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Neuhaus Zipora Feiga Gutvirtz Gil Pariente Gali Wainstock Tamar Landau Daniella Sheiner Eyal 《Archives of gynecology and obstetrics》2020,301(1):143-149
Archives of Gynecology and Obstetrics - To evaluate the long-term pediatric neuropsychiatric morbidity of children born to obese patients. A population-based cohort analysis was performed comparing... 相似文献
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Dahl N; Pigg M; Ristoff E; Gali R; Carlsson B; Mannervik B; Larsson A; Board P 《Human molecular genetics》1997,6(7):1147-1152
Severe glutathione synthetase (GS) deficiency is a rare genetic disorder
with neonatal onset. The enzymatic block of the gamma-glutamyl cycle leads
to a generalized glutathione deficiency. Clinically affected patients
present with severe metabolic acidosis, 5- oxoprolinuria, increased rate of
hemolysis and defective function of the central nervous system. The
disorder is inherited in an autosomal recessive mode and, until recently,
the molecular basis has remained unknown. We have sequenced 18 GS alleles
associated with enzyme deficiency and we detected missense mutations by
direct sequencing of cDNAs and genomic DNA. In total, 13 different
mutations were identified. Four patients were found to be compound
heterozygotes and two individuals were apparently homozygous. Reduced
enzymatic activities were demonstrated in recombinant protein expressed
from cDNAs in four cases with different missense mutations. The results
from biochemical analysis of patient specimens, supported by the properties
of the expressed mutant proteins, indicate that a residual activity is
present in affected individuals. Our results suggest that complete loss of
function of both GS alleles is probably lethal. It is postulated that
missense mutations will account for the phenotype in the majority of
patients with severe GS deficiency.
相似文献
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Celiac disease (CD) is a chronic disease treated by maintaining and managing a lifelong restrictive gluten-free diet. The purpose of this study was to develop a mobile application, Plan My C-Day, to promote self-management skills among youth with CD during adolescence—a time when decreased adherence often occurs—and examine its usability among adolescents with CD. Plan My C-Day contains three simulations of activities involving eating out and actions to take when preparing for these events. It was developed and pilot tested by 13 adolescents with CD. Application use and user perception data were collected and analyzed. Participants chose 160 actions within the simulations. For over 75% of participants, the time to complete the simulation decreased from the first to the third (last) simulation by an average of 50%. The average reported usability perception was 3.71 on a scale of 1 to 5, with system ease of use and ease of learning obtaining the highest scores. This study demonstrated that the Plan My C-Day mobile application’s self-management content, features, and functions operated well and that the simulations were easy to understand and complete. Further development will include the option to add self-created activities and adaptation to different languages and cultures. 相似文献
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Andrea Šimić Klarić Zdravko Kolundžić Slavka Galić Vlatka Mejaški Bošnjak 《European journal of paediatric neurology》2012,16(2):132-137
BackgroundAfter intrauterine growth retardation, many minor neurodevelopmental disorders may occur, especially in the motor skills domain, language and speech development, and cognitive functions.AimThe assessment of language development and impact of postnatal head growth in preschool children born with asymmetrical intrauterine growth retardation.MethodsExaminees were born at term with birth weight below the 10th percentile for gestational age, parity and gender. Mean age at the time of study was six years and four months. The control group was matched according to chronological and gestational age, gender and maternal education with mean age six years and five months. There were 50 children with intrauterine growth retardation and 50 controls, 28 girls and 22 boys in each group. For the assessment of language development Reynell Developmental Language Scale, the Naming test and Mottier test were performed.ResultsThere were statistically significant differences (p < 0.05) in language comprehension, total expressive language (vocabulary, structure, content), naming skills and non-words repetition. Statistically significant positive correlations were found between relative growth of the head [(Actual head circumference ? head circumference at birth)/(Body weight ? birth weight)] and language outcome. Children with neonatal complications had lower results (p < 0.05) in language comprehension and total expressive language.ConclusionIntrauterine growth retardation has a negative impact on language development which is evident in preschool years. Slow postnatal head growth is correlated with poorer language outcome. Neonatal complications were negatively correlated with language comprehension and total expressive language. 相似文献
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Ivan Galić Marin Vodanović Stipan Janković Frane Mihanović Enita Nakaš Samir Prohić Elizabeta Galić Hrvoje Brkić 《Journal of Forensic and Legal Medicine》2013,20(1):40-45
BackgroundDental age estimation in children plays an important role in forensic dentistry. The most commonly used method for age estimation was developed by Demirjian in 1973 on a French–Canadian sample. It generally overestimates dental age in many populations. International maturity standards were formed to obtain a predicted age with more confidence when ethnic origin was not available.ObjectivesThe aim of this study was to evaluate the applicability of Chaillet's international scores in the dental age assessment on Bosnian Herzegovinian (BH) children.MethodsOrthopantomograms of 1772 children, 980 girls and 792 boys aged 6.04–14.90 years, were assessed using Chaillet's international maturity tables and curves. The dental ages for both genders were compared to the chronological ages through a paired t-test.ResultsMean overestimation using Chaillet's international maturity standards were 0.09 ± 0.83 for girls and 0.28 ± 0.90 for boys. The absolute accuracy of residuals between the dental and chronological age were 0.65 ± 0.52 years for girls (Median: 0.52 years) and 0.73 ± 0.60 years for boys (Median: 0.57 years).ConclusionThe Polynomial compound formula was recommended to predict dental age with more accuracy for results of international maturity standards on BH children. 相似文献
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Sabina Gallati Simone Hess Dorothea Galié-Wunder Elisabeth Berger-Menz Dominik Böhlen 《Reproductive biomedicine online》2009,18(5):685-694
The objective of this study was to investigate the contribution of cystic fibrosis transmembrane conductance regulator (CFTR) to human infertility and to define screening and counselling procedures for couples asking for assisted reproduction treatment. Extended CFTR mutation screening was performed in 310 infertile men (25 with congenital absence of the vas deferens (CAVD), 116 with non-CAVD azoospermia, 169 with severe oligospermia), 70 female partners and 96 healthy controls. CFTR mutations were detected in the majority (68%) of CAVD patients and in significant proportions in azoospermic (31%) and oligospermic (22%) men. Carrier frequency among partners of infertile men was 16/70, exceeding that of controls (6/96) significantly (P = 0.0005). Thus, in 23% of infertile couples both partners were carriers, increasing the risk for their offspring to inherit two mutations to 25% or 50%. This study emphasizes the necessity to offer extended CFTR mutation screening and counselling not only to patients with CAVD but also to azoospermic and oligozoospermic men and their partners before undergoing assisted reproduction techniques. The identification of rare and/or mild mutations will not be a reason to abstain from parenthood, but will allow adequate treatment in children at risk for atypical or mild cystic fibrosis as soon as they develop any symptoms. 相似文献