全文获取类型
收费全文 | 5137篇 |
免费 | 316篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 87篇 |
妇产科学 | 31篇 |
基础医学 | 698篇 |
口腔科学 | 76篇 |
临床医学 | 325篇 |
内科学 | 1450篇 |
皮肤病学 | 104篇 |
神经病学 | 423篇 |
特种医学 | 211篇 |
外科学 | 875篇 |
综合类 | 24篇 |
一般理论 | 3篇 |
预防医学 | 119篇 |
眼科学 | 65篇 |
药学 | 325篇 |
中国医学 | 22篇 |
肿瘤学 | 609篇 |
出版年
2024年 | 5篇 |
2023年 | 63篇 |
2022年 | 52篇 |
2021年 | 224篇 |
2020年 | 132篇 |
2019年 | 187篇 |
2018年 | 244篇 |
2017年 | 123篇 |
2016年 | 153篇 |
2015年 | 156篇 |
2014年 | 197篇 |
2013年 | 231篇 |
2012年 | 409篇 |
2011年 | 474篇 |
2010年 | 240篇 |
2009年 | 195篇 |
2008年 | 325篇 |
2007年 | 343篇 |
2006年 | 328篇 |
2005年 | 305篇 |
2004年 | 280篇 |
2003年 | 249篇 |
2002年 | 233篇 |
2001年 | 40篇 |
2000年 | 22篇 |
1999年 | 30篇 |
1998年 | 35篇 |
1997年 | 27篇 |
1996年 | 20篇 |
1995年 | 20篇 |
1994年 | 36篇 |
1993年 | 27篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 8篇 |
1987年 | 13篇 |
1986年 | 8篇 |
1985年 | 3篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有5488条查询结果,搜索用时 31 毫秒
1.
2.
3.
Yasushi Sawayama Hidehiro Itonaga Takuya Fukushima Nobuaki Nakano Hiroshi Fujiwara Atae Utsunomiya Takahiro Fukuda Toshihiro Miyamoto Tetsuya Eto Kaname Miyashita Hirohisa Nakamae Masao Ogata Atsushi Yamanoha Yasuhiko Miyazaki Junya Kanda Yoshiko Atsuta Koji Kato ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation 《American journal of hematology》2019,94(5):E143-E146
4.
Eriko Yanagida Hiroaki Miyoshi Mai Takeuchi Noriaki Yoshida Kazutaka Nakashima Kyohei Yamada Takeshi Umeno Yasumasa Shimasaki Takuya Furuta Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):680-688
The interaction of CD47 and signal-regulatory protein alpha (SIRPα) induces “don't eat me signal”, leading suppression of phagocytosis. This signal can affect the clinical course of malignant disease. Although CD47 and SIRPα expression are associated with clinicopathological features in several neoplasms, the investigation for adult T-cell leukemia/lymphoma (ATLL) has not been well-documented. This study aimed to declare the association between CD47 and SIRPα expression and clinicopathological features in ATLL. We performed immunostaining on 73 biopsy samples and found that CD47 is primarily expressed in tumor cells, while SIRPα is expressed in non-neoplastic stromal cells. CD47 positive cases showed significantly higher FoxP3 (P = .0232) and lower CCR4 (P = .0214). SIRPα positive cases presented significantly better overall survival than SIRPα negative cases (P = .0132). SIRPα positive cases showed significantly HLA class I (P = .0062), HLA class II (P = .0133), microenvironment PD-L1 (miPD-L1) (P = .0032), and FoxP3 (P = .0229) positivity. In univariate analysis, SIRPα expression was significantly related to prognosis (Hazard ratio [HR] 0.470; 95% confidence interval [CI] 0.253-0.870; P = .0167], although multivariate analysis did not show SIPRα as an independent prognostic factor. The expression of SIRPα on stromal cells reflects activated immune surveillance mechanism in tumor microenvironment and induce good prognosis in ATLL. More detailed studies for gene expression or genomic abnormalities will disclose clinical and biological significance of the CD47 and SIRPα in ATLL. 相似文献
5.
6.
7.
8.
Hisato Takagi Toshiyuki Tanabashi Norikazu Kawai Takuya Umemoto 《European journal of cardio-thoracic surgery》2007,32(2):400; author reply 400-400; author reply 401
9.
10.
Nobuyuki Takemura Yasuhiko Sugawara Takuya Hashimoto Nobuhisa Akamatsu Yoji Kishi Sumihito Tamura Masatoshi Makuuchi 《Liver transplantation》2005,11(3):356-360
The incidence of hepatic venous stenosis is higher in partial liver transplantation. New methods for hepatic venous reconstruction in left liver transplantation, which secure wide anastomosis, were devised and are reported here. In the graft, the right side of the middle hepatic vein or the left side of the left hepatic vein was cut longitudinally and a rectangular-shaped vein patch was attached for venoplasty. In the recipient, after the left and middle hepatic veins were joined, the right side of the middle hepatic vein was cut toward the closed right hepatic vein, making a horizontal cavotomy for anastomosis. Of 92 patients who underwent conventional hepatic vein reconstruction, 3 were complicated by hepatic venous stenosis (median follow-up 43 months). By contrast, there were no hepatic vein complications in the 20 patients who underwent the new technique (7 months). The current method appears to be technically feasible for outflow reconstruction in left liver graft transplantation. 相似文献