首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   949篇
  免费   73篇
  国内免费   7篇
耳鼻咽喉   3篇
儿科学   59篇
妇产科学   9篇
基础医学   89篇
口腔科学   29篇
临床医学   163篇
内科学   212篇
皮肤病学   12篇
神经病学   26篇
特种医学   241篇
外科学   61篇
综合类   21篇
预防医学   30篇
眼科学   7篇
药学   33篇
中国医学   5篇
肿瘤学   29篇
  2024年   2篇
  2023年   8篇
  2022年   2篇
  2021年   9篇
  2020年   6篇
  2019年   6篇
  2018年   22篇
  2017年   11篇
  2016年   18篇
  2015年   20篇
  2014年   25篇
  2013年   22篇
  2012年   15篇
  2011年   16篇
  2010年   35篇
  2009年   57篇
  2008年   28篇
  2007年   10篇
  2006年   15篇
  2005年   6篇
  2004年   9篇
  2003年   21篇
  2002年   17篇
  2001年   19篇
  2000年   11篇
  1999年   14篇
  1998年   50篇
  1997年   52篇
  1996年   66篇
  1995年   48篇
  1994年   43篇
  1993年   47篇
  1992年   14篇
  1991年   7篇
  1990年   14篇
  1989年   34篇
  1988年   30篇
  1987年   32篇
  1986年   33篇
  1985年   23篇
  1984年   16篇
  1983年   9篇
  1982年   22篇
  1981年   14篇
  1980年   8篇
  1979年   2篇
  1978年   4篇
  1977年   12篇
  1976年   11篇
  1975年   13篇
排序方式: 共有1029条查询结果,搜索用时 167 毫秒
1.
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma.  相似文献   
2.
3.
4.
5.
6.
7.
8.
9.
10.
We have performed restriction fragment length polymorphism (RFLP) analysis at the low density lipoprotein receptor (LDLR) locus in order to investigate the molecular genetics of familial hypercholesterolemia (FH) in Spain. Firstly, a sample of 50 unrelated patients with a clinical diagnosis of FH was screened for the presence of major rearrangements at this locus by Southern blot analysis of Bgt II digested genomic DNA. Four different mutations were detected, accounting for 8% of the mutant alleles in the Spanish FH sample. Then, we determined the relative allele frequency and estimated linkage disequilibrium between seven RFLPs of the LDLR gene in the remaining 46 FH patients and in 61 normolipidemic controls. Hindi, Avail, Pvu II, Msp I, and Nco I are the most polymorphic sites with individual PIC values higher than 0.28, whereas the Taq I and Stu I sites display low levels of polymorphism. The usefulness of the seven RFLPs to confirm a clinical diagnosis of FH was investigated in 15 FH-families, consisting of 118 individuals, in whom the presence of Familial Defective Apolipoprotein B-100 (FDB) due to the apoB3500 mutation was excluded. Independent haplotypes were constructed for 71 chromosomes: 15 FH and 56 control haplotypes. A total of 14 different haplotypes was found. In 12 families, clinical diagnosis of FH was confirmed by cosegregation analysis, which makes these RFLPs useful for studying the inheritance of the LDLR gene in 80% of Spanish families with FH. Comparison of haplotypes found in the Spanish sample with those found in Swiss and Norwegians suggests heterogeneity of haplotypes among European populations.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号