全文获取类型
收费全文 | 1380篇 |
免费 | 118篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 104篇 |
妇产科学 | 42篇 |
基础医学 | 162篇 |
口腔科学 | 12篇 |
临床医学 | 165篇 |
内科学 | 315篇 |
皮肤病学 | 24篇 |
神经病学 | 87篇 |
特种医学 | 93篇 |
外国民族医学 | 3篇 |
外科学 | 170篇 |
综合类 | 19篇 |
预防医学 | 106篇 |
眼科学 | 11篇 |
药学 | 105篇 |
中国医学 | 3篇 |
肿瘤学 | 64篇 |
出版年
2021年 | 28篇 |
2020年 | 20篇 |
2019年 | 34篇 |
2018年 | 25篇 |
2017年 | 34篇 |
2016年 | 30篇 |
2015年 | 26篇 |
2014年 | 34篇 |
2013年 | 32篇 |
2012年 | 53篇 |
2011年 | 49篇 |
2010年 | 38篇 |
2009年 | 51篇 |
2008年 | 67篇 |
2007年 | 72篇 |
2006年 | 54篇 |
2005年 | 63篇 |
2004年 | 48篇 |
2003年 | 51篇 |
2002年 | 42篇 |
2001年 | 58篇 |
2000年 | 49篇 |
1999年 | 48篇 |
1998年 | 32篇 |
1997年 | 23篇 |
1996年 | 22篇 |
1995年 | 14篇 |
1994年 | 17篇 |
1993年 | 18篇 |
1992年 | 27篇 |
1991年 | 16篇 |
1990年 | 32篇 |
1989年 | 27篇 |
1988年 | 30篇 |
1987年 | 24篇 |
1986年 | 19篇 |
1985年 | 29篇 |
1984年 | 7篇 |
1983年 | 20篇 |
1981年 | 7篇 |
1980年 | 14篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1976年 | 9篇 |
1975年 | 17篇 |
1974年 | 12篇 |
1972年 | 7篇 |
1970年 | 7篇 |
1969年 | 6篇 |
1966年 | 6篇 |
排序方式: 共有1508条查询结果,搜索用时 15 毫秒
1.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
2.
U. Bolm-Audorff S. Brandenburg T. Brüning H. Dupuis R. Ellegast G. Elsner K. Franz H. Grasshoff V. Grosser L. Hanisch B. Hartmann E. Hartung K. G. Hering G. Heuchert M. Jäger J. Krämer Dr. A. Kranig E. Ludolph A. Luttmann A. Nienhaus W. Pieper K.-D. Pöhl T. Remé D. Riede G. Rompe K. Schäfer S. Schilling E. Schmitt F. Schröter A. Seidler M. Spallek M. Weber 《Trauma und Berufskrankheit》2005,7(3):211-252
Occupational diseases Nos. 2108 and 2110 correspond to intervertebral disc-related diseases of the lumbar spine from many years of carrying or lifting heavy loads, occupations in extreme postures of full flexion or oscillation of the whole body when seated, and which compel the cessation of all activities which are or could be the cause for the origin, exacerbation or recurrence of the disease. These occupational diseases came into force at the start of 1993, but there have been considerable problems in their implementation. The present Part I of the contribution is the result of the work of an interdisciplinary study group and contains medical criteria for the assessment of possibly strain-related clinical characteristics and the evaluation of other possible causes. Part II is to be published in Volume 4/2005 and will deal with questions related to forced cessation and to the assessment of the loss of earning ability. Agreement was reached in many areas related to the assessment of occupational claims. This should allow for evidence-based decision making in the future for the occupational diseases Nos. 2108 and 2110. 相似文献
3.
4.
U. Bolm-Audorff S. Brandenburg T. Brüning H. Dupuis R. Ellegast G. Elsner K. Franz H. Grasshoff V. Grosser L. Hanisch B. Hartmann E. Hartung† K. G. Hering G. Heuchert M. Jäger J. Krämer Dr. A. Kranig E. Ludolph A. Luttmann A. Nienhaus W. Pieper K. D. Pöhl T. Remé D. Riede G. Rompe K. Schäfer S. Schilling E. Schmitt F. Schröter A. Seidler M. Spallek M. Weber 《Trauma und Berufskrankheit》2005,7(4):320-332
The first part of this serial paper dealt with the medical criteria used in evaluation of the clinical picture caused by physical stress and the evaluation of other candidate causes and was published in issue no. 3/2005 (pp. 711–752) of Trauma and Berufskrankheit. This follow-up paper (II) presents criteria to be used in the evaluation of whether it is necessary to give up the occupations putting the spine at risk and in estimation of the degree of disability. 相似文献
5.
TF Leung WC Tsoi CK Li KW Chik MMK Shing PMP Yuen 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(6):705-777
We describe a 15-y-old girl with Fechtner-like syndrome, who is the first Chinese reported to have this rare syndrome. She presented with left homonymous hemianopia and neuroimaging revealed haemorrhage in both parietal and occipital lobes. Peripheral blood smear showed macrothrombocytopenia and intracytoplasmic inclusion bodies inside leucocytes. Thrombocytopenia and proteinuria responded to intravenous immunoglobulin and pulsed methylprednisolone. This case illustrates that life-threatening haemorrhage can occur in patients with Fechtner syndrome. Although there was no effective treatment reported in the literature, high dose steroid and immunoglobulin seemed to be useful in our patient. Our patient also had nephritic-nephrotic syndrome with renal insufficiency, which is unusual in adolescent female patients. 相似文献
6.
7.
8.
9.
Reported is a case of a 16-month-old girl with an isolated atrial septal defect in whom severe pulmonary hypertension has developed in 26 months in spite of an important functional gradient across the pulmonic valves at a first catheterization. Individual susceptibility to an increased pulmonary blood flow is evoked. 相似文献
10.
Robert G Kitchen Dale Mierau David Cassidy Pierre Dupuis 《The Journal of the Canadian Chiropractic Association》1988,32(1):11-15
Congenital dislocation of the hip (CDH) in an adult can accompany or cause mechanical low-back pain. This in turn, can create confusion in making the proper diagnosis. The mechanical alterations caused by CDH create an added strain to the lumbosacral spine. Manipulative treatment for back pain in these patients must not subject the dislocated hips to undue torque. 相似文献