全文获取类型
收费全文 | 4433篇 |
免费 | 270篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 128篇 |
妇产科学 | 49篇 |
基础医学 | 601篇 |
口腔科学 | 104篇 |
临床医学 | 352篇 |
内科学 | 1172篇 |
皮肤病学 | 183篇 |
神经病学 | 485篇 |
特种医学 | 106篇 |
外科学 | 449篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 239篇 |
眼科学 | 96篇 |
药学 | 321篇 |
中国医学 | 12篇 |
肿瘤学 | 349篇 |
出版年
2023年 | 41篇 |
2022年 | 25篇 |
2021年 | 96篇 |
2020年 | 60篇 |
2019年 | 106篇 |
2018年 | 127篇 |
2017年 | 92篇 |
2016年 | 91篇 |
2015年 | 102篇 |
2014年 | 126篇 |
2013年 | 143篇 |
2012年 | 248篇 |
2011年 | 274篇 |
2010年 | 178篇 |
2009年 | 159篇 |
2008年 | 263篇 |
2007年 | 234篇 |
2006年 | 237篇 |
2005年 | 238篇 |
2004年 | 223篇 |
2003年 | 201篇 |
2002年 | 212篇 |
2001年 | 128篇 |
2000年 | 97篇 |
1999年 | 89篇 |
1998年 | 40篇 |
1997年 | 45篇 |
1996年 | 45篇 |
1995年 | 23篇 |
1994年 | 28篇 |
1993年 | 30篇 |
1992年 | 77篇 |
1991年 | 51篇 |
1990年 | 68篇 |
1989年 | 60篇 |
1988年 | 46篇 |
1987年 | 48篇 |
1986年 | 38篇 |
1985年 | 48篇 |
1984年 | 36篇 |
1983年 | 14篇 |
1982年 | 14篇 |
1979年 | 18篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1974年 | 19篇 |
1973年 | 24篇 |
1972年 | 15篇 |
1970年 | 17篇 |
1967年 | 12篇 |
排序方式: 共有4722条查询结果,搜索用时 31 毫秒
1.
2.
3.
Zuo Shogo Sho Masayuki Sawai Toshio Kanehiro Hiromichi Maeda Kosaku Yoshida Makiko Tsukada Ryo Nomura Motonari Okuyama Hiroomi 《Pediatric surgery international》2020,36(2):137-143
Pediatric Surgery International - The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was... 相似文献
4.
5.
6.
7.
Kenichi Okubo Masashi Kobayashi Hiromasa Morikawa Eiichi Hayatsu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(7):268-272
Objective: Induction chemoradiotherapy followed by anatomical resection is a current therapeutic strategy for non-small-cell lung cancer
with mediastinal node involvement. Dense peritracheal fibrosis and sclerosis after chemoradiotherapy cause difficult mediastinal
node dissection. We evaluated a novel technique to make the mediastinal node dissection easier after induction therapy. Methods: At the end of mediastinoscopic node biopsy for staging of lung cancer, cotton-type collagen was inserted anterior and lateral
to the trachea in patients with pathologically confirmed mediastinal node involve-ment (n=45). The induction therapy consisted
of concurrent use of platinum-based chemotherapy and hyperfractionated radiotherapy. After the chemoradiotherapy all patients
underwent a pulmonary resection with complete mediastinal node dissection 7–12 weeks after the collagen insertion. Surgical
findings of the mediastinum and the time for node dissection were compared with those without collagen insertion at mediastinoscopy
after chemoradiotherapy (n=5). Results: All five patients without collagen insertion showed sclerotic and fibrotic change of mediastinal nodes with severe adhesion
to the trachea. In 42 of 45 patients with collagen insertion (93.3%) the collagen remained unabsorbed and separated the mediastinal
nodes from the trachea. Mediastinal node dissection was easily accomplished by removing mediastinal tissues lateral and anterior
to the collagen. The rate of mediastinal node separation was significantly higher with collagen insertion than without (p<
0.0001). The times for node dissection in patients with and without collagen insertion showed no significant difference. Conclusion: Cotton-type collagen insertion at staging mediastinoscopy for lung cancer separates the mediastinal nodes from the trachea
and makes the node dissection easier after induction chemoradiotherapy. 相似文献
8.
9.
Yuko Kamio Yurika Saito Naoki Utoguchi Masuo Kondoh Naoya Koizumi Makiko Fujii Yoshiteru Watanabe 《Journal of controlled release》2005,102(3):563-568
Some physiological substances, including acetylcholine and nitric oxide, are useful candidates for stimulation of intestinal absorption of drugs. In the present study, we elucidated the ability of epinephrine (Epi) to stimulate the intestinal absorption of drugs. We evaluated the ability of Epi to enhance absorption of macromolecules using dextran (Mw 4000 Da), which is poorly absorbed from the intestine, as a model compound in situ in a closed loop of the rat jejunum. Treatment of the jejunum with Epi resulted in significant increase in absorption of dextran in a dose-dependent fashion. The area under the curve (AUC) from 0 to 4 h in the Epi-treated jejunum was 13-fold higher than that in the vehicle-treated jejunum. The absorption-enhancing activity of Epi was 40-fold higher than that of caprate, a clinically used absorption-enhancer of drugs. In the experimental conditions used in this study, histological injury of the mucosa and perturbation of the mucosal membrane were not observed in the Epi-treated jejunum. Treatment with an antagonist of alpha-adrenergic receptors attenuated the stimulation of intestinal absorption by Epi, and treatment with an agonist of alpha-adrenergic receptors resulted in enhancement of intestinal absorption. While an antagonist of beta-adrenergic receptors enhanced the absorption-enhancing effect of Epi, an agonist of beta-adrenergic receptors stimulated intestinal absorption. These results indicate that stimulation of adrenergic receptors may be a novel strategy for intestinal absorption of drugs. 相似文献
10.
Yuhei Okubo Junji Yonese Satoru Kawakami Sinya Yamamoto Yoshinobu Komai Hideki Takeshita Yuichi Ishikawa Iwao Fukui 《International journal of urology》2007,14(9):854-855
Renal cell carcinoma (RCC) causes many kinds of symptoms such as hypercalcemia, hypertension, polycythemia and fever. Here we describe a rare case of RCC presenting with a persistent cough. After radical nephrectomy, the obstinate cough disappeared. When the tumor recurred locally, the cough also recurred. Furthermore, the cough disappeared completely again after the removal of the recurrent tumor. Although all the clinical findings suggested that the RCC caused the cough, we could not identify a specific humoral substance responsible for the cough. 相似文献