全文获取类型
收费全文 | 354篇 |
免费 | 22篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 15篇 |
妇产科学 | 14篇 |
基础医学 | 33篇 |
口腔科学 | 1篇 |
临床医学 | 13篇 |
内科学 | 83篇 |
皮肤病学 | 4篇 |
神经病学 | 96篇 |
特种医学 | 10篇 |
外科学 | 23篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 37篇 |
眼科学 | 10篇 |
药学 | 16篇 |
肿瘤学 | 20篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 10篇 |
2019年 | 16篇 |
2018年 | 15篇 |
2017年 | 8篇 |
2016年 | 9篇 |
2015年 | 12篇 |
2014年 | 18篇 |
2013年 | 15篇 |
2012年 | 32篇 |
2011年 | 28篇 |
2010年 | 17篇 |
2009年 | 16篇 |
2008年 | 26篇 |
2007年 | 27篇 |
2006年 | 20篇 |
2005年 | 28篇 |
2004年 | 13篇 |
2003年 | 13篇 |
2002年 | 10篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1989年 | 4篇 |
1987年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有378条查询结果,搜索用时 62 毫秒
1.
Rats undergoing extinction of lever-pressing for food after the attenuation of an external feedback for this behavior exhibit excessive lever-pressing unaccompanied by an attempt to collect a reward. This behavior may be analogous to the excessive and unreasonable behavior seen in obsessive-compulsive disorder. In the present study, we tested the hypothesis that the compulsive behavior induced by signal attenuation is mediated via D(1) rather than D(2) receptors. Administration of 0.005, 0.01 and 0.03 mg/kg of the D(1) antagonist SCH 23390 reduced the number of compulsive lever-presses without affecting the number of lever-presses followed by an attempt to collect a reward. In contrast, administration of 0.005, 0.01, 0.024, 0.036 and 0.05 of the D(2) antagonist haloperidol dose-dependently decreased both types of lever-presses. In addition, haloperidol at doses that decreased lever-pressing in the post-training signal attenuation procedure (0.036 and 0.05 mg/kg) had a similar effect in regular extinction, whereas an SCH 23390 dose that decreased compulsive lever-pressing in the post-training signal attenuation procedure (0.01 mg/kg) had no effect on regular extinction. On the basis of electrophysiological data on the response of dopamine neurons to the omission of an expected reward, these results were interpreted as suggesting that compulsive lever-pressing depends on a phasic decrease in the stimulation of D(1) receptors. The implications of these results for the pathophysiology and treatment of obsessive-compulsive disorder are discussed. 相似文献
2.
Daphna Oyserman PhD Rami Benbenishty PhD Dalia Ben-Rabi MSW 《Child psychiatry and human development》1992,22(3):199-211
This study provides an overview of children, their families, and their circumstances at the time that the child entered foster care in Israel. Data regarding a representative sample of 800 children were collected as part of the ongoing operation of a clinical information system set up for Israel's foster care service in 1988. Implications of our findings for interventions are discussed. 相似文献
3.
Daphna Mezad Mordechai Hallak Mahmoud Huleihel Limor Gortzak-Uzan Ana Smolin Moshe Mazor 《Magnesium research》2002,15(3-4):247-252
Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations. Thirty-six patients at 24-34 weeks of singleton gestation, who presented with contractions (> or = 8 in 60 min) had amniocentesis to rule out intrauterine infection. The patients received intravenous MgSO4 for tocolysis. Twenty-six patients had amniocentesis performed before initiation of MgSO4 (controls) while 10 others had the procedure during tocolytic therapy (study patients). Magnesium, IL-1beta, IL-6, TNFalpha and IL-10 concentrations were measured. Study and control groups were statistically compared using Student t test. Mean magnesium levels were significantly higher in the study group (P < 0.01). There were no significant differences between the cytokines levels in maternal serum and in amniotic fluid between the groups. Our results suggest that the mechanism of magnesium as a tocolytic agent may not be mediated via the examined cytokines. 相似文献
4.
