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1.
[目的] 总结全国名中医范永升教授运用青蒿治疗系统性红斑狼疮(systemic lupus erythematosus,SLE)的临床经验,提高对SLE的认识。[方法] 通过跟师学习,收集范教授诊治的SLE患者的临床资料,以及整理医案、查询相关文献,回顾分析范教授在SLE的不同阶段运用青蒿及并配伍相关药物的临床经验,并以验案佐证。[结果] 范教授通过辨证论治,以青蒿之清热解毒,治疗SLE轻型阴虚兼有热毒证;以青蒿之透邪滋阴,治疗SLE轻型余邪内伏证;以青蒿之清胆理气,治疗SLE重型肝郁血瘀证。所举病案中分别以解毒祛瘀滋阴方及蒿芩清胆汤治疗轻型及重型SLE,治疗后患者症状改善,SLE疾病活动(systemic lupus erythematosus disease activity index,SLEDAI)评分降低。[结论] 范教授针对SLE的不同阶段,运用青蒿清透虚热、凉血除蒸、解暑截疟,并配伍相关药物,疗效显著,其经验值得推广学习。  相似文献   
2.
[目的] 总结全国名中医范永升教授治疗白塞综合征的临床经验。[方法] 通过跟师临证、整理医案及相关文献等,总结范永升教授治疗白塞综合征的主要思想和处方用药,并举临床验案两则加以佐证。[结果] 范永升教授认为白塞综合征的基本病机为湿热内壅,治疗时应以利湿清热为大法,并需进一步分清湿热所在的位置。根据湿热所犯部位不同,可分为脾胃湿热上犯、肝胆湿热化火及下焦湿热流连三种类型,灵活应用甘草泻心汤、龙胆泻肝汤、四妙丸等方药,疗效显著。两则医案患者均表现出湿热内壅的症状,分别属于脾胃湿热上犯证、肝胆湿热化火证,以甘草泻心汤及龙胆泻肝汤为主方治疗,均取得较满意的疗效。[结论] 范永升教授把握白塞综合征湿热内壅的基本病机,灵活选用利湿清热方药,分病位治之,疗效显著,其经验可供参考借鉴。  相似文献   
3.

Background

Intramedullary nailing is considered a “gold standard” for treatment of tibial shaft fractures. However, some types of fractures are typically considered as “difficult for nailing”. This group includes the periarticular fractures, fractures of both bones at the same level, comminuted and segmental fractures of the tibia. Fixator-assisted nailing (FAN) is an effective method treatment of these types of fractures. The main requirements for the ideal reduction device are an ease of its installation and an ability of multiplanar fracture reduction. Fixator-assisted nailing (FAN) with the use of two perpendicular to each other monolateral tubular frames perfectly meets these requirements. In this study we present this new surgical technique and the analysis of first 30 cases.

Methods

A prospective analysis was conducted for 30 patients with “difficult for nailing” tibial fractures treated with fixator-assisted nailing in our institution between September 1st, 2017, and March 1st, 2018. The duration of surgery and its different stages, the time of fluoroscopy, difficulties encountered during surgery, were analyzed. Clinical and radiological methods were used to evaluated reduction quality.

Results

In all 30 cases the acceptable reduction was achieved. The mean duration of the surgical procedure was 73.7?±?3?min. The mean duration of fluoroscopy 85.9?±?4.8?s. In 7 cases we faced with technical difficulties, which were successfully addressed.

