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排序方式: 共有133条查询结果,搜索用时 15 毫秒
1.
目的:通过数据挖掘的方法,探寻朴炳奎教授治疗肺癌靶向治疗患者及靶向治疗导致皮疹患者的用药规律,用客观数据总结其临床经验。方法:采用联机处理分析和复杂网络分析方法,对朴炳奎教授临床诊疗电子信息化模板的数据库中37例肺癌靶向治疗患者的病历资料进行回顾性分析(其中包含14例皮疹患者)。结果:通过数据挖掘,显示出朴师处方的核心思想以益气健脾为主,结合化痰祛湿、清热解毒为治则,体现出扶正与祛邪、辨病与辨证、局部与整体相结合的学术思想。结合专家访谈的形式,确立解毒消疹方的组成。结论:数据挖掘的结果与朴师治疗肺癌的扶正固本、祛邪解毒相结合的中西医结合学术思想得到了相互印证;确立了解毒消疹方的组成,即白芍、金银花、地肤子、蝉蜕。  相似文献   
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Fear is the most common response to disease outbreaks. Persistent and prolonged fear can elevate the levels of psychological distress and aggravate preexisting mental health problems. Therefore, prompted by the central role of fear in psychological responses to COVID-19, the Fear of COVID-19 Scale was developed, which is the only instrument that can assess emotional fear reactions in relation to the current pandemic. In this study, we extend research on the psychometric properties of this instrument by adopting three complementary approaches: classical test theory, Rasch analysis, and Mokken analysis. Combining these methods allows for a more nuanced overview of the psychometric properties of the instrument. The sample comprised South African teachers (n = 355) who completed the Fear of COVID-19 Scale. All three approaches confirmed the reliability and the construct, convergent, and concurrent validity of the scale as used with South African teachers. In addition, all three approaches confirmed that the scale is sufficiently homogenous to be considered unidimensional.  相似文献   
4.
目的:探究利伐沙班导致皮疹的特点,为患者安全用药提供参考。方法:检索国内外数据库,获得利伐沙班致皮疹的病例报道文献,对病例的患者年龄、性别、既往病史,利伐沙班使用目的、使用剂量、联合用药,药品不良反应(ADR)出现时间、临床表现、处理、预后等信息,以及ADR关联性评价结果进行统计分析。结果:共检索获得16篇文献(16例患者)。ADR患者男女比例为1∶1,>60岁老年患者11例(68. 7%)。16例患者中14例的利伐沙班给药剂量符合药品说明书规定,12例患者联用了其他药物;5例(31. 3%)患者用药后第3天出现皮疹,3例(18. 8%)在用药10 d时出现。16例均出现全身多处散在红斑,其中8例明确诊断为伴嗜酸粒细胞增多及系统症状的药疹综合征、特发性血小板减少性紫癜、白细胞破碎性血管炎、血清病和神经性水肿;患者经治疗后症状改善。5例患者关联性评价为"很可能有关",11例为"可能有关"。结论:临床工作中要关注利伐沙班导致的皮疹,长期服药患者仍应引起重视。  相似文献   
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目的:探寻中医对EGFR-TKI相关皮疹的治法及用药规律,为进一步临床应用及研究提供思路。方法:采用计算机检索与人工检索结合的方法,对中医治疗EGFR-TKI相关皮疹的文献进行分析,应用Frequencie法进行数据处理。结果:共纳入论文18篇,共用药192味次,高频药物依次为生甘草、金银花、生地黄。高频药物性多为寒;药味多为甘、苦、辛;归经多为心、肝、胃、肺经;证型多见风热型、湿热型、血热型。治法可分为祛邪及扶正两方面,祛邪包括:清热、疏风、凉血、祛湿、化痰、化瘀、解毒、理气8法,扶正包括:养阴、养血、补气3法,单用祛邪者占44.4%,单用扶正者5.6%,攻补兼施者50%。处方涉及五味消毒饮、疏风解毒消疹方、银翘散、凉血消风散、荆防四物汤等。结论:目前对EGFR-TKI相关皮疹的中医治疗尚未形成统一的规范,治则治法尚属摸索阶段,临证多以“热”、“虚”、“风”、“毒”、“湿”为辨证要点,以“清热”、“疏风”、“补虚”为治疗要点。在今后的实践中,有必要展开大样本的临床试验,以期对中药治疗有更具体的指导意义。  相似文献   
7.
刘兵  陈惠仁 《河北医学》2013,(11):1664-1667
目的:分析儿童过敏性紫癜临床特点及肾损害相关因素。方法:选择过敏性紫癜患儿122例,将伴有肾脏功能损害者选入观察组(49例),将不伴有肾脏功能损害者选入对照组(73例),分析所有患儿临床资料,对过敏性紫癜患儿诱因及首发症状情况、临床表现及过敏性紫癜患儿肾脏功能损害的危险因素进行探讨。结果:感染为患儿最常见诱因,比例为52.46%,紫癜为患儿最常见的首发症状,比例为64.75%。临床表现包括过敏性紫癜皮疹、关节症状、消化道症状及肾脏功能损害。卡方检验显示,观察组患儿年龄≥8y、皮疹反复≥4w及血FIB升高的比例均显著高于对照组患儿,差异具有统计学意义(P〈0.05)。Logistic多因素分析显示皮疹反复发生≥4w及血FfB水平升高是过敏性紫癜患儿肾脏功能损害的重要危险因素。结论:典型的皮疹、关节症状、消化道症状是过敏性紫癜患儿常见的临床表现,其常见的诱因为感染,皮疹反复发生≥4w及血FIB水平升高是过敏性紫癜患儿肾脏功能损害的重要危险因素。  相似文献   
8.

