二十五味鬼臼丸联合微波等治疗盆腔积液疗效观察

Objective To observe clinical effect of treating pelvic effusion with twenty five tastes podophyllum pill combined with antibiotics, microwave. Methods 182 cases patients with inflammatory pelvic effusion were randomly divided into two groups. The treatment group was treated with twenty five tastes podophyllum pill combined with antibiotics、microwave, and the control group was treated with antibiotics combined with microwave. The absorption, symptoms disappeared and cure situations of pelvic effusion were observed between control group and treatment group after treatment.Results The complete absorption, symptoms disappeared and cure situations of pelvic effusion in the treatment group was significantly higher than that of the control. The total effective rate of the treatment group was 100%, and the total effective rate of the control group was 87.5%, which has a significant difference (P<0.05) .Conclusion The treatment of twenty five tastes podophyllum pill combined with antibiotics, microwave on pelvic effusion is better than western medicine.     

永久起搏器的五个常见误区

永久心脏起搏器以植入埋藏式起搏器进行人工心脏起搏,达到持久起搏作用。如今,尽管安装心脏起搏器病人不断增多,但临床调查显示,不少病人仍然对这一治疗方式缺乏科学认识。误区一:植入永久起搏器可以永久使用永久起搏器与临时起搏器相对应,临时起搏器一般在条件尚不够安装永久起搏器时或紧急情况下时使用。临时起搏器电极在体内,起搏器放置在体外,放置时间一般为1~2周,最长不超过4周,待达到治疗和预防目的后随即撤出电极导线,如仍需继续起搏治疗则应考虑植入永久起搏器。     

二十五味鬼臼丸联合后穹窿穿刺、微波治疗盆腔积液临床观察

我院自2007年10月至2008年12月治疗由炎症所致盆腔积液患者,应用二十五味鬼臼丸联合后穹窿穿刺、微波治疗取得良好疗效.现报道如下:     

二十五味鬼臼丸联合微波等治疗盆腔积液疗效观察

Objective To observe clinical effect of treating pelvic effusion with twenty five tastes podophyllum pill combined with antibiotics, microwave. Methods 182 cases patients with inflammatory pelvic effusion were randomly divided into two groups. The treatment group was treated with twenty five tastes podophyllum pill combined with antibiotics、microwave, and the control group was treated with antibiotics combined with microwave. The absorption, symptoms disappeared and cure situations of pelvic effusion were observed between control group and treatment group after treatment.Results The complete absorption, symptoms disappeared and cure situations of pelvic effusion in the treatment group was significantly higher than that of the control. The total effective rate of the treatment group was 100%, and the total effective rate of the control group was 87.5%, which has a significant difference (P<0.05) .Conclusion The treatment of twenty five tastes podophyllum pill combined with antibiotics, microwave on pelvic effusion is better than western medicine.     

西达本胺对人B淋巴瘤细胞株的作用及其机制研究

本研究旨在探讨组蛋白去乙酰化酶抑制剂(HDACI)西达本胺对3种B淋巴瘤细胞株Raji(Burkitt淋巴瘤)、Maver及Z-138(套细胞淋巴瘤)的抑制增殖和诱导凋亡的作用及其机制。以不同浓度的西达本胺及不同时间作用于体外培养的3种B淋巴瘤细胞,采用CCK-8法检测细胞的增殖;流式细胞术检测细胞的凋亡及线粒体膜电位;Western blot方法检测细胞内组蛋白H3、H4乙酰化水平及caspase-3蛋白的表达。结果表明,西达本胺可抑制这3种B淋巴瘤细胞的增殖,其抑制作用具有一定的时间和浓度依赖性,尤其能较早较快地抑制Z-138细胞的增殖;另外,西达本胺还可诱导3种B淋巴瘤细胞发生凋亡并引起细胞线粒体膜电位下降,Maver及Z-138细胞对西达本胺较Raji细胞更为敏感;西达本胺可以提高细胞内组蛋白H3、H4乙酰化水平及Maver和Z-138细胞的caspase-3活性。结论:西达本胺能够抑制B淋巴瘤细胞株的增殖,诱导细胞凋亡,其机制可能与西达本胺上调组蛋白H3、H4乙酰化水平,触发线粒体凋亡途径及活化caspase-3有关。     

