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排序方式: 共有112条查询结果,搜索用时 15 毫秒
1.
Mahnaz Fatahzadeh Lida Radfar David A Sirois 《Quintessence international, dental digest》2006,37(10):777-787
Dental management of patients with autoimmune vesiculobullous disorders is complicated because of prominent involvement of oral mucosa, increased risk of oral disease, and difficulty in rendering dental care. Although these diseases are relatively uncommon, dental practitioners should be familiar with the oral sequelae of these conditions and their management. Pemphigus vulgaris, cicatricial pemphigoid, and epidermolysis bullosa represent the most common autoimmune oral vesiculobullous diseases. This case-illustrated review summarizes the pathogenesis, diagnostic features, and natural history of oral vesiculobullous disorders, placing an emphasis on the treatment and prevention of associated oral disease aimed at maintaining a healthy, functional dentition. 相似文献
2.
Habib Sadeghirad Tayyeb Bahrami Sepideh M. Layeghi Hassan Yousefi Meysam Rezaei Seyed R. Hosseini-Fard Payar Radfar Majid E. Warkiani Ken O'Byrne Arutha Kulasinghe 《Immunology》2023,168(2):256-272
Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective for a subset of patients. To determine the best therapeutic approach, a thorough and in-depth profiling of the tumour microenvironment (TME) is required. The TME is a complex network of cell types that form an interconnected network, promoting tumour cell initiation, growth and dissemination. The stroma, immune cells and endothelial cells that comprise the TME generate a plethora of cytotoxic or cytoprotective signalling pathways. In this review, we discuss immunotherapeutic targets in NSCLC tumours and how the TME may influence patients' response to immunotherapy. 相似文献
3.
Objectives:To examine the relationship between palatally displaced maxillary canines (PDC) and the maxillary transverse dimension using cone-beam computed tomography (CBCT).Materials and Methods:Thirty-three patients (11 males and 22 females, mean age 18.2 years) with PDC were matched to 66 patients (22 males and 44 females, mean age 18.1 years) without PDC (control) by gender, age, and posterior occlusion. A CBCT image was taken on all the patients prior to any orthodontic treatment. For each patient the maxillary basal bone widths and interdental widths at the maxillary first molars and first and second premolars were measured on axial and coronal sections of CBCT images. In addition, the presence of permanent tooth agenesis and the widths of maxillary incisors were recorded.Results:Similar maxillary transverse dimensions, both skeletally and dentally, were found between the PDC and control groups. In the PDC group, the number of patients with permanent tooth agenesis was six times higher than in the control group. In addition, the maxillary lateral incisors on PDC-affected sides were smaller than those of control group (P < .05).Conclusions:The maxillary transverse dimension, both skeletally and dentally, had no effect on the occurrence of PDC. The higher prevalence of permanent tooth agenesis was found in the PDC group. Moreover, the mean mesiodistal width of maxillary lateral incisors in the PDC group was significantly smaller than in the control group (P < .05). 相似文献
4.
Keivan Adinehbeigi Mohammad Hossein Radfar Khatereh Rahmani Mohammad Mirzaei Dehaghi Masoud Sami Zeinab Yadegari 《Comparative clinical pathology》2013,22(3):461-466
A cross-sectional survey was carried out on goats slaughtered at the Kerman abattoir from September 2010 to September 2011 to determine the prevalence of cystic hydatidosis. Postmortem examination, hydatid cyst characterization were conducted. Out of the total of 2,002 animals examined (889 females and 1,113 males), 74 (3.69%) were found harboring one or more hydatid cyst. The result obtained from postmortem examination indicated that a total of 91 visceral organs were found harboring one or more hydatid cysts. The involvement of lung, liver, and muscles was found to be 43.95%, 42.85%, and 13.18% respectively. From the total of 575 cysts counted, 214 (37.21%), 186 (32.34%), 63 (10.95%), and 112 (19.47%) were small, medium, large, and calcified cysts, respectively, and 120 (20.86%) and 343 (59.65%) were fertile and sterile cysts, respectively. Out of the 120 fertile cysts subjected for viability test, 116 (96.66%) were viable. 相似文献
5.
