磷酸三钙生物陶瓷在牙周植骨术中的初步应用

在细胞毒性试验与动物实验基础上,选用国内试制的磷酸三钙陶瓷(TPC)粉末,植人4名牙周病患者的6个骨缺损内。结果术后24周内,植入部牙周组织无明显炎症与材料排异迹象,牙周袋均变浅,附着水平均增加。X线片示植入缺损内皆有新骨形成,骨吸收阴影面积减少均效为41.69%,牙槽骨高度冠向净增加为根长的30.90%(p<0.05)。TPC具有促进牙周病骨缺损修复的潜能,TPC材料来源充足,使用与保存简便,能重复消毒利用,可作为牙周植骨术的骨材。     

生物陶瓷修复牙周骨缺损研究进展

本文主要就用于修复牙周骨缺损的生物陶瓷之选择,动物实验和临床研究以及有关的生物陶瓷特性加以综述。一、问题的提出修复牙周病引起的骨缺损一直是牙周病治疗的棘手问题。用自体骨或异体骨移植诱导骨形成以修复骨缺损,是临床上常用的有一定疗效的方法之一。然而,用自体骨移植,口内取骨量有限,要取得足够的自体骨,常需自其它部位进行手术取骨。这既增加患者痛苦,也不易为患者所接受。术后可能发生牙根吸收和粘连。异体骨移植克服了自体骨移植的缺点,但异体骨有抗原性,使用前需经一定的处理,贮藏需一定的条     

EXPERIMENTAL STUDY ON APPLICATION OF CALCIUM PHOSPHATE BIOCERAMIC IN PERIODONTAL OSSEOUS DEFECTS

After cytotoxicity test of materials, the application of tricalcium phosphate ceramic (TPC) powder and calcium pyrophosphate ceramic (CPC) powder were evaluated histopathologically in dogs. 2-wall defects (crater) were created surgically in eighteen adult mongrel dogs and ceramic materials were placed into the dejects. On each side of jaw there remained a defect not filling with ceramic and served as control. The dogs were sacrificed at 2nd. 4th, 8th, 16th, 24th and 32nd postoperative week for histological evaluation. Histologically, all materials showed excellent biocompatibility and bone affinity. New bone was found directly deposited on the ceramic particles, and new bone grew more coronally in implant sites than in control sites. The bone affinity of TPC was better than that of CPC. These materials appeared to have osteoconductive effect. At 32nd postoperative week, there was still some remnants of ceramic. According to the results, the authors believe that calcium phosphate ceramic, especially TPC. has the potential to be an alternative to bone graft. The biocompatibility, function and bioresorbability of bioceramic are discussed.