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排序方式: 共有1319条查询结果,搜索用时 250 毫秒
1.
Manuel Steiner Andishe Attarbaschi Margit K nig Helmut Gadner Oskar A. Haas Georg Mann 《Pediatric hematology and oncology》2004,22(1):11-16
Constitutional trisomy 21 is the most prominent predisposing factor to childhood leukemia, whereas the t(12;21)(p13;q22) with its molecular genetic counterpart, the TEL/AML1 fusion gene, is the most common acquired chromosomal rearrangement in childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). Thus, it was somewhat surprising that according to the currently available literature the incidence of TEL/AML1+ BCP ALL is extremely low in patients with Down syndrome (DS). To further investigate this issue in a population-based fashion, the authors retrospectively assessed the number of DS patients with a TEL/AML1+ ALL in two consecutive Austrian ALL multicenter trials. Accordingly, they were able to analyze 8 of 10 individuals with DS and a BCP ALL, including 2 who suffered from a TEL/AML1+ leukemia. Based on this observation we concluded that individuals with a constitutional trisomy 21 may have the similar likelihood to develop a TEL/AML1+ leukemia as BCP ALL patients without this specific predisposing factor. 相似文献
2.
Results of Transplanting Developing Third Molars as Part of Orthodontic Space Management 总被引:2,自引:0,他引:2
Oskar Bauss Reza Sadat-Khonsari Werner Engelke Bärbel Kahl-Nieke 《Journal of orofacial orthopedics》2002,63(6):483-492
PATIENTS AND METHOD: The aim of the present study was to contribute to a more accurate indication and better integration of developing third molar transplantation into orthodontic space management, using the results gleaned from the authors' own pool of patients. For this purpose, a clinical and radiographic examination of 61 transplanted developing molars in 57 patients was carried out after an average of 3.3 years. RESULTS: The overall success rate was 85%. Failure was due in 10% of cases to impaired periodontal healing (inflammatory root resorption, ankylosis, or increased pocket probing depths) and in 5% of cases to insufficient or arrested postoperative root development accompanied by increased transplant mobility. The incidence of postoperative cessation of further root development was significantly higher (p = 0.011) in transplants at early developmental stages, which also had a negative impact on the final root length, the crown-root ratio and the mobility values of these transplants. CONCLUSIONS: The transplantation of developing third molars should be given stronger consideration in treatment plans for orthodontic space management although it represents a real alternative to orthodontic space closure only in exceptional cases. However, unlike implantological or prosthodontic treatment, it offers an opportunity to replace a missing or non-retainable tooth with a patient's own vital and fully functional tooth, provided the appropriate transplant is selected. 相似文献
3.
Mechanical function of intermediate filaments in arteries of different size examined using desmin deficient mice 总被引:2,自引:1,他引:1
Oskar Karlsson Wede Mia Löfgren Zhenlin Li† Denise Paulin† ers Arner 《The Journal of physiology》2002,540(3):941-949
Protein composition and mechanical function of intermediate filaments were examined in arteries of different sizes using desmin deficient mice (Des−/−) and their wild-type controls (Des+/+). Using SDS-PAGE gels and Western blots we found a gradient in desmin expression in the arterial tree; the desmin content increased from the elastic artery aorta, via the muscular mesenteric artery to the resistance-sized mesenteric microarteries ∼150 μm in diameter in Des+/+ mice. Mechanical experiments were performed on the aorta, the mesenteric artery and resistance-sized arteries using wire myographs. For aorta and mesenteric artery, no differences in passive or active circumference- stress relations were found between Des−/− and Des+/+ mice. In microarteries, both passive and active stress were lower in the Des−/− group. In conclusion, large elastic and muscular arteries contain a relatively low amount of desmin, and the desmin intermediate filaments do not seem to play a major role in the mechanical properties of these larger arterial vessels. In the microarteries, where expression of desmin is high, desmin plays a role in supporting both passive and active tension. 相似文献
4.
