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排序方式: 共有209条查询结果,搜索用时 418 毫秒
1.
Joseph Wheatley Zhengyang Liu Joel Loth Mark P. Plummer Jahan C. Penny-Dimri Reny Segal Julian Smith Luke A. Perry 《Acta anaesthesiologica Scandinavica》2023,67(2):131-141
Background
Patients undergoing cardiac surgery are at significant risk of developing postoperative acute kidney injury (AKI). Neutrophil–lymphocyte ratio (NLR) is a widely available inflammatory biomarker which may be of prognostic value in this setting.Methods
We conducted a systematic review and meta-analysis of studies reporting associations between perioperative NLR with postoperative AKI. We searched Medline, Embase and the Cochrane Library, without language restriction, from inception to May 2022 for relevant studies. We meta-analysed the reported odds ratios (ORs) with 95% confidence intervals (CIs) for both elevated preoperative and postoperative NLR with risk of postoperative AKI and need for renal replacement therapy (RRT). We conducted a meta-regression to explore inter-study statistical heterogeneity.Results
Twelve studies involving 10,724 participants undergoing cardiac surgery were included, with eight studies being deemed at high risk of bias using PROBAST modelling. We found statistically significant associations between elevated preoperative NLR and postoperative AKI (OR 1.45, 95% CI 1.18–1.77), as well as postoperative need for RRT (OR 2.37, 95% CI 1.50–3.72). Postoperative NLR measurements were not of prognostic significance.Conclusions
Elevated preoperative NLR is a reliable inflammatory biomarker for predicting AKI following cardiac surgery. 相似文献2.
Weiss Roxanne Loth Andreas Leinung Martin Balster Sven Hirth Daniel Stöver Timo Helbig Silke Kramer Sabine 《European archives of oto-rhino-laryngology》2020,277(3):751-759
European Archives of Oto-Rhino-Laryngology - The objective of this prospective, single-subject, repeated measures study was to evaluate the audiological benefit and patient satisfaction with an... 相似文献
3.
Liu J Juo SH Terwilliger JD Grunn A Tong X Brito M Loth JE Kanyas K Lerer B Endicott J Penchaszadeh G Gilliam TC Baron M 《American journal of medical genetics》2001,105(2):189-194
Evidence for linkage between bipolar affective disorder (BP) and 21q22 was first reported by our group in a single large pedigree with a lod score of 3.41 with the PFKL locus. In a subsequent study, with denser marker coverage in 40 multiplex BP pedigrees, we reported supporting evidence with a two-point lod score of 2.76 at the D21S1260 locus, about 6 cM proximal to PFKL. For cost-efficiency, the individuals genotyped in that study comprised a subset of our large pedigree sample. To augment our previous analysis, we now report a follow-up study including a larger sample set with an additional 331 typed individuals from the original 40 families, improved marker coverage, and an additional 16 pedigrees. The analysis of all 56 pedigrees (a total of 862 genotyped individuals vs. the 372 genotyped previously), the largest multigenerational BP pedigree sample reportedly analyzed to date, supports our previous results, with a two-point lod score of 3.56 with D21S1260. The 16 new pedigrees analyzed separately gave a maximum two-point lod score of 1.89 at D21S266, less than 1 cM proximal to D21S1260. Our results are consistent with a putative BP locus on 21q22. 相似文献
4.
5.
Eduardo Alexandre Loth Samia Khalil Biazim José Henrique Fermino Ferreira dos Santos Rosana Puccia Rosimeire Costa Brancalh?o Lucinéia de Fátima Chasco Rinaldo Ferreira Gandra Rita de Cássia Garcia Sim?o Marcello Fabiano de Franco 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(3):259-264
Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus
Paracoccidioides brasiliensis (Pb) and corresponds to prevalent
systemic mycosis in Latin America. The aim of the present work was to evaluate the
dose response effect of the fungal yeast phase for the standardization of an
experimental model of septic arthritis. The experiments were performed with groups of
14 rats that received doses of 103, 104 or 105
P. brasiliensis (Pb18) cells. The fungi were injected in 50 µL of
phosphate-buffered saline (PBS) directly into the knee joints of the animals. The
following parameters were analyzed in this work: the formation of swelling in knees
infused with yeast cells and the radiological and anatomopathological alterations,
besides antibody titer by ELISA. After 15 days of infection, signs of inflammation
were evident. At 45 days, some features of damage and necrosis were observed in the
articular cartilage. The systemic dissemination of the fungus was observed in 11% of
the inoculated animals, and it was concluded that the experimental model is able to
mimic articular PCM in humans and that the dose of 105 yeast cells can be
used as standard in this model. 相似文献
6.
