排序方式: 共有38条查询结果,搜索用时 15 毫秒
1.
Kashani Bahareh Zandi Zahra Bashash Davood Zaghal Azam Momeny Majid Poursani Ensieh M. Pourbagheri-Sigaroodi Atieh Mousavi Seyed A. Ghaffari Seyed H. 《Cancer chemotherapy and pharmacology》2020,85(1):47-59
Cancer Chemotherapy and Pharmacology - Despite all advances in the treatment of ovarian cancer (OC), it remains the most lethal gynecological malignancy worldwide. There are growing amounts of... 相似文献
2.
Ensieh Nasli‐Esfahani Maryam Mohammadi‐Khanaposhtani Sepideh Rezaei Yaghoub Sarrafi Zeinab Sharafi Nasser Samadi Mohammad Ali Faramarzi Fatemeh Bandarian Haleh Hamedifar Bagher Larijani Mirhamed Hajimiri Mohammad Mahdavi 《Archiv der Pharmazie》2019,352(8)
A series of new Schiff bases bearing 1,2,3‐triazole 12a ? o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α‐glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α‐glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α‐glucosidase. 相似文献
3.
Xinjun Li Ensieh Memarian Jan Sundquist Bengt Z?ller Kristina Sundquist 《Obesity facts》2014,7(4):253-263
ObjectivesTo examine whether there is an association between neighbourhood deprivation and diagnosed childhood obesity, after accounting for family- and individual-level socio-demographic characteristics.MethodsAn open cohort of all children aged 0-14 years was followed between January 1, 2000 and December 31, 2010. Childhood residential locations were geocoded and classified according to neighbourhood deprivation. Data were analysed by multilevel logistic regression, with family- and individual-level characteristics at the first level and level of neighbourhood deprivation at the second level.ResultsDuring the study period, among a total of 948,062 children, 10,799 were diagnosed with childhood obesity. Age-adjusted cumulative incidence for diagnosed childhood obesity increased with increasing level of neighbourhood deprivation. Incidence of diagnosed childhood obesity increased with increasing neighbourhood-level deprivation across all family and individual-level socio-demographic categories. The odds ratio (OR) for diagnosed childhood obesity for those living in high-deprivation neighbourhoods versus those living in low-deprivation neighbourhoods was 2.44 (95% confidence interval (CI) = 2.22-2.68). High neighbourhood deprivation remained significantly associated with higher odds of diagnosed childhood obesity after adjustment for family- and individual-level socio-demographic characteristics (OR = 1.70, 95% CI = 1.55-1.89). Age, middle level family income, maternal marital status, low level education, living in large cities, advanced paternal and maternal age, family history of obesity, parental history of diabetes, chronic obstructive pulmonary disease, alcoholism and personal history of diabetes were all associated with higher odds of diagnosed childhood obesity.ConclusionsOur results suggest that neighbourhood characteristics affect the odds of diagnosed childhood obesity independently of family- and individual-level socio-demographic characteristics.Key Words: Childhood obesity, Neighbourhood-level deprivation, Incidence, Socio-demographic factors, Multilevel modelling 相似文献
4.
Larijani B Esfahani EN Amini P Nikbin B Alimoghaddam K Amiri S Malekzadeh R Yazdi NM Ghodsi M Dowlati Y Sahraian MA Ghavamzadeh A 《Acta medica Iranica》2012,50(2):79-96
Stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. Stem cells are divided into two categories of embryonic and adult. In another categorization stem cells are divided to Totipotent, Multipotent and Unipotent cells.So far usage of stem cells in treatment of various blood diseases has been studied (such as lymphoblastic leukemia, myeloid leukemia, thalassemia, multiple myeloma and cycle cell anemia). In this paper the goal is evaluation of cell therapy in treatment of Parkinson's disease, Amyotrophic lateral sclerosis, Alzheimer, Stroke, Spinal Cord Injury, Multiple Sclerosis, Radiation Induced Intestinal Injury, Inflammatory Bowel Disease, Liver Disease, Duchenne Muscular Dystrophy, Diabetes, Heart Disease, Bone Disease, Renal Disease, Chronic Wounds, Graft-Versus-Host Disease, Sepsis and Respiratory diseases. It should be mentioned that some disease that are the target of cell therapy are discussed in this article. 相似文献
5.
Khazaei M Fallahzadeh AR Sharifi MR Afsharmoghaddam N Javanmard SH Salehi E 《Clinics (S?o Paulo, Brazil)》2011,66(8):1419-1424
INTRODUCTION:
Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors.METHODS:
Twelve male rats were divided into two groups: control and diabetic (n = 6 each). Diabetes was induced with a single dose of streptozotocin (50 mg/kg). After 21 days, capillary density in the myocardial tissue was evaluated using immunohistochemical staining and is reported as capillaries per mm2. Blood samples were collected before and after the induction of diabetes.RESULTS:
In the diabetic group, serum nitric oxide and soluble vascular endothelial growth factor receptor 2 concentrations were lower than the levels in the control group, while the level of soluble vascular endothelial growth factor receptor 1 was significantly higher. There was no significant change in the serum vascular endothelial growth factor concentration between the diabetic and control groups; however, the ratio of vascular endothelial growth factor to vascular endothelial growth factor receptor 1 was significantly lower in the diabetic animals. The myocardial capillary density was also lower in the diabetic group compared with the control group (1549±161 vs. 2156±202/mm2, respectively).CONCLUSION:
Reduced serum nitric oxide and vascular endothelial growth factor receptor 2 levels, increased serum vascular endothelial growth factor receptor 1 levels and a lower vascular endothelial growth factor to vascular endothelial growth factor receptor 1 ratio may be responsible for the decreased myocardial capillary density in diabetic rats. 相似文献6.
