全文获取类型
收费全文 | 68498篇 |
免费 | 6029篇 |
国内免费 | 2764篇 |
专业分类
耳鼻咽喉 | 738篇 |
儿科学 | 1651篇 |
妇产科学 | 1369篇 |
基础医学 | 7170篇 |
口腔科学 | 1266篇 |
临床医学 | 6568篇 |
内科学 | 6885篇 |
皮肤病学 | 835篇 |
神经病学 | 2543篇 |
特种医学 | 3542篇 |
外国民族医学 | 54篇 |
外科学 | 8610篇 |
综合类 | 11199篇 |
现状与发展 | 22篇 |
预防医学 | 2154篇 |
眼科学 | 630篇 |
药学 | 4729篇 |
50篇 | |
中国医学 | 2091篇 |
肿瘤学 | 15185篇 |
出版年
2024年 | 186篇 |
2023年 | 1051篇 |
2022年 | 2257篇 |
2021年 | 2963篇 |
2020年 | 2400篇 |
2019年 | 2148篇 |
2018年 | 2004篇 |
2017年 | 2279篇 |
2016年 | 2573篇 |
2015年 | 2745篇 |
2014年 | 4280篇 |
2013年 | 4351篇 |
2012年 | 3754篇 |
2011年 | 4232篇 |
2010年 | 3423篇 |
2009年 | 3461篇 |
2008年 | 3462篇 |
2007年 | 3713篇 |
2006年 | 3319篇 |
2005年 | 2917篇 |
2004年 | 2537篇 |
2003年 | 2144篇 |
2002年 | 1966篇 |
2001年 | 1765篇 |
2000年 | 1444篇 |
1999年 | 1319篇 |
1998年 | 1133篇 |
1997年 | 1030篇 |
1996年 | 919篇 |
1995年 | 825篇 |
1994年 | 702篇 |
1993年 | 550篇 |
1992年 | 459篇 |
1991年 | 382篇 |
1990年 | 301篇 |
1989年 | 294篇 |
1988年 | 278篇 |
1987年 | 244篇 |
1986年 | 182篇 |
1985年 | 241篇 |
1984年 | 215篇 |
1983年 | 139篇 |
1982年 | 173篇 |
1981年 | 145篇 |
1980年 | 94篇 |
1979年 | 97篇 |
1978年 | 72篇 |
1977年 | 46篇 |
1976年 | 39篇 |
1975年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
严桂英 《中国卫生标准管理》2020,(8):95-98
目的探究益气养精法对老年肺癌患者肿瘤标志物、生存期影响。方法研究纳入60例老年肺癌患者,均由本院2016年1月-2017年1月收治,采取随机数字表法将患者分为两组,对照组患者(30例)常规化疗治疗,观察组患者(30例)在化疗基础上联合益气养精法治疗,比较两组患者治疗效果、治疗前后癌胚抗原(carcino-embryonic antigen,CEA)及血清癌抗原125(serum oncoantigen 125,CA 125)肿瘤标志物水平、不良反应情况及患者2年生存率。结果观察组患治疗有效率高于对照组,P<0.05;治疗前,两组患者CEA及CA 125水平相当,P>0.05,治疗后均改善,观察组优于对照组,P<0.05;观察组患者不良反应与对照组相当,均较低,P>0.05;观察组患者2年生存率高于对照组,P<0.05。结论益气养精法治疗老年肺癌患者效果患者,患者症状改善,不良反应少,安全可靠,且患者2年生存率较高。 相似文献
2.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
3.
4.
5.
6.
Fahad Ali Rahul Smita Jyoti Ambreen Fatima Saba Khanam Falaq Naz Yasir Hasan Siddique 《Scientia pharmaceutica》2016,84(2):361-377
The present investigation was aimed at studying the possible role of curcumin against N-nitrosodiethylamine (NDEA)-induced toxicity in albino rats. Administration of NDEA to rats at a concentration of 0.1 mg/ml in drinking water ad libitum for 21 days produced toxicity in them, which was evident from histopathological changes in the rat livers, and increased levels of blood serum enzyme markers, i.e. aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase. In addition, the levels of oxidative stress markers like lipid peroxidation (LPO), protein carbonyl (PCC), and glutathione-S-transferase (GST) activity were elevated and the total glutathione (GSH) content was reduced in the livers. The administration of curcumin to rats at concentrations of 10, 20, and 40 mg/ml in drinking water along with 0.1 mg/ml of NDEA for 21 days effectively suppressed NDEA-induced toxicity and also resulted in a dose-dependent reduction in the levels of blood serum enzyme markers (AST, ALT, ALP, and LDH). Moreover, LPO, PCC, and GST activity were reduced and the GSH level was increased upon the administration of curcumin along with NDEA. The results obtained for the comet assay in rat hepatocytes and blood lymphocytes showed a significant dose-dependent decrease in the mean tail length. The micronucleus assay performed on rat hepatocytes also showed a dose-dependent reduction in the frequency of micronucleated cells along with curcumin administration. These results suggest that curcumin has a protective role against NDEA-induced toxicity in albino rats. 相似文献
7.
8.
Gregory N. Gan 《Expert opinion on investigational drugs》2016,25(10):1153-1166
Introduction: Cancer treatment is moving away from conventional cytotoxic drugs and towards agents that target specific proteins and mechanisms important to cancer development or survival. The Hedgehog Pathway (HhP) is a signal transduction pathway and its constitutive activation is tumorigenic in basal cell carcinoma (BCC). The HhP enables phenotypic flexibility, and channels tumor-stroma interactions. As a result, it is over-expressed in numerous cancers as well as in the tumor microenvironment and may represent a promising therapeutic target.Areas covered: In this article, we review the rationale for targeting HhP and its role as an oncogenic driver, in tumor epithelial-to-mesenchymal transition (EMT), and in the tumor microenvironment and describe the results of preclinical and clinical studies involving HhP inhibitors.Expert opinion: HhP activation plays an important role in both the tumor microenvironment and tumor EMT which can lead to treatment resistance for a number of different malignancies. In addition to standard use in BCC, several HhP inhibitors are in preclinical, early, and mid-stage clinical development for other solid and hematologic malignancies. 相似文献
9.
Oral Everolimus for Treatment of a Giant Left Ventricular Rhabdomyoma in a Neonate—Rapid Tumor Regression Documented by Real Time 3D Echocardiography 下载免费PDF全文
Robert Wagner M.D. Ph.D. Frank Thomas Riede M.D. Hiroshi Seki M.D. Frauke Hornemann M.D. Steffen Syrbe M.D. Ingo Daehnert M.D. Ph.D. Michael Weidenbach M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(12):1876-1879
The presented case reports on successful treatment with everolimus in a neonate with left ventricular giant rhabdomyoma. The authors used a different dosage regime compared to literature and documented rapid tumor regression by 3D echocardiography. 相似文献
10.