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ILAN HAMMEL OSNAT SHOR-HAZAN TORA ELDAR DINA AMIHAI SYLVIA LEW 《Journal of anatomy》1999,194(1):51-60
Secretory granule formation in pancreatic acinar cells is known to involve massive membrane flow. In previous studies we have undertaken morphometry of the regranulation mechanism in these cells and in mast cells as a model for cellular membrane movement. In our current work, electron micrographs of pancreatic acinar cells from ICR mice were taken at several time points after extensive degranulation induced by pilocarpine injection in order to investigate the volume changes of rough endoplasmic reticulum (RER), nucleus, mitochondria and autophagosomes. At 2–4 h after stimulation, when the pancreatic cells demonstrated a complete loss of granules, this was accompanied by an increased proportion of autophagosomal activity. This change primarily reflected a greatly increased proportion of profiles retaining autophagic vacuoles containing recognisable cytoplasmic structures such as mitochondria, granule profiles and fragments of RER. The mitochondrial structures reached a significant maximal size 4 h following injection (before degranulation 0.178±0.028 μm3 ; at 4 h peak value, 0.535±0.109 μm3 ). Nucleus size showed an early volume increase approaching a maximum value 2 h following degranulation. The regranulation span was thus divided into 3 stages. The first was the membrane remodelling stage (0–2 h). During this period the volume of the RER and secretory granules was greatly decreased. At the intermediate stage (2–4 h) a significant increase of the synthesis zone was observed within the nucleus. The volume of the mitochondria was increasing. At the last step, the major finding was a significant granule accumulation in parallel with an active Golgi zone. 相似文献
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STEFAN BOGDAN M.D. ROBERT KLEMPFNER M.D. AVI SABBAG M.D. DAVID LURIA M.D. OSNAT GUREVITZ M.D. DAVID BAR‐LEV M.D. IGOR LIPCHENCA M.D. EYAL NOF M.D. RAFAEL KUPERSTEIN M.D. ILAN GOLDENBERG M.D. MICHAEL ELDAR M.D. MICHAEL GLIKSON M.D. ROY BEINART M.D. 《Journal of cardiovascular electrophysiology》2014,25(11):1188-1195
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MAYA M. ZALKIND DMD OSNAT KEISAR DMD † PNINA EVER-HADANI BSc MPH ‡ RODIKA GRINBERG DMD § MICHAEL N. SELA DMD PHD # 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》1998,10(4):187-190
Abstract: The aim of the in vitro study was to examine the accumulation of Streptococcus mutans on light-cured composite materials and amalgam. Bacteria cultures were grown in a brain heart infusion medium, and their growth rate was determined through turbidity measurements. The data, so obtained, were evaluated statistically by analysis of variance (ANOVA) followed by Scheffe test. Experiments on amalgam showed better results compared to those on composite materials. There were no statistically significant differences in plaque accumulation on different composite materials after finishing and polishing procedures, compared to plaque accumulation on composite materials against a Mylar strip. 相似文献
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ROY BEINART M.D. ATHANASIOS MICHAILIDIS M.D. OSNAT T. GUREVITZ M.D. MICHAEL GLIKSON M.D. F.A.C.C. F.E.S.C. 《Pacing and clinical electrophysiology : PACE》2009,32(1):143-145
Mutations of the cardiac sodium channel gene, SCN5A, are present in both long-QT and Brugada syndromes. Flecainide is used as a provocative test to unmask the electrocardiogram (ECG) phenotype of the Brugada syndrome, as well as long-term treatment for long QT-3 syndrome, since it shortens the QT interval. We report a case where oral flecainide induced syncope with a Brugada ECG pattern in a patient with known long QT-3 syndrome. 相似文献
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