全文获取类型
收费全文 | 2403篇 |
免费 | 353篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 71篇 |
妇产科学 | 32篇 |
基础医学 | 377篇 |
口腔科学 | 133篇 |
临床医学 | 172篇 |
内科学 | 708篇 |
皮肤病学 | 40篇 |
神经病学 | 181篇 |
特种医学 | 131篇 |
外科学 | 349篇 |
综合类 | 82篇 |
预防医学 | 199篇 |
眼科学 | 12篇 |
药学 | 134篇 |
中国医学 | 1篇 |
肿瘤学 | 134篇 |
出版年
2021年 | 34篇 |
2020年 | 25篇 |
2019年 | 30篇 |
2018年 | 41篇 |
2017年 | 27篇 |
2016年 | 40篇 |
2015年 | 61篇 |
2014年 | 60篇 |
2013年 | 103篇 |
2012年 | 113篇 |
2011年 | 124篇 |
2010年 | 89篇 |
2009年 | 86篇 |
2008年 | 95篇 |
2007年 | 107篇 |
2006年 | 103篇 |
2005年 | 85篇 |
2004年 | 85篇 |
2003年 | 99篇 |
2002年 | 58篇 |
2001年 | 61篇 |
2000年 | 66篇 |
1999年 | 89篇 |
1998年 | 55篇 |
1997年 | 49篇 |
1996年 | 41篇 |
1995年 | 37篇 |
1994年 | 33篇 |
1993年 | 38篇 |
1992年 | 48篇 |
1991年 | 45篇 |
1990年 | 39篇 |
1989年 | 50篇 |
1988年 | 56篇 |
1987年 | 39篇 |
1986年 | 48篇 |
1985年 | 40篇 |
1984年 | 32篇 |
1983年 | 33篇 |
1982年 | 22篇 |
1981年 | 23篇 |
1980年 | 31篇 |
1979年 | 33篇 |
1978年 | 29篇 |
1977年 | 20篇 |
1976年 | 30篇 |
1975年 | 19篇 |
1974年 | 26篇 |
1973年 | 21篇 |
1972年 | 19篇 |
排序方式: 共有2767条查询结果,搜索用时 14 毫秒
1.
Prahlad V. Raninga Andy C. Lee Debottam Sinha Yu-Yin Shih Deepak Mittal Ashwini Makhale Amanda L. Bain Devathri Nanayakarra Kathryn F. Tonissen Murugan Kalimutho Kum Kum Khanna 《International journal of cancer. Journal international du cancer》2020,146(1):123-136
Triple-negative breast cancer (TNBCs) is a very aggressive and lethal form of breast cancer with no effective targeted therapy. Neoadjuvant chemotherapies and radiotherapy remains a mainstay of treatment with only 25–30% of TNBC patients responding. Thus, there is an unmet clinical need to develop novel therapeutic strategies for TNBCs. TNBC cells have increased intracellular oxidative stress and suppressed glutathione, a major antioxidant system, but still, are protected against higher oxidative stress. We screened a panel of antioxidant genes using the TCGA and METABRIC databases and found that expression of the thioredoxin pathway genes is significantly upregulated in TNBC patients compared to non-TNBC patients and is correlated with adverse survival outcomes. Treatment with auranofin (AF), an FDA-approved thioredoxin reductase inhibitor caused specific cell death and impaired the growth of TNBC cells grown as spheroids. Furthermore, AF treatment exerted a significant in vivo antitumor activity in multiple TNBC models including the syngeneic 4T1.2 model, MDA-MB-231 xenograft and patient-derived tumor xenograft by inhibiting thioredoxin redox activity. We, for the first time, showed that AF increased CD8+Ve T-cell tumor infiltration in vivo and upregulated immune checkpoint PD-L1 expression in an ERK1/2-MYC-dependent manner. Moreover, combination of AF with anti-PD-L1 antibody synergistically impaired the growth of 4T1.2 primary tumors. Our data provide a novel therapeutic strategy using AF in combination with anti-PD-L1 antibody that warrants further clinical investigation for TNBC patients. 相似文献
2.
BARI NUHOLU ALI AYYILDIZ VECIHI FIDAN ÖZDEN CEBECI UUR KOAR CANKON GERMIYANOLU 《International journal of urology》2006,13(2):109-110
OBJECTIVE: Nocturnal enuresis is a common pediatric problem, the etiology of which is unclear. In recent years, various studies have been published stating that children with nocturnal enuresis exhibit growth and skeletal maturation retardation. METHODS: In this cross-sectional study, we included 27 patients (16 boys, 11 girls) between the ages of 6 and 14 years who had presented with primary nocturnal enuresis (PNE) complaints. We included in the evaluation 19 healthy subjects (12 boys, 7 girls), who were the siblings of the children with PNE, as the control group. RESULTS: The patients in both groups were similar in chronological age, bone age, height and weight, with no significant difference between groups (P>0.05). CONCLUSION: The two groups in our study consisted of the same genetic background. Thus, our results were found to be different from the previous studies. We have concluded that there is no direct relationship between enuresis nocturnal and skeletal maturation. 相似文献
3.
A H Myers B Rosner H Abbey W Willet M J Stampfer C Bain R Lipnick C Hennekens F Speizer 《American journal of public health》1987,77(5):628-630
We analyzed smoking behavior of 91,651 married female nurses, aged 30-55 years in 1976. The prevalence of smoking was similar among all birth cohorts. The largest percentage increase in starting to smoke occurred between ages 15 and 25 years; by age 25, 50 per cent had started smoking. The cessation rate was lowest in earlier birth cohorts and among nurses starting to smoke at earlier ages. The cessation rate increased substantially between 1963-73 compared with the period 1948-58. 相似文献
4.
5.
6.
7.
8.
K F Tait T Marshall J Berman J Carr-Smith B Rowe J A Todd S C Bain A H Barnett S C L Gough 《Diabetic medicine》2004,21(4):358-362
AIMS: Autoimmune disorders co-exist in the same individuals and in families, implying a shared aetiology. The aim of this study was to compare the prevalence of the common autoimmune diseases in the parents of siblings from the Type 1 diabetes Warren repository with the general population. METHODS: Between 1989 and 1996, 505 British families with at least two siblings affected by Type 1 diabetes were recruited. Clinical information was collected regarding the presence of autoimmune disease in the parents and the prevalence of disease in the parents was compared with that expected in the general population. RESULTS: The prevalence of autoimmune disease in the parents was significantly higher in the repository compared with that expected in the general population [P-value = 1.98 x 10(-5) (female), P-value = 1.1 x 10(-8) (male)]. Type 1 diabetes was recorded in 63/1010 (6.2%) parents with a marked paternal preponderance (9.5 vs. 3%P = 0.002). Other autoimmune diseases affected 27% of parents with diabetes and 13.2% of parents without diabetes (P < 0.01). CONCLUSION: These data confirm the importance of family history as a significant risk factor for the development of Type 1 diabetes and support the hypothesis that the common autoimmune diseases share at least some aetiological mechanisms. 相似文献
9.
10.