二十五味鬼臼丸联合微波等治疗盆腔积液疗效观察

Objective To observe clinical effect of treating pelvic effusion with twenty five tastes podophyllum pill combined with antibiotics, microwave. Methods 182 cases patients with inflammatory pelvic effusion were randomly divided into two groups. The treatment group was treated with twenty five tastes podophyllum pill combined with antibiotics、microwave, and the control group was treated with antibiotics combined with microwave. The absorption, symptoms disappeared and cure situations of pelvic effusion were observed between control group and treatment group after treatment.Results The complete absorption, symptoms disappeared and cure situations of pelvic effusion in the treatment group was significantly higher than that of the control. The total effective rate of the treatment group was 100%, and the total effective rate of the control group was 87.5%, which has a significant difference (P<0.05) .Conclusion The treatment of twenty five tastes podophyllum pill combined with antibiotics, microwave on pelvic effusion is better than western medicine.     

PET-CT在霍奇金淋巴瘤治疗中的作用

 　准确的影像学检查对淋巴瘤的优化治疗至关重要。通过提供解剖学和功能学信息,PET-CT从根本上改变了包括霍奇金淋巴瘤在内的淋巴瘤分期、疗效监测与评估以及治疗方法的选择。与标准检查方法联合应用,PET-CT可以提高病变部位检测的敏感性,监测治疗期间疾病的缓解程度,区分纤维坏死性瘢痕组织和有活性的肿瘤组织,提供预后信息。PET-CT已成为现代淋巴瘤治疗不可或缺的一部分,但是作为相对较新的诊断技术,其全部优点和缺点没有完全研究清楚。根据临床试验的最新结果和单中心应用PET-CT的经验,从临床角度探讨PET-CT的优点和缺点。     

二十五味鬼臼丸联合微波等治疗盆腔积液疗效观察

目的 观察二十五味鬼臼丸联合抗生素、微波治疗盆腔积液的临床疗效.方法 将182例炎性盆腔积液患者分为两组,治疗组94例采用二十五味鬼臼丸联合抗生素、微波治疗,对照组88例采用抗生素联合微波治疗.观察两组治疗后盆腔积液的吸收及症状改善情况.结果 二十五味鬼臼丸联合抗生素、微波治疗盆腔积液从积液完全吸收情况、症状消失情况、治愈率等方面均优于对照组.治疗组总有效率为100%,对照组总有效率87.5%.两组比较有显著性差异(P<0.05).结论 二十五味鬼臼丸联合抗生素、微波治疗盆腔积液有效.     

116例老年晚期非小细胞肺癌一线化疗或易瑞沙治疗分析

目的 比较晚期老年非小细胞肺癌(non-small cell lung cancer,NSCLC)患者使用单药化疗、含铂化疗和易瑞沙一线治疗的疗效和副反应.方法 回顾某院从2006年5月～2009年6月收治的老年(＞70岁)晚期非小细胞肺癌患者,纳入ECOG评分0～1分的116例患者.其中33例接受易瑞沙治疗,39例接受单药化疗,44例接受含铂双药化疗.结果 在116例患者中,易瑞沙、单药化疗、含铂双药化疗的3组客观缓解率(objective response rate,ORR)分别为24.2％、5.1％和13.6％,P=0.064.易瑞沙、单药化疗、双药化疗3组的中位无疾病进展生存时间(failure-free survival,PFS)分别为4、2、3月,P=0.005.在两两比较时,易瑞沙较单药化疗及双药组均延长了中位PFS,差异有统计学意义(P=0.005,P=0.025).易瑞沙组的总中位生存时间(overall survival,OS)为10月,单药化疗组8月,双药化疗组12月(P=0.039).在两两比较中,仅有双药化疗比单药延长了中位OS (P=0.01).3～4度不良反应发生率分别是易瑞沙组:4例(12.1％),单药化疗组:9例(23.1％),双药化疗组:20例(45.5％),P＜ 0.001.没有治疗相关性死亡发生.结论 含铂双药化疗一线治疗ECOG评分较好的老年NSCLC比单药化疗可显著延长OS,且双药化疗可以耐受.易瑞沙和双药化疗的OS差异无统计学意义,但耐受性更好.以上结果有待进行前瞻性临床试验进一步证实.