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1.
Roengsumran S Musikul K Petsom A Vilaivan T Sangvanich P Pornpakakul S Puthong S Chaichantipyuth C Jaiboon N Chaichit N 《Planta medica》2002,68(3):274-277
A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474. 相似文献
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Nuttaporn Parinyaprom Areerat Nirunsittirat Patchanee Chuveera Sakarat Na Lampang Tanida Srisuwan Thanapat Sastraruji Puangporn Bua-on Sophon Simprasert Issaraporn Khoipanich Thitida Sutharaphan Suthida Theppimarn Narumol Ue-srichai Waritorn Tangtrakooljaroen Papimon Chompu-inwai 《Journal of endodontics》2018,44(3):341-348
Introduction
This study aimed to compare the success rates of direct pulp capping (DPC) by using either ProRoot Mineral Trioxide Aggregate (MTA) or Biodentine in the cariously exposed permanent teeth of 6- to 18-year-old patients. Gray discoloration was also evaluated.Methods
Fifty-nine cariously exposed permanent teeth, including teeth with diagnosis of normal pulp, reversible pulpitis, or irreversible pulpitis, early periapical involvement, and exposure size of up to 2.5 mm, were included. Each patient with only 1 cariously exposed tooth was randomly allocated to DPC with either ProRoot MTA (n = 30) or Biodentine (n = 29). Patients were recalled every 6 months. Clinical and radiographic examinations were used to determine success.Results
Fifty-five patients (mean age, 10 ± 2 years), 27 treated with ProRoot MTA and 28 with Biodentine, were included in the analysis. At mean follow-up of 18.9 ± 12.9 months, the success rate was 92.6% with ProRoot MTA and 96.4% with Biodentine (P > .05; difference, 4%; 95% confidence interval [CI], –8% to 16%). Biodentine was non-inferior to ProRoot MTA. Failures were distributed equally in all categories of pulpal diagnosis and occurred in teeth with no periapical involvement and small exposures (0.5 mm). The survival probabilities of DPC with ProRoot MTA and Biodentine were 0.92 (95% CI, 0.73–0.98) and 0.96 (95% CI, 0.80–0.99). No significant difference was observed between them (P > .05). Gray discoloration was observed only with ProRoot MTA (55%).Conclusions
Biodentine was non-inferior to ProRoot MTA when used as a DPC material for cariously exposed permanent teeth of 6- to 18-year-old patients. However, Biodentine did not cause any gray discoloration in this study. 相似文献3.
Labda-7,12( E),14-triene-17-oic acid, previously isolated from Croton oblongifolius, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12( E),14-triene-17-al, 17-hydroxylabda-7,12( E),14-triene, 17-acetoxylabda-7,12( E),14-triene, 15-hydroxylabda-7,13( E)-diene-17,12-olide, labda-7,13( E)-diene-17,12-olide, and 12,17-dihydroxylabda-7,13( E)-diene showed non-specific, moderate, cytotoxicity against all cell lines, whereas the other compounds were inactive. 相似文献
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Pornpakakul S Liangsakul J Ngamrojanavanich N Roengsumran S Sihanonth P Piapukiew J Sangvichien E Puthong S Petsom A 《Archives of pharmacal research》2006,29(2):140-144
Four xanthones were isolated from mycelia of Emericella variecolor, an endophytic fungus isolated from the leaves of Croton oblongifolius. Their structures were elucidated by spectroscopic analysis to be shamixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone methanoate, and tajixanthone hydrate. All compounds were tested for cytotoxic activity against various human tumor cell lines including gastric carcinoma, colon carcinoma, breast carcinoma, human hepatocarcinoma, and lung carcinoma. The antitumor activities of these xanthones were compared with that of doxorubicin hydrochloride, a chemotherapeutic substance. All of them showed moderate activities and were selective against gastric carcinoma, colon carcinoma, and breast carcinoma. Only tajixanthone hydrate exhibited moderate activity against all cancer cell lines. Furthermore, under the test conditions it was found that 14-methoxytajixanthone-25-acetate and tajixanthone hydrate are almost as active as doxorubicin hydrochloride against gastric carcinoma (KATO3) and breast carcinoma (BT474). 相似文献
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Arpijuntarangkoon J Rojnuckarin P Muanpasitporn C Kaeothip S Sangvanich P Intragumtornchai T 《Platelets》2007,18(4):266-272
Green pit viper (Trimeresurus albolabris) venom contains a variety of C-type lectin-like proteins (CLPs) causing platelet aggregation and consumptive thrombocytopenia in biting victims. Alboaggregin B (AL-B), a heterodimeric glycoprotein (Gp) Ib-binding protein, was purified from the venom, but there is no reported cDNA sequence and the platelet agglutination mechanism is poorly understood. The full-length AL-B beta clone was obtained from T. albolabris venom gland cDNA library. AL-B alpha was, later, derived using 3'-RACE based on the conserved sequence. In this study, purified AL-B dimer agglutinated human platelets with the EC(50) of 180 nM and was completely inhibited by anti GpIb antibody. MALDI ToF mass spectroscopy found no glycosylation. The peptide mass fingerprints were matched with deduced amino acid sequences of cloned genes. AL-B alpha and beta contained 156 and 146 amino acid, respectively, including 23-residue signal peptides. AL-B beta showed the conserved hydrophilic patches, putative sites for GpIb binding. Furthermore, there was another conserved motif (SRTY) exclusively in platelet-agglutinating AL-B, TSV-GPIb-BP and Mamushigin. We propose that these three CLPs may function as bivalent adhesive proteins linking two GpIb molecules on adjacent platelets. 相似文献
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Tansuwan S Pornpakakul S Roengsumran S Petsom A Muangsin N Sihanonta P Chaichit N 《Journal of natural products》2007,70(10):1620-1623
Two novel benzoquinone metabolites, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione ( 1) and xylariaquinone A ( 2) together with two known compounds were isolated from an endophytic fungus, Xylaria sp. Their structures were assigned by analysis of spectroscopic data, and the structures of 1 and 3 were also confirmed by single-crystal X-ray data. Compounds 1 and 2 showed in vitro activity against Plasmodium falciparum, K1 strain, with IC 50 values of 1.84 and 6.68 microM and cytotoxicity against African green monkey kidney fibroblasts (Vero cells) with IC 50 values of 1.35 and >184 microM, respectively. 相似文献
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Pudhom K Vilaivan T Ngamrojanavanich N Dechangvipart S Sommit D Petsom A Roengsumran S 《Journal of natural products》2007,70(4):659-661
Four novel furanocembranoids (1-4) were isolated from the stem bark of Croton oblongifolius. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1, 3, and 4 exhibited good cytotoxicity against several human tumor cell lines. 相似文献