Marjorie C. Feinson Yaacov Lerner Daphna Levinson & Miriam Popper 《The Milbank quarterly》1997,75(2):235-260
Untested assumptions concerning ambulatory treatment have shaped mental health policies for decades. Three opinions prevail: (1) all use is alike; (2) any use leads to high use; and (3) all high use is discretionary and therefore excessive. These assumptions were tested, using data from a nationwide survey of ambulatory utilizers in Israel, a country that has universal coverage. The findings, based on detailed clinical and treatment records, challenge all three assumptions. Moreover, they document a diversity of clinical needs while also verifying substantial variations in the type, frequency, and duration of treatment provided to meet those needs. In brief, Israeli data do not confirm continuing concerns by policy makers about uncontrollable use of services with expanded mental health coverage. Special policy limitations on mental health treatment should be reconsidered in light of empirical evidence from a system without the restrictions that exist in the United States. 相似文献
5.
Viviane Kovess‐Masfety Jordi Alonso Matthias Angermeyer Evelyn Bromet Giovanni de Girolamo Peter de Jonge Koen Demyttenaere Silvia E. Florescu Michael J. Gruber Oye Gureje Chiyi Hu Yueqin Huang Elie G. Karam Robert Jin Jean‐Pierre Lpine Daphna Levinson Katie A. McLaughlin María E. Medina‐Mora Siobhan O'Neill Yutaka Ono Jos A. Posada‐Villa Nancy A. Sampson Kate M. Scott Victoria Shahly Dan J. Stein Maria C. Viana Zahari Zarkov Ronald C. Kessler 《Depression and anxiety》2013,30(4):395-406
6.
7.
Joost J F P Luiken Iman Momken Daphna D J Habets Mohammed El Hasnaoui Will A Coumans Debby P Y Koonen Jan F C Glatz Arend Bonen 《Endocrinology》2006,147(11):5205-5216
The protein thiol-modifying agent arsenite, a potent activator of stress signaling, was used to examine the involvement of MAPKs in the regulation of cardiac substrate uptake. Arsenite strongly induced p38 MAPK phosphorylation in isolated rat cardiac myocytes but also moderately enhanced phosphorylation of p42/44 ERK and p70 S6K. At the level of cardiomyocytic substrate use, arsenite enhanced glucose uptake dose dependently up to 5.1-fold but failed to stimulate long-chain fatty acid uptake. At the substrate transporter level, arsenite stimulated the translocation of GLUT4 to the sarcolemma but failed to recruit CD36 or FABPpm. Because arsenite did not influence the intrinsic activity of glucose transporters, GLUT4 translocation is entirely responsible for the selective increase in glucose uptake by arsenite. Moreover, the nonadditivity of arsenite-induced glucose uptake and insulin-induced glucose uptake indicates that arsenite recruits GLUT4 from insulin-responsive intracellular stores. Inhibitor studies with SB203580/SB202190, PD98059, and rapamycin indicate that activation of p38 MAPK, p42/44 ERK, and p70 S6K, respectively, are not involved in arsenite-induced glucose uptake. In addition, all these kinases do not play a role in regulation of cardiac glucose and long-chain fatty acid uptake by insulin. Hence, arsenite's selective stimulation of glucose uptake appears unrelated to its signaling actions, suggesting that arsenite acts via thiol modification of a putative intracellular protein target of arsenite within insulin-responsive GLUT4-containing stores. Because of arsenite's selective stimulation of cardiac glucose uptake, identification of this putative target of arsenite within the GLUT4-storage compartment may indicate whether it is a target for future strategies in prevention of diabetic cardiomyopathy. 相似文献
8.
9.
