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排序方式: 共有327条查询结果,搜索用时 15 毫秒
1.
St?le Nordg?rd Gerhard Hein Brit Kari Stene Ketil Wichman Skj?stad Joachim T Maurer 《Otolaryngology--head and neck surgery》2007,136(5):818-822
OBJECTIVE: To evaluate long-term effectiveness of palatal implants for treatment of mild to moderate obstructive sleep apnea (OSA). STUDY DESIGN: A prospective study of 26 referred patients with a pretreatment apnea-hypopnea index (AHI) of 10 to 30 and a body mass index of < or =30, representing an extended follow-up of a subset of 41 patients enrolled in previous short-term trials. RESULTS: Twenty-one of 26 patients (80.8%) experienced a decrease in AHI. Fifteen of 26 patients (57.7%) had a follow-up AHI <10 at 1 year, whereas 13 patients (50%) had a 50% or greater reduction to an AHI <10 at 1 year. Mean AHI was reduced from 16.5 +/- 4.5 at baseline to 12.5 +/- 10.5 at 3 months (P < 0.014) and to 12.3 +/- 12.7 at 1 year (P < 0.019). CONCLUSIONS: Patients initially responding to palatal implants with improved AHI maintained improvement through long-term follow-up at 1 year. 相似文献
2.
Ketil Heimdal Ragnhild A. Lothe Sigrid Lystad Ruth Holm Sophie D. Foss Anne-Lise Brresen 《Genes, chromosomes & cancer》1993,6(2):92-97
Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using potymerase chain reaction (PCR), constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE), we have examined 32 patients with bilateral and familial germ cell tumors (GCT) and two patients with sporadic GCT for germline mutations within the conserved regions of the gene. In addition, 15 tumors were screened for somatic mutations and analyzed for loss of heterozygocity (LOH) at the TP53 locus. Twelve tumors were analyzed for expression of TP53 via immunohistochemistry. Neither germline nor somatic TP53 mutations were deteeted. LOH was observed in one of five informative cases. No tumors showed increased expression of TP53 protein. These results indicate that alterations in the TP53 gene are not important for the predisposition to and development of GCT. © 1993 Wiley-Liss, Inc. 相似文献
3.
Gottfried Greve Svein Rotevatn Ketil Grong Lodve Stangeland 《Virchows Archiv : an international journal of pathology》1988,413(3):205-213
Summary We have studied the histogenesis of malignant lymphoma (ML), small cleaved cell of the B-cell type and intermediate lymphocytic lymphoma (mantle zone lymphoma) by comparing immunophenotypes and ALP-activity of neoplastic cells with those of germinal center cells (follicular center cells) anti mantle zone (MZ) cells of secondary follicles in non-neoplastic lymphoid tissues. The neoplastic cells in 3 cases of ML, follicular, small cleaved cell and 1 case of ML, small cleaved cell expressed the phenotypes similar to those of germinal center (GC) B lymphocytes (SIgM+, B1+, B2+, CALLA+, SigD–, IL-2R–, Leu-1– and ALP–). The neoplastic cells in 2 cases of ML, follicular, small cleaved cell and 12 cases of ML, diffuse, small cleaved cell displayed the characteristic phenotypes of MZ B lymphocytes (SIgM+, SIgD+, BA-1+, IL-2R+, Leu-1+ and ALP+). The phenotypes of 2 cases of mantle zone lymphoma were closely comparable with those of MZ B lymphocytes. These findings indicate that the histogenesis of ML, small cleaved cell of the B-cell type is heterogeneous and can be divided phenotypically into 2 types (GC B lymphocyte origin and MZ B lymphocyte origin). It is also apparent that intermediate lymphocytic lymphoma (mantle zone lymphoma) is derived from MZ B lymphocytes of secondary follicles.This work was supported by a Grant-in-Aid for Cancer Research From the Ministry of Health and Welfare (NO. 61-2) 相似文献
4.
Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study Coordinators and Collaborators. The EU Biomed Collaborators 总被引:2,自引:0,他引:2 下载免费PDF全文
5.
Christiansen Anne Simone Juhl Mller Marie Louise Sletskov Kronborg Christian Haugan Ketil Jrgen Kber Lars Hjberg Sren Brandes Axel Graff Claus Diederichsen Sren Zga Nielsen Jonas Bille Krieger Derk Holst Anders Gaarsdal Svendsen Jesper Hastrup 《The European journal of health economics》2021,22(4):621-628
The European Journal of Health Economics - EQ-5D is a generic instrument to measure health-related quality of life. In 2009, a new version, EQ-5D-5L, was introduced as an attempt to reduce ceiling... 相似文献
6.
