全文获取类型
收费全文 | 5541篇 |
免费 | 557篇 |
国内免费 | 214篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 128篇 |
妇产科学 | 247篇 |
基础医学 | 704篇 |
口腔科学 | 72篇 |
临床医学 | 656篇 |
内科学 | 1072篇 |
皮肤病学 | 101篇 |
神经病学 | 431篇 |
特种医学 | 378篇 |
外科学 | 734篇 |
综合类 | 140篇 |
预防医学 | 323篇 |
眼科学 | 103篇 |
药学 | 498篇 |
中国医学 | 27篇 |
肿瘤学 | 656篇 |
出版年
2023年 | 27篇 |
2022年 | 21篇 |
2021年 | 128篇 |
2020年 | 100篇 |
2019年 | 176篇 |
2018年 | 184篇 |
2017年 | 124篇 |
2016年 | 144篇 |
2015年 | 189篇 |
2014年 | 216篇 |
2013年 | 332篇 |
2012年 | 372篇 |
2011年 | 381篇 |
2010年 | 260篇 |
2009年 | 207篇 |
2008年 | 290篇 |
2007年 | 386篇 |
2006年 | 265篇 |
2005年 | 283篇 |
2004年 | 250篇 |
2003年 | 215篇 |
2002年 | 209篇 |
2001年 | 188篇 |
2000年 | 154篇 |
1999年 | 154篇 |
1998年 | 62篇 |
1997年 | 65篇 |
1996年 | 53篇 |
1995年 | 35篇 |
1994年 | 35篇 |
1993年 | 44篇 |
1992年 | 91篇 |
1991年 | 98篇 |
1990年 | 62篇 |
1989年 | 64篇 |
1988年 | 56篇 |
1987年 | 52篇 |
1986年 | 46篇 |
1985年 | 50篇 |
1984年 | 41篇 |
1983年 | 24篇 |
1982年 | 21篇 |
1981年 | 15篇 |
1980年 | 15篇 |
1979年 | 13篇 |
1978年 | 18篇 |
1977年 | 14篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1969年 | 9篇 |
排序方式: 共有6312条查询结果,搜索用时 15 毫秒
1.
2.
3.
Prahlad V. Raninga Andy C. Lee Debottam Sinha Yu-Yin Shih Deepak Mittal Ashwini Makhale Amanda L. Bain Devathri Nanayakarra Kathryn F. Tonissen Murugan Kalimutho Kum Kum Khanna 《International journal of cancer. Journal international du cancer》2020,146(1):123-136
Triple-negative breast cancer (TNBCs) is a very aggressive and lethal form of breast cancer with no effective targeted therapy. Neoadjuvant chemotherapies and radiotherapy remains a mainstay of treatment with only 25–30% of TNBC patients responding. Thus, there is an unmet clinical need to develop novel therapeutic strategies for TNBCs. TNBC cells have increased intracellular oxidative stress and suppressed glutathione, a major antioxidant system, but still, are protected against higher oxidative stress. We screened a panel of antioxidant genes using the TCGA and METABRIC databases and found that expression of the thioredoxin pathway genes is significantly upregulated in TNBC patients compared to non-TNBC patients and is correlated with adverse survival outcomes. Treatment with auranofin (AF), an FDA-approved thioredoxin reductase inhibitor caused specific cell death and impaired the growth of TNBC cells grown as spheroids. Furthermore, AF treatment exerted a significant in vivo antitumor activity in multiple TNBC models including the syngeneic 4T1.2 model, MDA-MB-231 xenograft and patient-derived tumor xenograft by inhibiting thioredoxin redox activity. We, for the first time, showed that AF increased CD8+Ve T-cell tumor infiltration in vivo and upregulated immune checkpoint PD-L1 expression in an ERK1/2-MYC-dependent manner. Moreover, combination of AF with anti-PD-L1 antibody synergistically impaired the growth of 4T1.2 primary tumors. Our data provide a novel therapeutic strategy using AF in combination with anti-PD-L1 antibody that warrants further clinical investigation for TNBC patients. 相似文献
4.
5.
Thirty-nine primary surgical cases for correction of congenital aural atresia were reviewed for complications and long-term hearing results. Hearing averages of 25 dB for mild atresia, 40 dB for moderate atresia, and 46 dB for severe atresia were obtained. Serviceable hearing was achieved in 64% of the cases. The two most frequent complications were stenosis and recurrent infections of the cavity and canal skin, with an incidence of 33% and 31%, respectively. Use of split-thickness instead of full-thickness skin graft was associated with fewer complications. The goal of this review is also to share the experience of the senior author in the management of this complex problem. 相似文献
6.
Radionuclide brain scintigraphy and computed tomography (CT) demonstrated cerebral lesions in two patients with acquired immunodeficiency disease syndrome (AIDS) complicated by opportunistic infection of the brain. In the detection of these cerebral lesions, [99mTc]DTPA radionuclide scintigraphy was as reliable as CT. Since malignant lymphoma involving the brain has been seen with increasing frequency in patients with AIDS, the positive brain scan alone is nonspecific and should be correlated appropriately with the clinical setting. 相似文献
7.
8.
9.
10.