Conclusion

The described technique of FAN is an effective method for the treatment of “difficult for nailing” tibial fractures. Future multi-centered studies with a larger number of patients are needed to validate our results.  相似文献   
4.
[目的]总结范永升教授运用涤痰开窍法治疗系统性红斑狼疮脑病(systemic lupus erythematosus encephalopathy,SLEE)的经验。[方法]通过阅读文献,跟师临诊,收集病案,从病因病机、治法治则探讨范永升教授运用涤痰开窍法治疗系统性红斑狼疮脑病的临证经验,对其遣方用药规律予以总结分析,并附临床医案以佐证。[结果]范永升教授认为狼疮脑病常与痰瘀互结、脑窍痹阻机制有关,临证多用化痰开窍、平肝熄风的方法,常选用涤痰汤、牵正散、天麻钩藤饮等加减进行治疗,常用的药物有石菖蒲、胆南星、钩藤、半夏、竹茹、郁金、远志等。所附病案显示狼疮脑病患者呈明显的痰湿、瘀阻、脑窍受损之神志异常等症状,范永升教授以涤痰开窍法为先,参以息风通络、通腑泄热等为治疗法则,疗效颇好。[结论]范永升教授认为系统性红斑狼疮脑病以痰浊郁闭为标,根据中医"急则治其标"的治疗原则,临床用涤痰开窍法治疗系统性红斑狼疮脑病发作,具有一定疗效,值得学习和推广。  相似文献   
5.
目的:总结樊瑞红教授通补并用法治疗慢性心力衰竭经验,观察其创立的通补并用的通补心宝汤治疗慢性心力衰竭的临床疗效和安全性。方法:将76例慢性心力衰竭患者随机分为治疗组38例和对照组38例。对照组予常规西药治疗,治疗组在此基础上加服通补心宝汤,28 d为1个疗程。观察治疗前后两组心功能、中医证候积分、射血分数,6 min步行试验,N末端脑钠肽(NT-pro BNP)情况。同时记录治疗期间不良反应。结果:治疗组心功能疗效总有效率为78.95%,优于对照组的60.53%(P0.05)。治疗组中医证候疗效总有效率为81.58%,明显优于对照组的55.26%(P0.01)。两组患者射血分数,6 min步行距离,NT-pro BNP比较,治疗组疗效优于对照组(P0.05)。两组均无严重不良反应发生。结论:通补并用法治疗慢性心力衰竭效果较好,通补心宝汤结合西医治疗慢性心力衰竭疗效优于单纯西医治疗。  相似文献   
6.
7.
The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defective (Fan1nd/nd) mice develop a mild form of KIN. The karyomegalic nuclei from Fan1nd/nd kidneys are polyploid, and fibroblasts from Fan1nd/nd mice become polyploid upon ICL induction, suggesting that defective ICL repair causes karyomegaly. Thus, Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy, a role that we show is not shared by the Fanconi anemia pathway or the Slx4–Slx1 nuclease also involved in ICL repair.  相似文献   
8.
近年来学界关于范当世的研究大致涉及其生平、思想与性格、诗学主张和文章特色、诗作研究四个方面。了解研究的概貌和现状,不仅对进一步深化和拓展范当世研究有一定意义,而且或能有助于考察目前面目尚显模糊的晚清文坛。  相似文献   
9.
Fangchinoline (FAN; a plant alkaloid isolated from Stephania tetrandrae) is a nonspecific Ca(2+) channel blocker. The objective of the present study was to investigate the effect of FAN on the growth factor-induced proliferation of primary cultured rat aortic smooth muscle cells (RASMCs). FAN significantly inhibited both 5% fetal bovine serum (FBS)- and 50ng/mL platelet-derived growth factor (PDGF)-BB-induced proliferation, [3H]thymidine incorporation into DNA and phosphorylation of extracellular signal-regulated kinase 1/2. In accordance with these findings, FAN revealed blocking of the FBS-inducible progression through G(0)/G(1) to S phase of the cell cycle in synchronized cells and caused a 62% decrease in the early elevation of c-fos expression induced after 5% FBS addition. Furthermore, significant antiproliferative activity of FAN is observed at concentrations below those required to achieve significant inhibition of Ca(2+) channels by FAN. These results suggest that FAN reduced both FBS- and PDGF-BB-induced RASMCs proliferation by perturbing cell cycle progression. This antiproliferative effect of FAN is dependent on the MAP kinase pathway, but cannot be limited to its Ca(2+) modulation.  相似文献   
10.
[目的] 总结首届全国名中医范永升教授治疗全身型幼年特发性关节炎的学术经验。[方法] 通过跟诊学习,整理分析典型病案,并参阅相关文献,结合范永升教授的著作及临证所述,从病因病机、治疗思路两个层面总结归纳范永升教授治疗全身型幼年特发性关节炎的学术经验,并附验案一则加以佐证。[结果] 范永升教授认为,全身型幼年特发性关节炎发病过程与温病卫气营血转变规律相似,致病特点与伏邪温病也有相似之处,多因正气亏虚于内,加之感受外邪,伏藏于里,伺机而发,或外邪引动而发。临床应用火郁发之,透解伏邪;顾护正气,攻伐有度;续贯治疗,增效减毒等治疗思路治疗本病,取得了满意的临床疗效。验案中患者就诊初期表现为邪伏阴分、气营两燔,治以清解和营、祛风通络;药后疹消热退,伏邪出阳,枢机不利,治以和解枢机、清透郁热;待邪气渐去,正气已衰,遂予以疏解透热,佐以和胃健脾。整个治疗过程中辛透伏邪贯穿始终,同时体现了范永升教授用药灵活、顾护正气的治疗思路。[结论] 范永升教授以伏邪温病理论为基础,从卫气营血辨治全身型幼年特发性关节炎临床收效甚佳,其学术经验值得借鉴和推广。  相似文献   
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