全文获取类型
收费全文 | 61篇 |
免费 | 1篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 12篇 |
基础医学 | 3篇 |
口腔科学 | 14篇 |
临床医学 | 2篇 |
内科学 | 8篇 |
特种医学 | 1篇 |
外科学 | 6篇 |
综合类 | 2篇 |
预防医学 | 9篇 |
药学 | 1篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2017年 | 4篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 4篇 |
2011年 | 10篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2007年 | 2篇 |
2006年 | 3篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1996年 | 1篇 |
1987年 | 1篇 |
1933年 | 1篇 |
排序方式: 共有62条查询结果,搜索用时 828 毫秒
1.
2.
3.
Evidence for activation of cellular immune responses in patients with acute hepatitis E. 总被引:1,自引:0,他引:1
Sita Naik Rakesh Aggarwal Subhash R Naik Sunita Dwivedi Sudha Talwar S K Tyagi S D Duhan P Coursaget 《Indian journal of gastroenterology》2002,21(4):149-152
INTRODUCTION: Although acute hepatitis E virus (HEV) infection is known to induce IgM and IgG humoral host immune responses, little is known about occurrence of cellular responses in this infection. We looked for evidence of lymphocyte sensitization to HEV peptides in patients with acute HEV infection. METHODS: peripheral blood lymphocytes were obtained from patients with acute hepatitis E and healthy controls. Proliferation of these lymphocytes in the presence of each of seven peptides with amino acid sequences corresponding to open reading frames 2 and 3 proteins of HEV (3 and 4 peptides, respectively) were studied; no peptide was added to control wells. Proliferative responses with stimulation indices exceeding 3.0 were taken as positive. RESULTS: More patients showed reactivity to two or more HEV peptides than did controls (11/21 vs 5/22, p<0.05). Reactivity to one peptide corresponding to open reading frame 2 of HEV was more frequent in patients than in controls (7/21 vs 1/22, p<0.05). CONCLUSION: Our results show that lymphocytes of patients with acute hepatitis E show sensitization to HEV peptides. This may have significance in understanding the pathogenetic mechanisms of liver injury in this infection. 相似文献
4.
5.
6.
7.
8.
Purpose Transanal endoscopic microsurgery has emerged as an improved method of transanal excision of neoplasms because its enhanced
visibility, superior optics, and longer reach permit a more complete excision and precise closure. This study will show that
transanal endoscopic microsurgical treatment of pT1 rectal cancers is safe and achieves low local recurrence and high survival
rates.
Methods Retrospective review performed of all pT1 rectal cancers treated by a single surgeon (TS) using transanal endoscopic microsurgery
between 1991 and 2003. Patient age, gender, tumor distance from the anal verge, lesion size, operative time, blood loss, complications,
recurrence, and survival rates were prospectively recorded.
Results Fifty-three patients (average age, 65.6 (range, 31–89) years) were studied. Forty-nine percent were male. Average tumor distance
from the anal verge was 7 (range, 0–13) cm; average size was 2.4 (range, 1–10) cm. Radiation and/or chemotherapy were not
administered. Sixteen patients had pT1 lesions removed piecemeal during colonoscopy; there was no residual tumor after transanal
endoscopic microsurgical resection of the polyp site. Mean follow-up was 2.84 years. Fifty-one percent had longer than two-year
follow-up. For the entire group, there were four recurrences (7.5 percent) occurring at 9 months, 15 months, 16 months, and
11 years. Two were treated with abdominoperineal resection, one with low anterior resection, and one with fulguration alone.
There were no recurrences in the 16 patients who had excision of the polypectomy site. If excluded, recurrence was 11 percent
(4/37). Patients were examined at three-month intervals for the first two years and every six months thereafter. There have
been no cancer-related deaths.
Conclusions Transanal endoscopic microsurgical resection of pT1 rectal cancers yields low recurrence rates. Close follow-up permits curative
salvage for those that do recur. Transanal excision remains a viable option.
Read at the meeting of The American Society of Colon and Rectal Surgeons, Dallas, Texas, May 8 to 13, 2004.
Reprints are not available. 相似文献
9.
10.