Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood through adulthood, men have a higher incidence of stroke compared with women. Abundant research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in stroke. Au...     

Establishment of an optimized CTC detection model consisting of EpCAM,MUC1 and WT1 in epithelial ovarian cancer and its correlation with clinical characteristics

Objective: Emerging studies have demonstrated the promising clinical value of circulating tumor cells(CTCs)for diagnosis, disease assessment, treatment monitoring and prognosis in epithelial ovarian cancer. However, the clinical application of CTC remains restricted due to diverse detection techniques with variable sensitivity and specificity and a lack of common standards.Methods: We enrolled 160 patients with epithelial ovarian cancer as the experimental group, and 90 patients including 50 pat...     

Glial regenerative response in the imaginal discs of Drosophila melanogaster

<正>Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional plasticity.In response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior     

Tandem pore TWIK-related potassium channels and neuroprotection

TWIK-related potassium channels(TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notwithstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.     

基于常规多参数MRI的深度学习全自动检测并分割脑膜瘤

正目的 MRI是脑膜瘤影像检查方法的选择之一。脑膜瘤的容积测量与治疗规划及监测高度相关。采用基于多个转诊机构常规MRI数据的多参数深度学习模型(DLM)自动     

CT影像评估不透射线药物洗脱微球经动脉化学栓塞术后药物剂量在兔肿瘤模型中的分布

正摘要目的探讨在兔肿瘤模型中用不透射线的药物洗脱微球(DEB)行经动脉化学栓塞术(TACE)后,CT影像中微球的位置和衰减情况与进入肝脏的药物含量和分布之间的     

低对比度低密度局灶性小病灶的CT检测能力:迭代重建与滤过反投影重建

正摘要目的研究在11种不同的辐射剂量下两大CT设备公司滤过反投影(FBP)和迭代重建(IR)算法分别对低对比度低密度小病灶(≤1cm)的检测能力。材料与方法低对比     

多参数MR成像全肿瘤直方图分析三阴性乳腺癌与其他亚型的鉴别

正摘要目的利用多参数MR成像图谱和全肿瘤直方图分析三阴性(TN)乳腺癌与其他分子亚型鉴别的影像学生物标志。方法本回顾性研究包括134例浸润性导管癌病人。从