全文获取类型
收费全文 | 109433篇 |
免费 | 10463篇 |
国内免费 | 4799篇 |
专业分类
耳鼻咽喉 | 786篇 |
儿科学 | 4700篇 |
妇产科学 | 1374篇 |
基础医学 | 10151篇 |
口腔科学 | 1602篇 |
临床医学 | 10042篇 |
内科学 | 15044篇 |
皮肤病学 | 1282篇 |
神经病学 | 3416篇 |
特种医学 | 4487篇 |
外国民族医学 | 57篇 |
外科学 | 27961篇 |
综合类 | 16164篇 |
现状与发展 | 33篇 |
一般理论 | 2篇 |
预防医学 | 2419篇 |
眼科学 | 1822篇 |
药学 | 5764篇 |
51篇 | |
中国医学 | 2103篇 |
肿瘤学 | 15435篇 |
出版年
2024年 | 76篇 |
2023年 | 1518篇 |
2022年 | 2080篇 |
2021年 | 3944篇 |
2020年 | 3816篇 |
2019年 | 3817篇 |
2018年 | 3755篇 |
2017年 | 3820篇 |
2016年 | 4014篇 |
2015年 | 4129篇 |
2014年 | 6575篇 |
2013年 | 7103篇 |
2012年 | 5815篇 |
2011年 | 6759篇 |
2010年 | 5779篇 |
2009年 | 5896篇 |
2008年 | 5994篇 |
2007年 | 6434篇 |
2006年 | 6139篇 |
2005年 | 5414篇 |
2004年 | 4554篇 |
2003年 | 3832篇 |
2002年 | 3336篇 |
2001年 | 2894篇 |
2000年 | 2401篇 |
1999年 | 1995篇 |
1998年 | 1687篇 |
1997年 | 1488篇 |
1996年 | 1313篇 |
1995年 | 1255篇 |
1994年 | 1205篇 |
1993年 | 811篇 |
1992年 | 837篇 |
1991年 | 640篇 |
1990年 | 459篇 |
1989年 | 447篇 |
1988年 | 444篇 |
1987年 | 335篇 |
1986年 | 260篇 |
1985年 | 320篇 |
1984年 | 271篇 |
1983年 | 159篇 |
1982年 | 208篇 |
1981年 | 174篇 |
1980年 | 119篇 |
1979年 | 109篇 |
1978年 | 86篇 |
1977年 | 65篇 |
1976年 | 53篇 |
1975年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
1.
《The Journal of thoracic and cardiovascular surgery》2023,165(1):301-326
ObjectiveThe use of mechanical circulatory support (MCS) in lung transplantation has been steadily increasing over the prior decade, with evolving strategies for incorporating support in the preoperative, intraoperative, and postoperative settings. There is significant practice variability in the use of these techniques, however, and relatively limited data to help establish institutional protocols. The objective of the AATS Clinical Practice Standards Committee (CPSC) expert panel was to review the existing literature and establish recommendations about the use of MCS before, during, and after lung transplantation.MethodsThe AATS CPSC assembled an expert panel of 16 lung transplantation physicians who developed a consensus document of recommendations. The panel was broken into subgroups focused on preoperative, intraoperative, and postoperative support, and each subgroup performed a focused literature review. These subgroups formulated recommendation statements for each subtopic, which were evaluated by the entire group. The statements were then developed via discussion among the panel and refined until consensus was achieved on each statement.ResultsThe expert panel achieved consensus on 36 recommendations for how and when to use MCS in lung transplantation. These recommendations included the use of veno-venous extracorporeal membrane oxygenation (ECMO) as a bridging strategy in the preoperative setting, a preference for central veno-arterial ECMO over traditional cardiopulmonary bypass during the transplantation procedure, and the benefit of supporting selected patients with MCS postoperatively.ConclusionsAchieving optimal results in lung transplantation requires the use of a wide range of strategies. MCS provides an important mechanism for helping these critically ill patients through the peritransplantation period. Despite the complex nature of the decision making process in the treatment of these patients, the expert panel was able to achieve consensus on 36 recommendations. These recommendations should provide guidance for professionals involved in the care of end-stage lung disease patients considered for transplantation. 相似文献
2.
3.
4.
5.
Biaoming Xu Yu Chen Mingjing Peng Jin Hai Zheng Chaohui Zuo 《International journal of cancer. Journal international du cancer》2023,152(2):110-122
Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes derived from PDAC (PDAC-exosomes) promote PDAC development and metastasis. Exosomes are nanoscale vesicles secreted by most cells, which can carry biologically active molecules and mediate communication and cargo transportation among cells. Recent studies have focused on transforming exosomes into good drug delivery systems (DDSs) to improve the clinical treatment of PDAC. This review considers PDAC as the main research object to introduce the role of PDAC-exosomes in PDAC development and metastasis. This review focuses on the following two themes: (a) the great potential of PDAC-exosomes as new diagnostic markers for PDAC, and (b) the transformation of exosomes into potential DDSs. 相似文献
6.
Yuka Ikeda Kurumi Taniguchi Haruka Sawamura Ai Tsuji Satoru Matsuda 《World journal of gastroenterology : WJG》2022,28(31):4471-4474
Irritable bowel syndrome (IBS) is an important health care concern. Alterations in the microbiota of the gut-brain axis may be linked to the pathophysiology of IBS. Some dietary intake could contribute to produce various metabolites including D-amino acids by the fermentation by the gut microbiota. D-amino acids are the enantiomeric counterparts of L-amino acids, in general, which could play key roles in cellular physiological processes against various oxidative stresses. Therefore, the presence of D-amino acids has been shown to be linked to the protection of several organs in the body. In particular, the gut microbiota could play significant roles in the stability of emotion via the action of D-amino acids. Here, we would like to shed light on the roles of D-amino acids, which could be used for the treatment of IBS. 相似文献
7.
8.
9.
目的 观察超声引导下关节腔内注射重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白(益赛普)治疗血友病性关节病(HA)的价值。方法 回顾性分析32例接受超声引导下穿刺关节腔注射益赛普的HA患者,对比观察治疗前及治疗后1个月血友病关节健康评分(HJHS)、视觉模拟评分(VAS),以及超声所示目标关节增生滑膜厚度、血流信号、Melchiorre及中国早期血友病性关节病超声检测(HEAD-US-C)评分,评估其治疗价值。结果 对32例均成功完成超声引导下穿刺关节腔及腔内注射益赛普,共对18例膝关节、7例肘关节及7例踝关节进行治疗。术后未出现感染、出血等并发症。治疗后1个月,目标关节HJHS、VAS、Melchiorre评分、HEAD-US-C评分及增生滑膜最大厚度、平均厚度、血流信号均低于治疗前(P均<0.01)。结论 超声引导下关节腔内注射益赛普治疗HA安全、有效。 相似文献
10.