全文获取类型
收费全文 | 15152篇 |
免费 | 957篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 141篇 |
儿科学 | 411篇 |
妇产科学 | 313篇 |
基础医学 | 2646篇 |
口腔科学 | 533篇 |
临床医学 | 1376篇 |
内科学 | 2789篇 |
皮肤病学 | 352篇 |
神经病学 | 1422篇 |
特种医学 | 381篇 |
外国民族医学 | 2篇 |
外科学 | 1545篇 |
综合类 | 98篇 |
一般理论 | 6篇 |
预防医学 | 1283篇 |
眼科学 | 226篇 |
药学 | 1324篇 |
中国医学 | 21篇 |
肿瘤学 | 1288篇 |
出版年
2023年 | 77篇 |
2022年 | 62篇 |
2021年 | 400篇 |
2020年 | 276篇 |
2019年 | 300篇 |
2018年 | 392篇 |
2017年 | 312篇 |
2016年 | 395篇 |
2015年 | 398篇 |
2014年 | 486篇 |
2013年 | 725篇 |
2012年 | 997篇 |
2011年 | 985篇 |
2010年 | 551篇 |
2009年 | 525篇 |
2008年 | 807篇 |
2007年 | 850篇 |
2006年 | 860篇 |
2005年 | 777篇 |
2004年 | 750篇 |
2003年 | 687篇 |
2002年 | 674篇 |
2001年 | 292篇 |
2000年 | 294篇 |
1999年 | 266篇 |
1998年 | 127篇 |
1997年 | 158篇 |
1996年 | 119篇 |
1995年 | 116篇 |
1994年 | 100篇 |
1993年 | 91篇 |
1992年 | 185篇 |
1991年 | 188篇 |
1990年 | 158篇 |
1989年 | 154篇 |
1988年 | 159篇 |
1987年 | 128篇 |
1986年 | 129篇 |
1985年 | 96篇 |
1984年 | 116篇 |
1983年 | 78篇 |
1982年 | 67篇 |
1981年 | 58篇 |
1980年 | 53篇 |
1979年 | 61篇 |
1978年 | 75篇 |
1977年 | 55篇 |
1975年 | 74篇 |
1974年 | 68篇 |
1972年 | 54篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Monika Scheer Christian Vokuhl Iris Veit‐Friedrich Marc Münter Thekla von Kalle Michael Greulich Steffan Loff Sabine Stegmaier Monika Sparber‐Sauer Felix Niggli Ruth Ladenstein Bernarda Kazanowska Gustaf Ljungman Kirsi Jahnukainen Jrg Fuchs Stefan S. Bielack Ewa Koscielniak Thomas Klingebiel 《Pediatric blood & cancer》2020,67(2)
6.
7.
8.
Jenny U. Johansson Nathaniel S. Woodling Qian Wang Maharshi Panchal Xibin Liang Angel Trueba-Saiz Holden D. Brown Siddhita D. Mhatre Taylor Loui Katrin I. Andreasson 《The Journal of clinical investigation》2015,125(1):350-364
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer’s disease (AD), however, beneficial microglial functions become impaired, accelerating synaptic and neuronal loss. Better understanding of the molecular mechanisms that contribute to microglial dysfunction is an important objective for identifying potential strategies to delay progression to AD. The inflammatory cyclooxygenase/prostaglandin E2 (COX/PGE2) pathway has been implicated in preclinical AD development, both in human epidemiology studies and in transgenic rodent models of AD. Here, we evaluated murine models that recapitulate microglial responses to Aβ peptides and determined that microglia-specific deletion of the gene encoding the PGE2 receptor EP2 restores microglial chemotaxis and Aβ clearance, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signaling, and prevents synaptic injury and memory deficits. Our findings indicate that EP2 signaling suppresses beneficial microglia functions that falter during AD development and suggest that inhibition of the COX/PGE2/EP2 immune pathway has potential as a strategy to restore healthy microglial function and prevent progression to AD. 相似文献
9.
Peter D. Baade David C. Whiteman Monika Janda Anne E. Cust Rachel E. Neale Bernard Mark Smithers Adele C. Green Kiarash Khosrotehrani Victoria Mar H. Peter Soyer Joanne F. Aitken 《International journal of cancer. Journal international du cancer》2020,147(5):1391-1396
There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Australia) diagnosed with a single invasive melanoma (International Classification of Diseases for Oncology, third revision [ICD-O-3], C44, Morphology 872–879) between 1987 and 2011, including 11,883 diagnosed between 1987 and 1996, with up to 20 years follow-up (to December 2016). The 20-year case fatality increased by thickness, with the percentage of melanoma deaths within 20 years of diagnosis being up to 4.8% for melanomas with measured thickness <0.80 mm, 10.6% for tumors 0.8 to <1.0 mm and generally more than 30% for melanomas measuring 3 mm and more. For melanomas <1.0 mm, most deaths occurred between 5 and 20 years after diagnosis, whereas for thicker melanomas the reverse was true with most deaths occurring within the first 5 years. Five-year case fatality decreased over successive calendar time periods for melanomas <1.0 mm, but not for melanomas ≥1.0 mm. These findings demonstrate that the time course for fatal melanomas varies markedly according to tumor thickness at diagnosis. Improved understanding of the patient factors and characteristics of melanomas, in addition to tumor thickness, which increase the likelihood of progression, is needed to guide clinical diagnosis, communication with patients and ongoing surveillance pathways of patients with potentially fatal lesions. 相似文献
10.
H. Johansson M. Goto A. Siegbahn G. Elgue O. Korsgren B. Nilsson 《American journal of transplantation》2006,6(2):305-312
The instant blood-mediated inflammatory reaction (IBMIR) is triggered in clinical islet transplantation when human pancreatic islets come in contact with blood and may explain the initial tissue loss associated with this procedure. Low molecular weight dextran sulfate (LMW-DS; MM 5000), today available for clinical use, inhibits both complement and coagulation activation. In a tubing loop model, LMW-DS at concentrations ranging from 0.01 to 1 g/L showed a dose-dependent inhibition of IBMIR with an inhibition of coagulation and complement activation and less consumption of platelets and other blood cells. In blood or plasma APTT was demonstrated to be an excellent method for monitoring the LMW-DS concentration both in vitro and in vivo in a nonhuman primate model. The toxicity was assessed using a glucose challenge test and the pharmacokinetics was tested in the nonhuman primate model. Here, we present a tentative protocol for using LMW-DS in clinical islet transplantation. 相似文献