Mohammad Mirzaei Dehaghi Mohsen Fallahi Masoud Sami Mohammad Hosein Radfar 《Comparative clinical pathology》2013,22(3):343-346
Sarcocystosis caused by different Sarcocystis species and is a zoonotic protozoan infection with worldwide distribution in man and many animal species. In the present study, three techniques — direct inspection, impression smears and digestion method — were used for the diagnosis of Sarcocystis infection in 112 slaughtered sheep in a Kerman abattoir from November 2010 to May 2011. A total of 450 slaughtered sheep were selected randomly during three seasons, and their oesophagus and diaphragm were inspected using naked eye examination. In the second stage, 112 carcasses out of the 450 which had no apparent infection were selected randomly and their meat investigated using two techniques: impression smear with staining and pepsin digestion. The percentage of macroscopic cysts found in the oesophagus and diaphragm muscle was 6% and 2.88%, respectively, and microscopically, infection was found in 100% of the organs. There was no significant difference between different ages or between males and females. Although all of the sheep were found to be infected with Sarcocystis, majority of the cysts were demonstrated microscopically. This suggests that meat should be cooked sufficiently, since a macroscopic inspection may not provide true results. 相似文献
6.
p19Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation 总被引:10,自引:0,他引:10 下载免费PDF全文
Arash Radfar Indira Unnikrishnan Han-Woong Lee Ronald A. DePinho Naomi Rosenberg 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(22):13194-13199
The Ink4a/Arf locus encodes p16Ink4a and p19Arf and is among the most frequently mutated tumor suppressor loci in human cancer. In mice, many of these effects appear to be mediated by interactions between p19Arf and the p53 tumor-suppressor protein. Because Tp53 mutations are a common feature of the multistep pre-B cell transformation process mediated by Abelson murine leukemia virus (Ab-MLV), we examined the possibility that proteins encoded by the Ink4a/Arf locus also play a role in Abelson virus transformation. Analyses of primary transformants revealed that both p16Ink4a and p19Arf are expressed in many of the cells as they emerge from the apoptotic crisis that characterizes the transformation process. Analyses of primary transformants from Ink4a/Arf null mice revealed that these cells bypassed crisis. Because expression of p19Arf but not p16 Ink4a induced apoptosis in Ab-MLV-transformed pre-B cells, p19Arf appears to be responsible for these events. Consistent with the link between p19Arf and p53, Ink4a/Arf expression correlates with or precedes the emergence of cells expressing mutant p53. These data demonstrate that p19Arf is an important part of the cellular defense mounted against transforming signals from the Abl oncoprotein and provide direct evidence that the p19Arf–p53 regulatory loop plays an important role in lymphoma induction. 相似文献
7.
Safoora Gholaminezhad Molouk Hadjibabaie Kheirollah Gholami Mohammad Reza Javadi Mania Radfar Iman Karimzadeh Ardeshir Ghavamzadeh 《Annals of hematology》2014,93(11):1913-1922
The aim of this study was to determine the pattern as well as associated factors of moderate and major potential drug-drug interactions (PDDIs) in both the pre- and early post-transplantation stages at a referral hematopoietic stem cell transplantation (HSCT) center. All adolescents and adults undergone HSCT within a 3-year period were screened retrospectively for potential moderate or severe PDDIs by the Lexi-Interact On-Desktop software. Among 384 patients, a total of 13,600 PDDIs were detected. The median (interquartile range) cumulative PDDIs burden was 41 (28). All (100 %) individuals experienced at least one PDDI. More than four fifths (81.8 %) of detected PDDIs were moderate. The predominant mechanism of PDDIs was pharmacokinetics (54.3 %). Interaction between sulfamethoxazole-trimethoprim and fluconazole was the most common PDDIs involving 95.3 % of the study population. More than three fifths (61.5 %) of detected PDDIs were caused by HSCT-related medications. No interaction was identified between two anticancer agents. Interactions of cyclophosphamide with phenytoin, busulfan with metronidazole, dexamethasone, or clarithromycin were the only detected PDDI between anticancer and non-anticancer medications. Type of HSCT and the numbers of administered medications were significantly associated with major PDDIs. The epidemiology, real clinical consequence, and economic burden of DDIs on patients undergone HSCT particularly around the transplantation period should be assessed further by prospective, multicenter studies. 相似文献
8.
Pregnancy and lactation 总被引:4,自引:0,他引:4
Suresh L Radfar L 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2004,97(6):672-682
Pregnancy results in physiologic changes in almost all organ systems in the body mediated mainly by female sex hormones. Physiologic changes of pregnancy influence the dental management of women during pregnancy. Understanding these normal changes is essential for providing quality care for pregnant women. This review article briefly discusses the cardiovascular, respiratory, gastrointestinal, urogenital, endocrine, and oral physiologic changes that occur during normal gestation. A summary of current scientific knowledge of ionizing radiation is presented. Information about the compatibility, complications, and excretion of the common drugs during pregnancy is provided. Drugs and their usage during breast-feeding are also discussed. Guidelines for the management of a pregnant patient in the dental office are summarized. 相似文献
9.
10.
Simforoosh N Aminsharifi A Tabibi A Noor-Alizadeh A Zand S Radfar MH Javaherforooshzadeh A 《BJU international》2008,101(10):1293-1296