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Odontology - The aim was to explore the fracture-behavior, survival and marginal-microgaps within the root-canal of immature anterior teeth restored with different fiber-reinforced post-core...  相似文献   
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Clinical Oral Investigations - The aim of this in vitro study was to investigate the fatigue survival and fracture behavior of endodontically treated (ET) premolars restored with different types of...  相似文献   
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Purpose

Visual electrophysiology is routinely used to detect the visual complications of multiple sclerosis, but the analysis mostly focuses on visual evoked potential (VEP) and especially the P100 component. Our goal was to analyze the components and waveform alterations of VEPs and pattern electroretinograms (PERGs) in patients with multiple sclerosis (MS) with good vision.

Methods

The main VEP and PERG components of 85 patients with MS were analyzed in two groups: 38 patients who had optic neuritis in their history (ON group) and 47 patients who had never had optic neuritis (MS group). The results were compared against a control group of 47 healthy subjects.

Results

Both VEP and PERG alterations occurred in a greater number of patients than expected, and these alterations were not necessarily linked to ON in the history or a deterioration of visual acuity.

Conclusions

Both VEP and PERG can detect dysfunction in the visual system in MS, even if the patient has no subjective symptoms. Even if PERG is not routinely used in neuro-ophthalmology, the results suggest that PERG assessment may provide useful information describing the retinal defect in MS.
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Zusammenfassung In einer norddeutschen Familie, die cyanotische Individuen in 3 Generationen aufweist, wurde HbM als Ursache der Cyanose festgestellt. Ein Kind konnte von Geburt an beobachtet werden; es entwickelte erst im Ablauf einiger Wochen die charakteristische Cyanose. Daraus war abzuleiten, daß die Anomalie in der-Kette des Hämoglobins liegen mußte. Dies ließ sich im Hybridisierungsexperiment mit Hundehämoglobin als zutreffend erweisen. Die Untersuchung der Peptide der durch Gegenstromverteilung aus Globin isolierten-Kette mittels fingerprint ergab ein anomales PeptidT7. Die quantitative Aminosäureanalyse dieses Peptids zeigte, daß darin Histidin fehlte, dagegen Tyrosin vorhanden war, woraus folgt, daß in Position 63 der-Kette ein Histidin-Tyrosin-Austausch vorliegt. Das entspricht den Verhältnissen in HbM Saskatoon.
Summary In a north german family which shows cyanotic members in three generations, it was found that HbM was the cause of the cyanosis. One child was observed from birth. It developed the characteristic cyanosis within a few weeks indicating that the anomaly was in the-chain of the haemoglobin. This was shown to be correct by hybridisation of the haemoglobin with dog haemoglobin. The investigation of the tryptic peptides of the-chain isolated from globin by counter-current distribution, by fingerprint, gave an anomalous peptideT7. Quantitative amino-acid analysis of this peptide showed that it lacked histidine but contained tyrosine instead, from which it follows that there is an exchange of tyrosine for histidine in position 63 of the-chain. This corresponds to the arrangement in HbM Saskatoon.


Mit teilweiser Unterstützung durch die Deutsche Forschungsgemeinschaft.  相似文献   
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