全文获取类型
收费全文 | 1522篇 |
免费 | 84篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 57篇 |
妇产科学 | 46篇 |
基础医学 | 302篇 |
口腔科学 | 122篇 |
临床医学 | 111篇 |
内科学 | 291篇 |
皮肤病学 | 10篇 |
神经病学 | 137篇 |
特种医学 | 74篇 |
外科学 | 131篇 |
综合类 | 5篇 |
一般理论 | 1篇 |
预防医学 | 64篇 |
眼科学 | 24篇 |
药学 | 91篇 |
中国医学 | 3篇 |
肿瘤学 | 117篇 |
出版年
2023年 | 12篇 |
2022年 | 5篇 |
2021年 | 35篇 |
2020年 | 27篇 |
2019年 | 35篇 |
2018年 | 32篇 |
2017年 | 34篇 |
2016年 | 39篇 |
2015年 | 45篇 |
2014年 | 71篇 |
2013年 | 84篇 |
2012年 | 121篇 |
2011年 | 120篇 |
2010年 | 74篇 |
2009年 | 58篇 |
2008年 | 95篇 |
2007年 | 89篇 |
2006年 | 90篇 |
2005年 | 82篇 |
2004年 | 75篇 |
2003年 | 57篇 |
2002年 | 56篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 30篇 |
1998年 | 11篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1979年 | 5篇 |
1975年 | 9篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 11篇 |
1971年 | 6篇 |
1970年 | 10篇 |
1969年 | 9篇 |
1968年 | 6篇 |
1967年 | 10篇 |
1966年 | 6篇 |
1965年 | 6篇 |
排序方式: 共有1606条查询结果,搜索用时 15 毫秒
1.
Vinke Jeroen Kaper Hans J. Vissink Arjan Sharma Prashant K. 《Clinical oral investigations》2020,24(11):4019-4030
Clinical Oral Investigations - The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability... 相似文献
2.
3.
4.
5.
Anne Hagemeijer Arjan Buijs Elizabeth Smit Bart Janssen Geert-Jan Creemers Dorien Van Der Plas Gerard Grosveld 《Genes, chromosomes & cancer》1993,8(4):237-245
Leukemic cells from two patients with Philadelphia-negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M-BCR region and formation of BCR-ABL fusion mRNA with b2a2 (patient I) or b3a2 (patient 2) configuration, and 3) fluorescence in situ hybridization (FISH) demonstrated relocation of the 5′ BCR sequences from one chromosome 22 to one chromosome 9. The ABL probe hybridized to both chromosomes 9 at band q34, while two other probes which map centromeric and telomeric of BCR on 22q 11 hybridized solely with chromosome 22. For the first time, a BCR-ABL rearrangement is shown to take place on 9q34 instead of in the usual location on 22q 11. A rearrangement in the latter site is found in all Ph-positive CML and in almost all investigated CML with variant Ph or Ph-negative, BCR-positive cases. The few aberrant chromosomal localizations of BCR-ABL recombinant genes found previously were apparently the result of complex and successive changes. Furthermore in patient 2, both chromosomes 9 showed positive FISH signals with both ABL and BCR probes. Restriction fragment length polymorphism (RFLP) analysis indicated that mitotic recombination had occurred on the long arm of chromosome 9 and that the rearranged chromosome 9 was of paternal origin. The leukemic cells of this patient showed a duplication of the BCR-ABL gene, analogous to duplication of the Ph chromosome in classic CML. In addition they had lost the maternal alleles of the 9q34 chromosomal region. The lymphocytes of patient 2 carried the maternal chromosome 9 alleles and were Ph-negative as evidenced by RFLP and FISH analyses, respectively. © 1993 Wiley-Liss, Inc. 相似文献
6.
7.
E Ben-Hur R Kol R Marko E Riklis I Rosenthal 《International journal of radiation biology》1988,54(1):21-30
The response of Chinese hamster cells and human lymphocytes to the combined action of photosensitization by chloroaluminium phthalocyanine tetrasulfonate and gamma-radiation was studied using colony-forming ability and [3H]thymidine incorporation following mitogenic stimulation respectively, as endpoints. The action of both treatments was usually additive regardless of the sequence of application. However, in human lymphocytes irradiated at low temperature, the photosensitization interacted synergistically with the subsequent ionizing radiation; in this experiment the initial photosensitization reduced the yield of micronuclei produced by gamma-radiation. 相似文献
8.
Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression. 总被引:1,自引:0,他引:1
R Cihák F Kolár V Pelouch J Procházka B Ostádal J Widimsky 《Cardiovascular research》1992,26(9):845-850
OBJECTIVE: The aim was to determine left and right ventricular functional reserves and collagen concentration during the development of cardiac hypertrophy and after its regression. METHODS: Two experimental models of cardiac hypertrophy (chronic thyroxine or isoprenaline treatment of adult rats) were compared 24 h and five weeks after the agent was last given. Pressure changes in the left (right) ventricle before and after acute aortic (pulmonary artery) ligation were recorded in open chest anaesthetised animals. The difference in dP/dtmax after and before ligation was regarded as the functional reserve. The total collagen concentration was determined in both ventricles separately by means of hydroxyproline. RESULTS: Left and right ventricular weight increased by 20% and 30% respectively in the two models employed. In the thyroxine treated group, the functional reserve of the left ventricle rose very noticeably, whereas in the isoprenaline treated group it decreased. The right ventricular functional reserve did not differ from that in the controls in either of the two groups. The collagen concentration rose in the left ventricle in the isoprenaline group only. Five weeks after the last administration of the agent, cardiac mass and ventricular function did not differ from the control values in either of the models studied; the only exception was the incomplete regression of left ventricular hypertrophy and persistent structural and functional impairment of the left ventricle in the isoprenaline treated group. CONCLUSIONS: Our results indicate that hearts undergoing a comparable degree of experimental hypertrophy may have different functional and structural properties; significant differences were found between the right and left ventricular response. Regression of hypertrophy together with a reversal of ventricular function usually occurs unless the myocardium has received severe structural damage. 相似文献
9.
10.
Although considered a safe procedure, operative hysteroscopy has been reported to result in serious and even fatal complications. A fatal outcome is described after operative hysteroscopy. The attending team made a diagnosis of massive air embolism. However, HBO therapy, which is the specific treatment for air embolism, yielded only transient improvement. The pathologist's diagnosis on autopsy was anaphylaxis. These two complications must be borne in mind during the procedure, and a contingency plan developed for dealing with them should they arise. 相似文献