J. H. Heimdal H. J. Aarstad A. Aakvaag J. Olofsson 《European archives of oto-rhino-laryngology》1997,254(7):318-322
T-lymphocyte cell function was studied in vitro in peripheral blood mononuclear cells (PBMC) from 61 male patients with head
and neck squamous cell carcinomas compared to 46 control patients. Patients older than 80 years or with reduced tumor-related
performance status as measured by Karnofsky score less than 75 were excluded. In contrast to previous similar studies, control
subjects ensured a minimum stress load by sampling all patients on the day of either diagnostic or therapeutic surgery. PBMC
were separated by density-gradient centrifugation and subsequently cultured with autologous sera in vitro. The mitogen concanavalin
A (Con A), which stimulates all T-cell clones, was employed. Findings showed that increased Con A stimulation and PBMC proliferation
occurred with PBMC from cancer patients compared to that from control patients. In contrast, no differences could be detected
with respect to the stimulated supernatant level of interleukin-2, interleukin-4 or interferon-γ between the groups. These
results suggest that T-lymphocytes from PBMC are generally affected by neoplastic disease through either a supporting cell
or serum factor. 相似文献
7.
Christian Johann Lerche M.D. Ketil Jørgen Haugan M.D. Ph.D. Jesper Irving Reimers M.D. DMSc. Nikolaj Ihlemann M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(7):E188-E191
A 17‐year‐old male with a history of newly implanted mechanical valve at the aortic position, presented with fever, rigors, and painful cutaneous abscesses on his lower extremities and was suspected for infective endocarditis. Transthoracic echocardiography (TTE) showed a vegetation‐like structure following the movement of the mechanical heart valve (MHV), which eventually proved to be a product of degassing microbubbles (MB). 相似文献
8.
Flemming Javier Olsen Jesper Hastrup Svendsen Lars Køber Søren Højberg Ketil Haugan Jan Skov Jensen Tor Biering-Sørensen 《The international journal of cardiovascular imaging》2018,34(3):457-463
Speckle tracking echocardiography is an emerging technique, which is currently being included in clinical guidelines. We sought to investigate the impact of transducer frequency settings on speckle tracking derived measures. The study comprised of 22 subjects prospectively enrolled for a randomized controlled trial (LOOP-study, Clinicaltrials.gov:NCT02036450). Patients were above 70 years of age with increased risk of stroke, and had an echocardiogram performed, which included focused images of the left ventricle. Focused images were obtained with the transducer frequency set at both 1.7/3.3 and 1.5/3.0 MHz. The images were obtained immediately after each other at the exact same position for the two settings. Speckle tracking was performed in three apical projections, allowing for acquisition of layered global longitudinal strain (GLS) and strain rate measures. Concordance between the frequency settings was tested for endo-, mid-, and epicardial GLS and strain rates by coefficients of variation, bias coefficients and visually displayed by Bland–Altman plots. Bland–Altman plots did not reveal any significant over- or underestimation of any speckle tracking measure. Bias coefficients showed that none of the measurements differed significantly between the two settings (bias for GLSendo?=???0.07?±?2.94, p?=?0.91; GLSmid?=?0.02?±?2.70, p?=?0.98, GLSepi?=?0.07?±?2.53, p?=?0.90). Coefficients of variation were as follows: GLSendo?=?15.11%, GLSmid?=?15.28%, GLSepi?=?17.26%, systolic strain rate?=?15.66%, early diastolic strain rate?=?38.46%, late diastolic strain rate?=?11%. Changing between transducer frequency settings does not systematically derange speckle tracking measures. One can safely reduce the transducer frequency without compromising the validity of speckle tracking derived measures. 相似文献
9.
Izak J. Bisschoff Christine Zeschnigk Denise Horn Brigitte Wellek Angelika Rieß Maja Wessels Patrick Willems Peter Jensen Andreas Busche Jens Bekkebraten Maya Chopra Hanne Dahlgaard Hove Christina Evers Ketil Heimdal Ann‐Sophie Kaiser Erdmut Kunstmann Kristina Lagerstedt Robinson Maja Linné Patricia Martin James McGrath Winnie Pradel Katrina E. Prescott Bernd Roesler Gorazd Rudolf Ulrike Siebers‐Renelt Nataliya Tyshchenko Dagmar Wieczorek Gerhard Wolff William B. Dobyns Deborah J. Morris‐Rosendahl 《Human mutation》2013,34(1):237-247
OFD1, now recognized as a ciliopathy, is characterized by malformations of the face, oral cavity and digits, and is transmitted as an X‐linked condition with lethality in males. Mutations in OFD1 also cause X‐linked Joubert syndrome (JBTS10) and Simpson–Golabi–Behmel syndrome type 2 (SGBS2). We have studied 55 sporadic and six familial cases of suspected OFD1. Comprehensive mutation analysis in OFD1 revealed mutations in 37 female patients from 30 families; 22 mutations have not been previously described including two heterozygous deletions spanning OFD1 and neighbouring genes. Analysis of clinical findings in patients with mutations revealed that oral features are the most reliable diagnostic criteria. A first, detailed evaluation of brain MRIs from seven patients with cognitive defects illustrated extensive variability with the complete brain phenotype consisting of complete agenesis of the corpus callosum, large single or multiple interhemispheric cysts, striking cortical infolding of gyri, ventriculomegaly, mild molar tooth malformation and moderate to severe cerebellar vermis hypoplasia. Although the OFD1 gene apparently escapes X‐inactivation, skewed inactivation was observed in seven of 14 patients. The direction of skewing did not correlate with disease severity, reinforcing the hypothesis that additional factors contribute to the extensive intrafamilial variability. 相似文献
10.