Mohammad M. Rahman Simona Rosu Daphna Joseph-Strauss Orna Cohen-Fix 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(7):2602-2607
The cell cycle is a highly regulated process that enables the accurate transmission of chromosomes to daughter cells. Here we uncover a previously unknown link between the tricarboxylic acid (TCA) cycle and cell cycle progression in the Caenorhabditis elegans early embryo. We found that down-regulation of TCA cycle components, including citrate synthase, malate dehydrogenase, and aconitase, resulted in a one-cell stage arrest before entry into mitosis: pronuclear meeting occurred normally, but nuclear envelope breakdown, centrosome separation, and chromosome condensation did not take place. Mitotic entry is controlled by the cyclin B–cyclin-dependent kinase 1 (Cdk1) complex, and the inhibitory phosphorylation of Cdk1 must be removed in order for the complex to be active. We found that following down-regulation of the TCA cycle, cyclin B levels were normal but CDK-1 remained inhibitory-phosphorylated in one-cell stage-arrested embryos, indicative of a G2-like arrest. Moreover, this was not due to an indirect effect caused by checkpoint activation by DNA damage or replication defects. These observations suggest that CDK-1 activation in the C. elegans one-cell embryo is sensitive to the metabolic state of the cell, and that down-regulation of the TCA cycle prevents the removal of CDK-1 inhibitory phosphorylation. The TCA cycle was previously shown to be necessary for the development of the early embryo in mammals, but the molecular processes affected were not known. Our study demonstrates a link between the TCA cycle and a specific cell cycle transition in the one-cell stage embryo.The developmental program of any organism must be precisely executed. In Caenorhabditis elegans embryos, immediately after fertilization, two pronuclei form at opposite poles of the embryo: one containing the maternal chromosomes and the other containing the paternal ones (1, 2). These pronuclei then move toward each other, and at the same time centrosomes separate and begin to assemble a spindle. After pronuclear meeting, the cell enters its first mitosis, resulting in nuclear envelope breakdown, chromatin condensation, and the subsequent alignment of chromosomes on the metaphase plate, followed by chromosome segregation (2). Entry into mitosis depends on the mitotic cyclin B–cyclin-dependent kinase 1 (Cdk1) complex. The activity of this complex is regulated by both cyclin B levels and regulatory phosphorylation of Cdk1. In particular, Cdk1 activity is inhibited by Wee1 phosphorylation, which is removed at the onset of mitosis by the Cdc25 phosphatase (3, 4). Cdk1 activation is also subjected to various checkpoints that inhibit mitotic progression in the presence of intracellular damage (5). However, in organisms that undergo rapid embryonic divisions, including C. elegans, checkpoints are inoperative during the first few cell cycles (6).Although it is clear that cell cycle progression requires energy, the link, if any, between metabolic pathways and progression through mitosis is poorly understood. Genes and proteins involved in various aspects of metabolism (e.g., nucleotide biosynthesis and lipid metabolism) are regulated by the cell cycle machinery, and cells will not commit to a new cell cycle if nutrients are scarce (7). However, to what extent the metabolic state of the cell is sensed by the cell cycle machinery once cells have passed into S phase is not clear (8).We have previously conducted a visual screen in C. elegans embryos for genes that when down-regulated by RNAi lead to an abnormal nuclear morphology (9). Most genes whose inactivation affected early embryonic development did so without arresting cell cycle progression. It was therefore striking when we came across a set of genes, coding for enzymes of the tricarboxylic acid (TCA) cycle, that when down-regulated, led to a one-cell stage arrest with paired nuclei. The TCA cycle, also known as the Krebs cycle, uses the oxidation of acetate (in the form of acetyl CoA) derived from carbohydrates, proteins, or lipids, to generate intermediates (i.e., NADH and FADH2) that are used by the electron transport chain for ATP production. Intermediates of the TCA cycle are also important for various anabolic pathways, such as fatty acid synthesis, and the synthesis of nucleotides. In this study, we examine the relationship between TCA cycle down-regulation and cell cycle progression in the one-cell C. elegans embryo. Our data suggest that down-regulation of the TCA cycle leads to a G2-like arrest at the one-cell stage embryo by preventing the activation of cyclin B–Cdk1. 相似文献
10.
Dan J. Stein Sergio Aguilar-Gaxiola Jordi Alonso Ronny Bruffaerts Peter de Jonge Zharoui Liu Jose Miguel Caldas-de-Almeida Siobhan O’Neill Maria Carmen Viana Ali Obaid Al-Hamzawi Mattias C. Angermeyer Corina Benjet Ron de Graaf Finola Ferry Viviane Kovess-Masfety Daphna Levinson Giovanni de Girolamo Silvia Florescu Chiyi Hu Norito Kawakami Josep Maria Haro Marina Piazza Jose Posada-Villa Bogdan J. Wojtyniak Miguel Xavier Carmen C.W. Lim Ronald C. Kessler Kate M. Scott 《General hospital psychiatry》2014