Background

Lyme disease is the number one arthropod-transmitted disease in the US, and one of the diagnostic criteria for the illness is development of an erythematous bull's-eye rash around a tick bite that may expand over time, hence the term erythema migrans. However, there are other erythema migrans-like rashes, such as those from a condition known as southern tick-associated rash illness. This article describes a patient with an erythema migrans-like lesion similar to that associated with Lyme disease, resulting from a bite by a nymphal-stage lone star tick, Amblyomma americanum.

Methods

A tick removed from the center of an erythema migrans-like lesion in a patient was identified to species and then submitted to the Centers for Disease Control and Prevention for testing for the agent of Lyme disease, Borrelia burgdorferi. The patient was evaluated by an internist 7 weeks later. After another 3 weeks, the patient's blood was tested serologically for Lyme disease by American Esoteric Laboratories, Memphis, Tenn.

Results

Both the tick and human blood sample from this patient were negative for evidence of Lyme disease. Clinically, other than the erythema migrans-like lesion, the patient displayed no signs or symptoms consistent with Lyme disease.

Conclusions

This case presents clinical, serological, and molecular evidence that erythema migrans lesions may occur after tick bites in patients and that these lesions may not be due to infection with the agent of Lyme disease.  相似文献   
9.
Zika virus infection should be suspected in travelers or immigrants with the signs or symptoms of a viral infection (rash, fever, joint pains, conjunctivitis, headache, etc.) and a compatible epidemiological history. Although cutaneous manifestations are among the most common clinical signs of Zika, they are not specific and very few images are available. We present 3 patients (2 travelers and 1 immigrant) in whom a rash was the presenting manifestation of Zika virus infection. Prompt diagnosis optimizes outcomes in these patients, improves the management of severe disease, and minimizes the risk of local transmission by Aedes albopictus, now a potential local vector for the virus due to its presence in areas along Spain's Mediterranean coast.  相似文献   
10.
AIM:To determine the factors affecting mortality in patients who developed graft-versus-host disease (GvH) after liver transplantation (LT) METHODS:We performed a review of studies of GvH following LT published in the English literature and accessed the PubMed, Medline, EBSCO, EMBASE, and Google Scholar databases Using relevant search phrases, 88 articles were identified. Of these, 61 articles containing most of the study parameters were considered eligible for the study. Risk factors were first examined using a univariate Kaplan-Meier model, and variables with a significant association (P 0 05) were then subjected to multivariate analyses using a Cox proportional-hazards model RESULTS:The 61 articles reported 87 patients, 58 male and 29 female, mean age, 40.4 ± 15.5 years (range:8 mo to 74 years), who met the inclusion criteria for the present study. Deaths occurred in 59 (67.8%) patients, whereas 28 (32.2%) survived after a mean follow-up period of 280.8 ± 316.2 d (range:27-2285 d). Among the most frequent symptoms were rash (94.2%), fever (66.6%), diarrhea (54%), and pancytopenia (54%). Theaverage time period between LT and first symptom onset was 60.6 ± 190.1 d (range: 2-1865 d). The Kaplan-Meier analysis revealed that pancytopenia (42.8% vs 59.3%,P = 0.03), diarrhea (39.2%vs 61.0%,P = 0 04), age difference between the recipient and the donor (14.6 ± 3.1 yearsvs 22.6 ± 2.7 years,P 0.0001), and time from first symptom occurrence to diagnosis or treatment (13.3 ± 2.6 mo vs 15.0 ± 2.3 mo, P 0.0001) were significant factors affecting mortality, whereas age, sex, presence of rash and fever, use of immunosuppressive agents, acute rejection before GvH , etiological causes, time of onset, and donor type were not associated with mortality risk The Cox proportional-hazards model, determined that an age difference between the recipient and donor was an independent risk factor (P = 0 03; hazard ratio, 7.395, 95% confidence interval, 1.2-46.7). CONCLUSION:This study showed that an age difference between the recipient and donor is an independent risk factor for mortality in patients who develop GvH after LT.  相似文献   
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