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The Role of International Traveling Fellowships in Training the Contemporary US Hand Surgeon

Jacques Hacquebord Aaron Berger Neil Jones 《The Journal of hand surgery》2021,46(2):142-145

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Correction: Thrombotic and bleeding events,mortality, and anticoagulant use among 546,656 hospitalized patients with COVID‑19 in the United States: a retrospective cohort study

Deitelzweig Steve Luo Xuemei Nguyen Jennifer L. Malhotra Deepa Emir Birol Russ Cristina Li Xiaoyan Lee Theodore C. Ferri Mauricio Wiederkehr Danny Reimbaeva Maya Barnes Geoffrey D. Piazza Gregory 《Journal of thrombosis and thrombolysis》2022,54(4):696-696

Journal of Thrombosis and Thrombolysis - 相似文献

Hypofractionated radiation therapy for durable palliative treatment of bleeding,fungating breast cancers

Amardeep S. Grewal Gary M. Freedman Joshua A. Jones Neil K. Taunk 《Practical radiation oncology》2019,9(2):73-76

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Neuromuscular ultrasound training courses in the post COVID-19 era: Is virtual training here to stay,and should the pre-pandemic training design be revised?

Luciana Pelosi Neil G. Simon 《Muscle & nerve》2022,65(1):1-3

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Microplegia in cardiac surgery: Systematic review and meta-analysis

Claire M. Owen BSc Sanjay Asopa MD FRCS Neil A. Smart PhD Nicola King PhD 《Journal of cardiac surgery》2020,35(10):2737-2746

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Welcome to the 16th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion

Karthik Thangappan Allison Barnes Angela Lorts David L. S. Morales Akif Ündar 《Artificial organs》2020,44(4):355-360

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Winners in the 2015 Naylor prize competition

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Neil Charman 《Ophthalmic & physiological optics》2016,36(6):682-683

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Impact of the Patient Protection and Affordable Care Act on cost-related medication underuse in nonelderly adult cancer survivors

Justin M. Barnes MS Kimberly J. Johnson PhD MPH Eric Adjei Boakye PhD Rosh K. V. Sethi MD MPH Mark A. Varvares MD Nosayaba Osazuwa-Peters PhD BDS MPH CHES 《Cancer》2020,126(12):2892-2899

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Clinical implications of drug-induced liver injury in early-phase oncology clinical trials

Sebastian P. Mondaca MD Dazhi Liu PharmD BCOP Jessica R. Flynn Sandy Badson Stefan Hamaway BS Mrinal M. Gounder MD Danny N. Khalil MD PhD Alexander E. Drilon MD Bob T. Li MD MPH Komal L. Jhaveri MD Alison M. Schram MD Katherine E. Kargus RN Mary Kate Kasler DNP MSN Natalie M. Blauvelt Neil H. Segal MD PhD Marinela Capanu PhD Margaret K. Callahan MD PhD David M. Hyman MD Maya Gambarin-Gelwan MD James J. Harding MD 《Cancer》2020,126(22):4967-4974

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10.

FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer

Sebastian Mondaca Walid K. Chatila David Bates Jaclyn F. Hechtman Andrea Cercek Neil H. Segal Zsofia K. Stadler Anna M. Varghese Ritika Kundra Marinela Capanu Jinru Shia Nikolaus Schultz Leonard Saltz Rona Yaeger 《Clinical colorectal cancer》2019,18(1):e39-e52

Background

Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and efficacy of a modified schedule, FOLFCIS (leucovorin, fluorouracil, and cisplatin), and performed an integrated clinical and genomic analysis of anal SCC.

Patients and Methods

We reviewed all patients with advanced anal SCC receiving first-line FOLFCIS chemotherapy – essentially a FOLFOX (leucovorin, fluorouracil, and oxaliplatin) schedule with cisplatin substituted for oxaliplatin – in our institution between 2007 and 2017, and performed deep sequencing to identify genomic markers of response and key genomic drivers.

Results

Fifty-three patients with advanced anal SCC (48 metastatic; 5 unresectable, locally advanced) received first-line FOLFCIS during this period; all were platinum-naive. The response rate was 48% (95% confidence interval [CI], 32.6%-63%). With a median follow-up of 41.6 months, progression-free survival and overall survival were 7.1 months (95% CI, 4.4-8.6 months) and 22.1 months (95% CI, 16.9-28.1 months), respectively. Among all patients with advanced anal SCC that underwent sequencing during the study period, the most frequent genomic alterations consisted of chromosome 3q amplification (51%) and mutations in PIK3CA (29%) and KMT2D (22%). No genomic alteration correlated with response to platinum-containing treatment. Although there were few cases, patients with human papillomavirus-negative anal SCC did not appear to benefit from FOLFCIS, and all harbored distinct genomic profiles with TP53, TERT promoter, and CDKN2A mutations.

Conclusions

FOLFCIS appears effective and safe as first-line chemotherapy in patients with advanced anal SCC and represents an alternative treatment option for these patients. 相似文献

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