Oskar Thordarson 《Journal of molecular medicine (Berlin, Germany)》1941,20(22):572-574
Zusammenfassung Es wurden 112 Frauen in verschiedenen Stadien der Schwangerschaft untersucht und 25 Frauen in den ersten 4 Wochen nach der Geburt. Der Durchschnittswert der Prothrombinkonzentration steigt nach dem 3. Monat bedeutend an, diese Steigerung hält bis zum 6. Monat an, dann findet man bis zum Abschluß der Schwangerschaft konstante Prothrombinwerte. Bei 7 von 85 Frauen, die nach dem 3. Schwangerschaftsmonat untersucht wurden, wurden normale Prothrombinwerte festgestellt, bei allen anderen waren die gefundenen Werte absolut erhöht. Der höchste gefundene Wert war 310%. Die Prothrombinkonzentration fällt im Laufe von 1–3 Wochen nach der Geburt wieder zu normalen Werten ab.Die bei den verschiedenen Frauen stark variierende Hyperprothrombinämie ist bei Primiparen und Multiparen praktisch genommen gleich und ist unabhängig davon, ob die Frauen lange dauernde Molimina, Proteinurie oder Ödeme gehabt hatten. Es wurde kein Zusammenhang zwischen der Prothrombinkonzentration und dem Blutverlust bei der Geburt nachgewiesen. Von 57 der untersuchten Frauen liegen Angaben über den Verlauf der ganzen Schwangerschaft und Wochenbett vor; keine dieser Frauen hatten eine Thrombosie.Wieweit die Hyperprothrombinämie durch Irritation der Leber oder Hyperaktivität des Knochenmarks verursacht wird, ist nicht zu entscheiden.Es ist anzunehmen, daß die Hyperprothrombinämie der Grund für die erhöhte Koagulationsfähigkeit des Blutes von graviden Frauen ist, wie bereits von anderen nachgewiesen wurde. 相似文献
5.
Dr. med. et phil. Oskar Gros 《Naunyn-Schmiedeberg's archives of pharmacology》1913,71(5):364-372
Ohne ZusammenfassungMit 1 Kurve. 相似文献
6.
Abstract – The dental records made on presentation of 1367 consecutive patients (731 females and 636 males) for orthodontic treatment at a private orthodontic practice between 1998 and 2002 were examined for data relating to trauma to the permanent incisors. The results showed that 10.3% of these patients had suffered from dental trauma before the onset of orthodontic treatment. The highest prevalence of dental trauma was determined in the 11–15 years age group, corresponding to the dental developmental stage of the late mixed dentition. The most frequently affected teeth were the maxillary central incisors (79.6%), and the most common types of trauma were fracture of enamel–dentin without pulpal involvement (42.7%) and fracture of enamel (33.8%). Compared to patients with normal overjet and adequate lip coverage, the frequency of dental trauma was significantly higher in patients with increased overjet and adequate lip coverage ( P = 0.028) or with increased overjet and inadequate lip coverage ( P = 0.003). The results of the present study indicate that a significant percentage of candidates for orthodontic treatment, and especially those with increased overjet and inadequate lip coverage, suffer trauma to their permanent incisors before the onset of orthodontic treatment. It might also be concluded that preventive orthodontic treatment of such patients should be initiated and completed before the age of 11, i.e. in the early to middle mixed dentition. 相似文献
7.
Ohne Zusammenfassung 相似文献
8.
Oberarzt Dr. med. et phil. Georg Oskar Harnapp 《Journal of molecular medicine (Berlin, Germany)》1938,17(11):390-391
Ohne Zusammenfassung 相似文献
9.
10.
Oskar Meggeneder 《Zeitschrift fur Gesundheitswissenschaften》2007,15(2):101-107
In a small company, the whole company culture, including the management style, is dominated by the owner. The management culture
in small companies and above all the management style of the owner determine the chances of successfully introducing workplace
health promotion (WHP). For this reason a typology was developed that describes the management personalities who affect the
company culture in small enterprises. This provides a guide to the possible success of WHP in connection with the management
style. Although a summary of the management and corporate culture of small companies in a few categories cannot show the variety
of social reality, it can provide orientation. The typical categories of company social order (a mixture of ownership and
leadership) in small and medium-sized enterprises are given below. Furthermore, there is an assessment of what the chances
of realising workplace health promotion are in each type of company. Small and medium-sized companies (SME) have a number
of organisational characteristics which are just ideal for the introduction and implementation of workplace health promotion.
The work of the employer and employees is often the same. Information in the company is generally comprehensive and easily
available. The lack of information which employees often complain about in large companies is not a problem. There is a good
flow of communication. Small companies have a flat hierarchy that enables participation, the essential requirement for WHP.
There is a close social relationship between the company head and the workforce, although it must be said that this closeness
can be dangerous, particularly if it is misused as complete social control. The readiness to implement Workplace Health Promotion
(WHP) in SME and the degree of success depends largely on the personality of the company manager and the style of leadership.
Considering the importance of a manager’s personality for WHP in SME, modules and instruments to assist company owners and
managers in SME are to be developed. On behalf of and in co-operation with the Austrian Network for Workplace Health Promotion
several modules have been introduced to assist owners and managers of SMEs. 相似文献