全文获取类型
收费全文 | 4854篇 |
免费 | 407篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 126篇 |
妇产科学 | 99篇 |
基础医学 | 726篇 |
口腔科学 | 55篇 |
临床医学 | 687篇 |
内科学 | 820篇 |
皮肤病学 | 43篇 |
神经病学 | 530篇 |
特种医学 | 195篇 |
外科学 | 517篇 |
综合类 | 111篇 |
一般理论 | 5篇 |
预防医学 | 562篇 |
眼科学 | 69篇 |
药学 | 365篇 |
中国医学 | 6篇 |
肿瘤学 | 295篇 |
出版年
2023年 | 25篇 |
2021年 | 84篇 |
2020年 | 43篇 |
2019年 | 84篇 |
2018年 | 97篇 |
2017年 | 69篇 |
2016年 | 75篇 |
2015年 | 85篇 |
2014年 | 122篇 |
2013年 | 179篇 |
2012年 | 260篇 |
2011年 | 278篇 |
2010年 | 137篇 |
2009年 | 117篇 |
2008年 | 240篇 |
2007年 | 261篇 |
2006年 | 228篇 |
2005年 | 233篇 |
2004年 | 242篇 |
2003年 | 205篇 |
2002年 | 189篇 |
2001年 | 144篇 |
2000年 | 141篇 |
1999年 | 147篇 |
1998年 | 47篇 |
1997年 | 47篇 |
1996年 | 35篇 |
1995年 | 39篇 |
1994年 | 36篇 |
1992年 | 110篇 |
1991年 | 95篇 |
1990年 | 91篇 |
1989年 | 77篇 |
1988年 | 70篇 |
1987年 | 68篇 |
1986年 | 73篇 |
1985年 | 85篇 |
1984年 | 48篇 |
1983年 | 54篇 |
1982年 | 28篇 |
1981年 | 33篇 |
1980年 | 35篇 |
1979年 | 48篇 |
1978年 | 39篇 |
1977年 | 24篇 |
1976年 | 29篇 |
1974年 | 35篇 |
1973年 | 27篇 |
1972年 | 34篇 |
1970年 | 26篇 |
排序方式: 共有5270条查询结果,搜索用时 234 毫秒
1.
Sarina A. Piha-Paul Do-Youn Oh Makoto Ueno David Malka Hyun Cheol Chung Adnan Nagrial Robin K. Kelley Willeke Ros Antoine Italiano Kazuhiko Nakagawa Hope S. Rugo Filippo de Braud Andrea Iolanda Varga Aaron Hansen Hui Wang Suba Krishnan Kevin G. Norwood Toshihiko Doi 《International journal of cancer. Journal international du cancer》2020,147(8):2190-2198
We present data from patients with advanced biliary tract cancer (BTC) receiving pembrolizumab in the KEYNOTE-158 (NCT02628067; phase 2) and KEYNOTE-028 (NCT02054806; phase 1b) studies. Eligible patients aged ≥18 years from both studies had histologically/cytologically confirmed incurable BTC that progressed after standard treatment regimen(s), measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, Eastern Cooperative Oncology Group performance status 0/1, and no prior immunotherapy. Programmed death ligand 1 (PD-L1)-positive tumors were required for eligibility in KEYNOTE-028 only. Patients received pembrolizumab 200 mg every three weeks (KEYNOTE-158) or 10 mg/kg every two weeks (KEYNOTE-028) for ≤2 years. Primary efficacy endpoint was objective response rate (ORR) by RECIST v1.1. Response assessed by independent central review is reported. KEYNOTE-158 enrolled 104 patients and KEYNOTE-028 enrolled 24 patients. Median (range) follow-up was 7.5 months (0.6-34.3) in KEYNOTE-158 and 5.7 months (0.6-55.4) in KEYNOTE-028. In KEYNOTE-158, ORR was 5.8% (6/104; 95% CI, 2.1%-12.1%); median duration of response (DOR) was not reached (NR) (range, 6.2-26.6+ months). Median (95% CI) OS and PFS were 7.4 (5.5-9.6) and 2.0 (1.9-2.1) months. Among PD-L1-expressers (n = 61) and PD-L1-nonexpressers (n = 34), respectively, ORR was 6.6% (4/61) and 2.9% (1/34). In KEYNOTE-028, ORR was 13.0% (3/23; 95% CI, 2.8%-33.6%); median DOR was NR (range, 21.5-53.2+ months). Median (95% CI) OS and PFS were 5.7 (3.1-9.8) and 1.8 (1.4-3.1) months. Grade 3 to 5 treatment-related adverse events occurred in 13.5% of patients in KEYNOTE-158 (no grade 4; grade 5 renal failure, n = 1) and 16.7% in KEYNOTE-028 (no grade 4/5). In summary, pembrolizumab provides durable antitumor activity in 6% to 13% of patients with advanced BTC, regardless of PD-L1 expression, and has manageable toxicity. 相似文献
2.