Tehraninejad ES Hafezi M Arabipoor A Aziminekoo E Chehrazi M Bahmanabadi A 《Journal of assisted reproduction and genetics》2012,29(3):259-264
Purpose
To compare the efficacy of cabergoline (Cb2) and intravenous human albumin (HA) in the prevention of ovarian hyperstimulation syndrome. 相似文献7.
Ensieh Shahrokh Tehraninejad Roya Nasiri Batool Rashidi Fedieh Haghollahi Marzieh Ataie 《Archives of gynecology and obstetrics》2010,282(3):319-325
Purpose
To evaluate the efficacy of GnRH antagonist in comparison with the GnRH agonist protocol in OCP pretreated polycystic ovary syndrome (PCOs) patients undergoing their first ART cycle. 相似文献8.
Nahid Mashkouri Najafi Shahram Shahparvizi Hasan Rafati Ensieh Ghasemi Reza Alizadeh 《Journal of pharmaceutical and biomedical analysis》2010
Platinum compounds, including cis-dichlorodiaminoplatinum(II) or cisplatin, are an important class of anti-cancer drugs, which should be carefully monitored in the biological fluids. In this study, electrodeposition coupled with electrothermal atomic absorption spectrometry (ETAAS) was used for determination of Pt concentration in the human serum samples. The chemometric techniques were also used to verify the probable interactions among the important and effective parameters in the atomization process. Using response surfaces obtained by two factorial design techniques, the experimental design was applied for three effective parameters namely ashing temperature, atomizing temperature and modifier concentration as effective parameters on the atomization of Pt. The in situ digestions of serum samples, as well as the separation of the ultra-traces of Pt from concomitant in these samples were performed by using the in situ electrodeposition (ED) technique prior to the measurement by ETAAS. Six plasma samples of a patient who was administered parenteral cisplatin were analyzed using the proposed ED–ETAAS technique. The results showed the pharmacokinetic parameters of cisplatin in serum in accordance to the well-established data. A relatively good reproducibility %RSD = 2.44, low limit of detection LOD = 2.54 μg/L and promising characteristic mass mo = 91.30 pg were obtained using this technique. 相似文献
9.
Masoumeh Rasouli Seyed Abbas Mousavi Ahmad Khosravi Afsaneh Keramat Ensieh Fooladi 《Journal of psychosomatic obstetrics and gynaecology》2018,39(3):237-245
Objective: To examine the effectiveness of motivational interviewing (MI) on the stages of behavior change among nulliparous pregnant women who were preparing for childbirth.Methods: In this randomized clinical trial, 234 pregnant women were studied in two intervention groups (MI and lecture), and one control group at three stages. In weeks 16–19 of pregnancy, two counseling sessions were held for the MI group, and one lecturing session was held for the lecture group. In weeks 21 and 37 of pregnancy, the three groups were reevaluated.Results: At baseline, more than 70% of women were at pre-contemplation and contemplation stages. In week 21 of pregnancy, in MI 71% were at preparation stage, whereas in the lecture and control groups, 51.9% and 49.4% were at the contemplation stage, respectively. In week 37 of pregnancy, in MI, lecture and control groups, 90%, 59.7% and 27.3% were at the action stage, respectively (p?.001). The result of generalized estimating equation (GEE) analysis using a Poisson model indicated that the incident rate for lecture group was 1.7 (95% CI: 1.2–2.5) times the incident rate for the MI group. Also, the incident rate for control group was 3.4 (95% CI: 2.2–5.0) times the incident rate for the MI group.Conclusions: Motivational interviewing was effective in guiding nulliparous mothers toward positive behavior stages. 相似文献
10.
Maryam Peimani Gholamreza Garmaroudi Anita L. Stewart MirSaeed Yekaninejad Elham Shakibazadeh Ensieh Nasli-Esfahani 《Patient education and counseling》2021,104(7):1659-1667
ObjectiveTo investigate how patient-physician interpersonal processes of care are related to levels of diabetes-related distress, diabetes medication-taking behavior, and HbA1c during conversations with patients about intensifying medication.MethodsWe randomly recruited 1270 patients from diabetes specialty clinics in Tehran, Iran who were taking an additional oral diabetes medication or starting insulin during the prior 3 months. This interviewer-administered cross-sectional survey assessed multiple aspects of patient-physician interpersonal processes, diabetes-related distress, and diabetes medication-taking. Clinical history and HbA1c were collected from electronic medical records. Regression estimates and Structural Equation Modeling were used to test associations.ResultsSome communication scales indicated a significant relationship with total diabetes distress (P < 0.001). Diabetes medication-taking was associated with less diabetes distress (adjusted odds ratio [aOR]=0.45, P < 0.001), lower Hurried Communication (aOR=0.72, P = 0.013), higher Elicited Concerns (aOR=1.30, P = 0.012), and higher Explained Results (aOR=1.41, P < 0.001) scores. SEM analyses showed medication-taking behavior was associated with a 0.68 decrease in HbA1c. Hurried Communication and diabetes distress were directly associated with HbA1c.ConclusionAspects of patient-physician interpersonal processes at the time of intensifying diabetes treatment may be related to experiencing less distress, effective medication-taking, and improved HbA1c.Practice implicationsThe results are intended to inform communication strategies that physicians might incorporate into practice. 相似文献