全文获取类型
收费全文 | 2881篇 |
免费 | 360篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 125篇 |
妇产科学 | 59篇 |
基础医学 | 352篇 |
口腔科学 | 80篇 |
临床医学 | 390篇 |
内科学 | 513篇 |
皮肤病学 | 190篇 |
神经病学 | 199篇 |
特种医学 | 146篇 |
外科学 | 319篇 |
综合类 | 124篇 |
一般理论 | 1篇 |
预防医学 | 349篇 |
眼科学 | 60篇 |
药学 | 235篇 |
肿瘤学 | 91篇 |
出版年
2021年 | 57篇 |
2020年 | 25篇 |
2019年 | 59篇 |
2018年 | 64篇 |
2017年 | 43篇 |
2016年 | 63篇 |
2015年 | 50篇 |
2014年 | 69篇 |
2013年 | 94篇 |
2012年 | 121篇 |
2011年 | 119篇 |
2010年 | 80篇 |
2009年 | 92篇 |
2008年 | 122篇 |
2007年 | 137篇 |
2006年 | 129篇 |
2005年 | 110篇 |
2004年 | 115篇 |
2003年 | 101篇 |
2002年 | 108篇 |
2001年 | 125篇 |
2000年 | 105篇 |
1999年 | 85篇 |
1998年 | 47篇 |
1997年 | 22篇 |
1996年 | 26篇 |
1995年 | 28篇 |
1994年 | 38篇 |
1993年 | 46篇 |
1992年 | 56篇 |
1991年 | 42篇 |
1990年 | 59篇 |
1989年 | 73篇 |
1988年 | 70篇 |
1987年 | 57篇 |
1986年 | 39篇 |
1985年 | 47篇 |
1984年 | 43篇 |
1983年 | 25篇 |
1982年 | 22篇 |
1981年 | 26篇 |
1979年 | 27篇 |
1978年 | 24篇 |
1976年 | 24篇 |
1974年 | 31篇 |
1973年 | 28篇 |
1972年 | 27篇 |
1971年 | 21篇 |
1970年 | 19篇 |
1967年 | 24篇 |
排序方式: 共有3253条查询结果,搜索用时 15 毫秒
1.
2.
OBJECTIVE: To establish if there is a role for gabapentin or nortriptyline in the treatment of chronic orchialgia. METHODS: Twenty-six consecutive patients with chronic orchialgia were seen in the chronic pain clinic by a multidisciplinary team. A pain questionnaire was completed prior to commencing either gabapentin or nortriptyline. They were reviewed at 3 months and a repeat questionnaire completed. A 50% improvement in pain was considered successful. RESULTS: Complete data was available for 19 patients. Overall, 61.5% of patients commenced on gabapentin and 66.6% of patients commenced on nortriptyline had a greater than 50% improvement in pain. Patients with post-vasectomy testicular pain were considered as a subgroup. None of these patients had a greater than 50% improvement in pain. However, 80% of patients in the subgroup with idiopathic chronic orchialgia had a greater than 50% improvement in pain. CONCLUSION: Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain. 相似文献
3.
What factors influence survival in patients with unresected synchronous liver metastases after resection of colorectal cancer? 总被引:3,自引:0,他引:3
N. Chafai C. L. H. Chan E. L. Bokey O. F. Dent G. Sinclair P. H. Chapuis 《Colorectal disease》2005,7(2):176-181
OBJECTIVE: The aim of this study was to determine whether the survival of patients with untreated synchronous liver metastases after resection of a colorectal cancer was associated with any features of the primary tumour. METHODS: Information for 398 consecutive patients with unresected liver metastases in the period 1971-2001 was examined by multivariate survival analysis. RESULTS: Of 19 clinical and pathological variables considered, survival was independently associated only with residual tumour in a line of resection (hazard ratio (HR) 1.95), venous invasion (HR 1.87), right colonic tumour (HR 1.68), lymph node metastasis (HR 1.54), and extra-hepatic metastasis (HR 1.16); 8.3% of patients had none of these adverse features. Their 2-year overall survival rate was 39.2%, compared with only 16.5% (P < 0.001) in those with one or more adverse features. CONCLUSIONS: These findings may assist in selecting patients most likely to benefit from treatment of hepatic metastases and in counselling patients and their relatives. 相似文献
4.
5.
Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma 总被引:9,自引:3,他引:6
Weisenburger DD; Gordon BG; Vose JM; Bast MA; Chan WC; Greiner TC; Anderson JR; Sanger WG 《Blood》1996,87(9):3860-3868
Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30-positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study. 相似文献
6.
Synovial sarcoma is a rare malignancy that occurs most frequently in the extremities. Its onset and associated symptoms are often insidious and therefore can be misleading. The authors review this primary malignancy and offer a case report to illustrate the importance of including such entities in the differential diagnosis and subsequent treatment of soft tissue masses found in the foot. 相似文献
7.
8.
9.
Kalevi Laitinen David Sinclair Maria Nurmi Reija Hietala Heikki Kröger Kalervo Kiianmaa Mikko Salaspuro 《Alcoholism, clinical and experimental research》1992,16(5):875-880
Previous work has shown that calcitonin inhibits eating by rats and that it affects several neurotransmitter systems suspected to play a role in alcohol consumption. The present study was an initial test of whether calcitonin does affect voluntary alcohol consumption by male Wistar rats with prolonged alcohol experience. Calcitonin (20 IU/kg) or saline was injected subcutaneously on 10 consecutive days when the rats (n = 20) had continual access to 10% (v/v) ethanol solution, and to food and water. Using a cross-over design, the effects of 40 IU/kg calcitonin vs. saline were then examined in a second 10-day treatment period. Similar patterns of effects were obtained with both calcitonin doses, but the patterns differed with alcohol, food, and water intake. Alcohol drinking showed biphasic changes with both doses, producing highly significant Treatment x Day interactions (p < 1E-10 and p = 6E-7): it was significantly reduced on the first day of calcitonin treatment and significantly increased on the last few days. Food intake was reduced on all calcitonin days although most markedly on the first. Water drinking was not altered on the first calcitonin day, but was greatly increased on the second, then gradually returned toward the baseline. In a second experiment, the animals were switched to 1 hr of alcohol access per day, and calcitonin (20 IU/kg) was administered periodically to one group 4 hr before the alcohol access. Alcohol drinking was significantly reduced in all cases when the calcitonin injection was preceded by at least 1 day without calcitonin.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.