全文获取类型
收费全文 | 3756篇 |
免费 | 231篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 199篇 |
妇产科学 | 51篇 |
基础医学 | 494篇 |
口腔科学 | 191篇 |
临床医学 | 298篇 |
内科学 | 918篇 |
皮肤病学 | 75篇 |
神经病学 | 166篇 |
特种医学 | 520篇 |
外科学 | 319篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 288篇 |
眼科学 | 37篇 |
药学 | 194篇 |
中国医学 | 46篇 |
肿瘤学 | 140篇 |
出版年
2023年 | 14篇 |
2022年 | 45篇 |
2021年 | 92篇 |
2020年 | 68篇 |
2019年 | 94篇 |
2018年 | 118篇 |
2017年 | 66篇 |
2016年 | 80篇 |
2015年 | 101篇 |
2014年 | 121篇 |
2013年 | 163篇 |
2012年 | 191篇 |
2011年 | 202篇 |
2010年 | 156篇 |
2009年 | 124篇 |
2008年 | 146篇 |
2007年 | 138篇 |
2006年 | 120篇 |
2005年 | 120篇 |
2004年 | 80篇 |
2003年 | 66篇 |
2002年 | 94篇 |
2001年 | 49篇 |
2000年 | 65篇 |
1999年 | 52篇 |
1998年 | 143篇 |
1997年 | 126篇 |
1996年 | 130篇 |
1995年 | 97篇 |
1994年 | 81篇 |
1993年 | 83篇 |
1992年 | 41篇 |
1991年 | 29篇 |
1990年 | 30篇 |
1989年 | 78篇 |
1988年 | 51篇 |
1987年 | 67篇 |
1986年 | 55篇 |
1985年 | 64篇 |
1984年 | 37篇 |
1983年 | 42篇 |
1982年 | 40篇 |
1981年 | 27篇 |
1980年 | 39篇 |
1979年 | 23篇 |
1978年 | 18篇 |
1977年 | 23篇 |
1976年 | 27篇 |
1975年 | 26篇 |
1973年 | 12篇 |
排序方式: 共有4017条查询结果,搜索用时 93 毫秒
1.
Sissa Brito dos Santos Aurélia Bertholet-Thomas Marine Butin Laurence Dubourg Alain Fouilhoux Justine Bacchetta 《Archives de pédiatrie》2021,28(4):338-341
The main clinical features of tyrosinemia type 1 usually appear in the first months of life, including fever, diarrhea, vomiting, liver involvement, growth failure, and renal proximal tubulopathy with subsequent hypophosphatemic rickets. An early diagnosis is crucial in order to provide specific management and to prevent complications. Here, we report on two cases referred primarily to pediatric nephrologists for the diagnosis of “neonatal tubulopathy” and management of “X-linked hypophosphatemia (XLH),” respectively. Our aim is to emphasize that (1) even a mixed tubulopathy can reveal tyrosinemia, and (2) tyrosinemia is a classic differential diagnosis of XLH that should not be forgotten, especially in the era of the anti-FGF23 burosumab. 相似文献
2.
Andressa A.F.L. Maciel Reinaldo B. Ori Manuel B. Braga-Neto Andra B. Braga Eunice B. Carvalho Herene B.M. Lucena Gerly A.C. Brito Richard L. Guerrant Aldo A.M. Lima 《Toxicon》2007,50(8):1027-1040
Vitamin A (retinol), a fat-soluble vitamin, is an essential nutrient for the normal functioning of the visual system, epithelial cell integrity and growth, immunity, and reproduction. Our group has investigated the effect of high doses of oral vitamin A on early childhood diarrhea in our prospective community-based studies from Northeast Brazil and found a beneficial role in reducing the mean duration but not incidence of diarrheal episodes. In this study, we explored the role of retinol supplementation in intestinal cell lines following Clostridium difficile toxin A (TxA) challenge. C. difficile is the most common anaerobic pathogen borne with antibiotic-borne diarrhea and pseudomembranous colitis. Since retinol is critical for the integrity of tight junctions and to modulate the cell cycle, we have focused on changes in transepithelial electrical resistance (TEER) in Caco-2, a more differentiated intestinal cell line, and on models of cell proliferation, migration and viability in IEC-6 cells, an undifferentiated crypt cell line, following TxA injury. In this model, retinol therapy reduced apoptosis, improved cell migration and proliferation, and prevented the reduction in TEER, following C. difficile TxA challenge in a glutamine-free medium. These results suggest the role of retinol in protecting intestinal epithelial barrier function from C. difficile TxA enterotoxic damage. 相似文献
3.
Marco Antonio Botelho Rinaldo Araujo dos Santos Jose Galberto Martins Cintia Oliveira Carvalho Mabel Calina Paz Cláudio Azenha Ronaldo Sousa Ruela Dinalva Brito Queiroz Wagner Sousa Ruela Gloria Marinho Francisca Isabel Ruela 《Phytotherapy research : PTR》2009,23(9):1214-1219
An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy of a Lippia sidoides essential oil (EO) 1% mouthrinse compared with chlorhexidine 0.12% mouthrinse, applied two times daily for 1 week, in the treatment of dental plaque and gingivitis. Fifty‐five patients were included in the study. The efficacy variables were the colony count of Streptococcus mutans from the stimulated saliva and periodontal indices on days 0, 7 and 30 after commencement of therapy. Twenty eight patients received chlorhexidine mouthrinse (Periogard®) and 27 Lippia sidoides essential oil mouthrinse (Cepakill®). The clinical and microbiological parameters were significantly reduced by both mouthrinses. No significant difference was seen between the two groups (p > 0.05). There was a significant reduction in the colony count of S. mutans in both groups (p < 0.05). Chlorhexidine treatment reduced more efficiently than L. sidoides, however, no statistical difference was seen, the efficacy of both groups was similar (p = 0.3). The results indicate that Chlorhexidine mouthrinse reduced plaque index, gingival bleeding and the number of CFU (colonies forming units) more efficiently than L. sidoides but did not reach statistical significance. This study demonstrated that Lippia sidoides EO mouthrinse is effective in reducing microbial plaque and gingival inflammation. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
4.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
5.
Heloísio de Rezende Leite Guilherme Silvério de Oliveira Hélio Henrique de Araújo Brito 《American journal of orthodontics and dentofacial orthopedics》2005,128(2):241-251
This case report demonstrates how extracting a maxillary deciduous canine affects the eruption path of a labially displaced ectopically erupting permanent canine. A long-term follow-up is presented, and the biologic mechanisms are discussed. 相似文献
6.
7.
8.
9.
10.