溃疡宁治疗十二指肠球部溃疡活动期疗效观察

本文报告口服纯中药制剂溃疡宁片6周,治疗十二指肠球部溃疡活动期的近期治愈率为61.1%,总有效率为100%,消除各种症状的效果较好,与雷尼替丁对照组的疗效基本相同(P>0.05),而且未发现明显的毒副作用。同时,溃疡宁片对十二指肠球部溃疡活动期的各个中医证型的临床治愈率也基本相同(P>0.05)。提示溃疡宁片适应于十二指肠球部溃疡活动期中医各证型患者,是治疗十二指肠球部溃疡活动期有较好效果的固定方剂。     

Reversal of dexfenfluramine-induced anorexia and c-Fos/c-Jun expression by lesion in the lateral parabrachial nucleus

The external subdivision of the lateral parabrachial nucleus (LPBE) shows strong Fos-like immunoreactivity (FLI) following anorectic doses of the indirect serotonin agonist dexfenfluramine (DFEN). In an effort to determine the contribution of the LPBE to DFEN-induced anorexia, bilateral ibotenate lesions were made in the LPBE, and the effects of the lesion on DFEN-induced anorexia and FLI as well as c-June-like immunoreactivity (JLI) were examined. It was found that LPBE lesion significantly attenuated DFEN anorexia: in a 1-h food intake test following 24-h food deprivation, DFEN (2 mg/kg) suppressed food intake by 60% in intact rats but only 34% in rats with LPBE lesions. In addition to this behavioral change, LPBE lesion completely abolished DFEN-induced FLI and JLI in the lateral subdivision of the central nucleus of the amygdala (CeL) and laterodorsal subdivision of the bed nucleus of stria terminalis (BSTLD), both of which showed strong FLI and JLI in intact rats. DFEN-induced FLI and JLI in other brain regions were not affected by LPBE lesion, including the ventromedial and lateral hypothalamus, caudate-putamen, and the nucleus of the solitary tract (NST). The parallel loss of DFEN-induced anorexia and FLI/JLI following LPBE lesion raises the novel possibility that LPBE-CeL/BSTLD pathway may be involved in DFEN anorexia.     

脉君安与巯甲丙脯酸,硝苯吡啶联合应用治疗高血压病临床分析

１３２例高血压病患者随机分为二组，观察组７６例采用脉君安与巯甲丙脯酸、硝苯吡联合应用。对照组５６例采用巯甲丙脯酸、硝比啶联合应用。共用４周，结果降压总有依次为９７．３６％、８５．７１％；副作用发生率依次为２．６３％、，１７．８６％。未见明显的电解质、血糖和血脂变化，提示脉群安与巯甲丙酸，硝苯吡啶联合应用可以提高降压疗效减少副作用。     

试从小儿阳气特点探讨通阳法的应用

通过对小儿阳气特点的探讨,认为小儿阳多阴少乃是小儿生长发育过程中的需要,而阳气郁遏往往成为小儿疾患常见的原因,通阳法通过使郁遏之阳气得以舒展、畅通,宣泄、从而达到阳通阴和,重新获得阴阳平衡的目的。     

中药对脊髓损伤大鼠背根神经节c-Jun表达的影响

应用荧光免疫组化法及激光扫描共聚焦显微镜技术 ,探索中药脊髓Ⅰ号促进大鼠损伤脊髓修复再生的机制。结果表明 ,服用脊髓I号后脊髓损伤侧背根节神经元的c Jun表达明显上调 ;脊髓损伤侧背根节神经元的细胞核呈完整形态的数量明显增多。提示脊髓Ⅰ号可能通过对c Jun基因表达的调节 ,激发损伤脊髓组织的修复再生     

杨振国教授术柏痛风汤治疗痛风52例

[目的]观察杨振国术柏痛风汤治疗痛风疗效。[方法]将52例痛风使用术柏痛风汤,1剂/d,早晚各1次,水煎服。15d为1疗程。治疗3个疗程进行疗效判定。[结果]临床治愈32例,显效11例,有效5例,无效4例,总有效率为92.31%。[结论]术柏痛风汤治疗痛风疗效满意,值得推广。