Family meals and disordered eating in adolescents: Are the benefits the same for everyone? 下载免费PDF全文
7.
Mary J. Christoph Katie A. Loth Marla E. Eisenberg Ann F. Haynos Nicole Larson Dianne Neumark-Sztainer 《Journal of nutrition education and behavior》2018,50(3):267-274.e1
Objective
Investigate the relationship between use of Nutrition Facts labels on packaged foods and weight-related behaviors.Design
Cross-sectional survey in 2015–2016.Participants
Young adult respondents (n?=?1,817; 57% women; average age 31.0?±?1.6 years) to the Project Eating and Activity in Teens and Young Adults–IV survey, the fourth wave of a longitudinal cohort study.Variables Measured
Use of Nutrition Facts labels on packaged foods; healthy, unhealthy, and extreme weight control behaviors; intuitive eating; binge eating.Analysis
Linear and logistic regression models were adjusted for age, ethnicity/race, education, income, and weight status.Results
In women, greater Nutrition Facts use was associated with a 23% and 10% greater likelihood of engaging in healthy and unhealthy weight control behaviors, respectively, and a 17% greater chance of engaging in binge eating. In men, greater label use was associated with a 27% and 17% greater likelihood of engaging in healthy and unhealthy weight control behaviors, respectively, and a lower level of intuitive eating.Conclusions and Implications
Professionals advising patients and clients on weight management may consider possible gender differences in response to weight loss and management guidance. Since label use was related to engagement in some unhealthy behaviors in addition to healthy behaviors, it is important to consider how individuals may use labels, particularly those at risk for, or engaging in, disordered eating behaviors. Future research investigating potential relationships between Nutrition Facts use, intuitive eating, and binge eating is needed. 相似文献8.
Loth F. L. Giesinger J. M. Giesinger K. Howie C. R. Hamilton D. F. 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(2):267-274
European Journal of Orthopaedic Surgery & Traumatology - Single-item questions assessing patient satisfaction following total hip or knee arthroplasty (THA/TKA) provide immediate and... 相似文献
9.
Jelka Tzschoppe Frauke Nees Tobias Banaschewski Gareth J Barker Christian Büchel Patricia J Conrod Hugh Garavan Andreas Heinz Eva Loth Karl Mann Jean-Luc Martinot Michael N Smolka Jürgen Gallinat Aandreas Str?hle Maren Struve Marcella Rietschel Gunter Schumann Herta Flor IMAGEN consortium 《Neuropsychopharmacology》2014,39(4):875-884
Neuroticism involves a tendency for enhanced emotional and cognitive processing of negative affective stimuli and a propensity to worry and be anxious. It is known that this trait modulates fear learning and the activation of brain regions involved in it such as the amygdala, hippocampus, and prefrontal cortex and their connectivity. Thirty-nine (21 female) 14-year-old healthy adolescents participated in functional magnetic resonance imaging (fMRI) of aversive pavlovian differential delay conditioning. An unpleasant sound served as unconditioned stimulus (US) and pictures of neutral male faces as conditioned stimuli (CS+ followed by the US in 50% of the cases; CS− never followed by the US). During acquisition (CS+/− differentiation), higher levels of neuroticism were associated with a stronger interaction between the right amygdala and the right hippocampus as well as the right amygdala and prefrontal cortical regions, specifically ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and anterior cingulate cortex. The association of stronger conditionability of fear and connectivity of brain regions related to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhanced propensity for anxiety disorders in highly neurotic participants. This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders. 相似文献
10.