Nicole L. Stout DPT Justin C. Brown PhD Anna L. Schwartz PhD FNP Timothy F. Marshall PhD Anna M. Campbell PhD MBE Larissa Nekhlyudov MD MPH David S. Zucker MD PhD Karen M. Basen-Engquist PhD MPH Grace Campbell PhD MSW RN Jeffrey Meyerhardt MD MPH Andrea L. Cheville MD MSSE Kelley R. Covington MS Jennifer A. Ligibel MD Jonas M. Sokolof DO Kathryn H. Schmitz PhD MPH Catherine M. Alfano PhD 《Cancer》2020,126(12):2750-2758
3.
4.
Neil H Pliskin Alia N Ammar Joseph W Fink S Kristian Hill Aaron C Malina Alona Ramati Kathleen M Kelley Raphael C Lee 《Journal of the International Neuropsychological Society》2006,12(1):17-23
The clinical presentation of electrical injury commonly involves physical, cognitive, and emotional complaints. Neuropsychological studies, including case reports, have indicated that electrical injury (EI) survivors may experience a broad range of impaired neuropsychological functions, although this has not been clarified through controlled investigation. In this study, we describe the neuropsychological test findings in a series of 29 EI patients carefully screened and matched to a group of 29 demographically similar healthy electricians. Participants were matched by their estimated premorbid intellectual ability. Multivariate analysis of variance was used to assess group differences in the following neuropsychological domains: attention and mental speed, working memory, verbal memory, visual memory, and motor skills. EI patients performed significantly worse on composite measures of attention/mental speed and motor skills, which could not be explained by demographic differences, injury parameters, litigation status, or mood disturbance. Results suggest that cognitive changes do occur in patients suffering from electrical injury. 相似文献
5.
Background
Exercise has been recommended for improving global-well being in adults with fibromyalgia. However, no meta-analysis has determined the effects of exercise on global well-being using a single instrument and when analyzed separately according to intention-to-treat and per-protocol analyses. The purpose of this study was to fill that gap. 相似文献6.
Joyce J. Fitzpatrick Sheila Ryan DeWitt Baldwin Roger Bulger Jean Johnson-Pawlson Christopher McLaughlin Maureen Kelley Leopold Selketr Bernardine Lacey Charlene Hanson Robin Harvan Patricia Hinton Walker David Sluyter Mary Joan Ladden Neal Vanselow 《Journal of Midwifery & Women's Health》1998,43(1):61-65
In 1995, the National League for Nursing commissioned a Panel on Interdisciplinary/Transdisciplinary Education. The focus of the Panel's work was to examine educational issues that transcend the health professions and to make recommendations for future implementation of an interdisciplinary approach to addressing them. This article is being simultaneously published by several professional journals. The goal is to seek as much feedback as possible. 相似文献
7.
8.
R E Kelley 《Pediatric neurology》1986,2(2):111-114
Two patients with ischemic strokes, presumably due to embolism, developed spontaneous hemorrhagic cerebral infarctions which were detected by follow-up cranial computed tomography. Clinical deterioration was associated with hemorrhagic transformation in one patient. In each case, immediate anticoagulant therapy was considered but was deferred. Implications of the use of anticoagulant therapy in pediatric patients with acute embolic stroke are discussed. 相似文献
9.
Michael W Ross Amy Jo Harzke Deborah P Scott Kelly McCann Michael Kelley 《AIDS education and prevention》2006,18(6):504-517
We report select outcomes from an evaluation of Project Wall Talk, a community-based, peer-led HIV prevention education program implemented in 36 Texas State prison units. Peer educators completed questionnaires prior to receipt of a 40-hour intensive training (N = 590) and at 9-month follow-up (N = 257). Students (N = 2506) completed questionnaires pre- and post-receipt of peer educator-led HIV education sessions. Peer educators and their students showed significant increases in HIV-related knowledge. Peer educators showed significant increases in assessment of their skills as educators. For both peer educators and students, significant differences in HIV-related knowledge were indicated across categories of prior educational level attained and race/ethnicity; no such differences were indicated at follow-up. Compared with baseline, a significantly greater proportion of peer educators reported ever having had an HIV test. After receiving peer-led education, a significantly smaller proportion of students reported they knew their HIV status and more indicated plans to take an HIV test. Additionally, in months 12 and 18 following program implementation, the numbers of HIV tests at the five units that implemented the peer education program were roughly twice that of five, matched comparison units without the peer education program. Based on peer educator reports, we projected that peer educators (N = 257) may have as many as 84,000 or more annual opportunities to share HIV-related knowledge with other prisoners outside the classroom. 相似文献
10.
W N Kelley 《Annals of internal medicine》1991,114(8):697-698