter and grapple with ethical questions emerging from the impact of funding models and policies affecting clinical work, expanding boundaries and scope of practice and changing professional roles and relationships. Codes of conduct were described as foundational ethical knowledge but not always helpful for “in the moment” ethical decision-making. Based on this research, we suggest how codes of conduct, educators, and professional associations could cultivate and nurture ethics capability in physiotherapy practitioners for these contemporary challenges. 相似文献
8.
The Venom of Philippine Tarantula (Theraphosidae) Contains Peptides with Pro-Oxidative and Nitrosative-Dependent Cytotoxic Activities against Breast Cancer Cells (MCF-7) In Vitro 下载免费PDF全文
Simon Miguel M LopezJeremey S AguilarJerene Bashia B FernandezAngelic Gayle J LaoMitzi Rain R EstrellaMark Kevin P Devanadera Anna Beatriz R Mayor Leonardo A Guevarra Jr Myla R Santiago-Bautista Olga M NunezaLibrado Santiago 《Asian Pacific journal of cancer prevention》2020,21(8):2423-2430
Background: Breast cancer is a multifactorial disease that affects women worldwide. Its progression is likely to be executed by oxidative stress wherein elevated levels of reactive oxygen and nitrogen species drive several breast cancer pathologies. Spider venom contains various pharmacological peptides which exhibit selective activity to abnormal expression of ion channels on cancer cell surface which can confer potent anti-cancer activities against this disease. Methods: Venom was extracted from a Philippine tarantula by electrostimulation and fractionated by reverse phase-high performance liquid chromatography (RP-HPLC). Venom fractions were collected and used for in vitro analyses such as cellular toxicity, morphological assessment, and oxidative stress levels. Results: The fractionation of crude spider venom generated several peaks which were predominantly detected spectrophotometrically and colorimetrically as peptides. Treatment of MCF-7 cell line of selected spider venom peptides induced production of several endogenous radicals such as hydroxyl radicals (•OH), nitric oxide radicals (•NO), superoxide anion radicals (•O2−) and lipid peroxides via malondialdehyde (MDA) reaction, which is comparable with the scavenging effects afforded by 400 µg/mL vitamin E and L-cysteine (p<0.05). Concomitantly, the free radicals produced decrease the mitochondrial membrane potential and metabolic activity as detected by rhodamine 123 and tetrazolium dye respectively (p>0.05). This is manifested by cytotoxicity in MCF-7 cells as seen by increase in membrane blebbing, cellular detachment, caspase activity and nuclear fragmentation. Conclusion: These data suggest that the Philippine tarantula venom contains peptide constituents exhibiting pro-oxidative and nitrosative-dependent cytotoxic activities against MCF-7 cells and can indicate mechanistic insights to further explore its potential application as prooxidants in cancer therapy. 相似文献
9.
Turnbull Chris D. Stockley James A. Madathil Shyam Huq Syed S. A. Cooper Brendan G. Ali Asad Wharton Simon Stradling John R. Heitmar Rebekka 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(7):2129-2139
Graefe's Archive for Clinical and Experimental Ophthalmology - Retinal microvascular endothelial dysfunction is thought to be of importance in the development of ocular vascular diseases.... 相似文献