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1.
Paul Richter Erich Ebstein M. Gildemeister Mendel Eisner Koenigsfeld Schnabel C. Prausnitz Dessecker Edens Friedberg Oppenheimer Neisser Deusch Königsfeld Simon Lichtenberg Gniesbach Koch Valentin Zinn J. Rothberger Lipschitz A. W. Fischer Nick Henning Frik Euler Holthusen Gaupp Lange Cohn 《Journal of molecular medicine (Berlin, Germany)》1922,1(14):697-703
Ohne Zusammenfassung 相似文献
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R. Böhm H. G. Klotz Ludwig Waelsch Richard Fischel Paul Neisser von Notthafft S. Prissmann L. Philippson Jacob Frédéric Ed. Oppenheimer Ludwig Waelsch Victor Bandler 《Archives of dermatological research》1902,63(2-3):425-453
Ohne Zusammenfassung 相似文献
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Bernh Fischer-Wasels Gottschalk Griesbach Peiper Koenigsfeld Herzfeld Oppenheimer Schübel Bernhardt Halberstaedter Mendel Dresel Finkenrath Ulrici Seligmann Eisner-Behrend W. Zinn Edens Jonas H. Hirschfeld A. W. Fischer Freudenberg Sperling Nonnenbruch G. Eisner Rosenberg Hübner O. Wiener Preuss Esch 《Journal of molecular medicine (Berlin, Germany)》1928,7(13):608-615
Ohne Zusammenfassung 相似文献
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Gerald M. Oppenheimer 《American journal of public health》1997,87(4):697-698
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The ability of thiols to reduce 3-azidothymidine (AZT) to 3-aminothymidine has been investigated. Incubation with glutathione, dithiothreitol (DTT), or mercaptoethanol at pH 7.2 and 37°C leads to quantitative reduction of the azido moiety to an amine. The reaction is first order in AZT and first order in reducing agent (mono- or dithiol). The second-order rate constants are 2.77 × 10–3, 6.55 × 10–5, and 6.35 × 10–6
M
–l sec–1 for the dithiothreitol, glutathione, and mercaptoethanol reductions, respectively. The thiol reduction of alkyl azide to amine under mild conditions is a synthetic method particularly suitable for water-soluble azido compounds that are sensitive to catalytic hydrogenation. The potential for the mono- or dithiol-mediated reduction of alkyl azides under biological conditions must be considered when conducting studies of azido drugs. 相似文献
8.
Daniel L. Hamilos MD John J. Oppenheimer MD Harold S. Nelson MD Sally Wenzel MD Sue Driscoll RN Richard F. Lockey MD David B. K. Golden MD Leland Fan MD Ralph J. Sanks RPh S. Allen Bock MD John W. Yunginger MD Donald Stevenson MD Timothy Sullivan MD Thomas Corbridge MD 《The Journal of allergy and clinical immunology》1993,91(6)
These guidelines are intended to reduce the potential for serious or life-threatening reactions when clinical research is conducted. The following issues were addressed: identifying the risks involved in the research, providing adequate safeguards in the protocol design and during withholding of medication, anticipating risks, minimizing the chances for human error, providing resuscitative equipment sufficient to deal with the most serious anticipated life-threatening reactions, planning for medical support in case of a life-threatening emergency, and optimizing the use of medical personnel and expertise to handle emergency situations. The guidelines also discuss important general issues about protocol design and implementation and the human subject consent form, which should facilitate the approval of protocols by the governing institutional review board.The guidelines are not meant to be inflexible or applicable to all research situations. However, it is our hope that they will allow for clinical research to be conducted in a manner that affords the research subjects a high degree of protection from unnecessary and possibly fatal injuries. 相似文献
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Age comparative content anaylses were carried out for eleven support-discussion groups. Comparisons of six groups of elderly persons and five groups of college youth revealed that the older more frequently discuss bodily changes, family relations, significant others and external sources of self respect. The young were more concerned with physical vulnerabilities. The elderly were more likely to discuss matters in terms of the past. The results are considered in the light of a life stage developmental conception of group behavior which could have implications for helping interventions. 相似文献