首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3838篇
  免费   186篇
  国内免费   32篇
耳鼻咽喉   41篇
儿科学   165篇
妇产科学   122篇
基础医学   237篇
口腔科学   58篇
临床医学   309篇
内科学   462篇
皮肤病学   44篇
神经病学   349篇
特种医学   85篇
外科学   321篇
综合类   440篇
一般理论   1篇
预防医学   792篇
眼科学   21篇
药学   312篇
  2篇
中国医学   108篇
肿瘤学   187篇
  2023年   88篇
  2022年   147篇
  2021年   174篇
  2020年   171篇
  2019年   169篇
  2018年   147篇
  2017年   140篇
  2016年   174篇
  2015年   137篇
  2014年   322篇
  2013年   309篇
  2012年   240篇
  2011年   269篇
  2010年   244篇
  2009年   185篇
  2008年   183篇
  2007年   172篇
  2006年   112篇
  2005年   91篇
  2004年   67篇
  2003年   71篇
  2002年   48篇
  2001年   41篇
  2000年   42篇
  1999年   24篇
  1998年   34篇
  1997年   20篇
  1996年   14篇
  1995年   18篇
  1994年   24篇
  1993年   6篇
  1992年   13篇
  1991年   14篇
  1990年   11篇
  1989年   11篇
  1988年   10篇
  1987年   6篇
  1986年   6篇
  1985年   11篇
  1984年   11篇
  1983年   11篇
  1982年   7篇
  1981年   10篇
  1980年   11篇
  1979年   8篇
  1978年   6篇
  1976年   5篇
  1975年   3篇
  1973年   7篇
  1971年   6篇
排序方式: 共有4056条查询结果,搜索用时 15 毫秒
1.
目的:探讨个体怀旧疗法对年轻晚期癌症患者预期性悲伤和生活质量的干预效果。方法:选择2019年10月至2020年7月在某肿瘤专科医院就诊的90例年轻晚期癌症患者配偶为研究对象,随机分为对照组和观察组各45例。对照组给予常规健康教育和指导,观察组在对照组的基础上联合个体怀旧疗法。采用中文版预期性悲伤量表、癌症患者照顾者生活质量调查表进行干预效果评价。结果:干预后观察组除失去的感觉维度外,预期性悲伤总分及其他各维度得分均低于对照组,观察组身体健康、心理健康维度得分和生活质量总分高于对照组,差异有统计学意义(P<0.05)。结论:个体怀旧疗法可降低年轻晚期癌症患者配偶的预期性悲伤水平,提高其生活质量。  相似文献   
2.
Background and aimsThe extent to which dietary patterns influence the risk of abnormal blood lipids throughout young adulthood remains unclear. The aim was to investigate whether early young adulthood dietary patterns predict the risk of abnormal blood lipids during later young adulthood.Methods and resultsWe used data from a long running birth cohort study in Australia. Western dietary pattern rich in meats, processed foods and high-fat dairy products and prudent pattern rich in fruit, vegetables, fish, nuts, whole grains and low-fat dairy products were derived using principal component analysis at the 21-year follow-up from dietary data obtained using a food frequency questionnaire. After 9-years, fasting blood samples of all participants were collected and their total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterols and triglyceride (TG) levels were measured. Abnormal blood lipids were based on clinical cut-offs for total, LDL and HDL cholesterols, and TG and relative distributions for total:HDL and TG:HDL cholesterols ratios. Log-binomial models were used to estimate risk of each outcome in relation to dietary patterns. Greater adherence to the Western pattern predicted increased risks of high LDL (RR: 1.47; 95%CI: 1.06, 2.03) and TG (1.90; 1.25, 2.86), and high ratios of total:HDL (1.48; 1.00, 2.19) and TG:HDL (1.78; 1.18, 2.70) cholesterols in fully adjusted models. Conversely, a prudent pattern predicted reduced risks of low HDL (0.58; 0.42, 0.78) and high TG (0.66; 0.47, 0.92) and high total:HDL (0.71; 0.51, 0.98) and TG:HDL (0.61; 0.45, 0.84) cholesterols ratios.ConclusionThis is the first prospective study to show greater adherence to unhealthy Western diet predicted increased risks of abnormal blood lipids, whereas healthy prudent diet predicted lower such risks in young adults. Addressing diets in early course may improve cardiovascular health of young adults.  相似文献   
3.
Background and purposeType 1 diabetes (T1D), type 2 diabetes, and prediabetes are increasing in incidence. Adolescents and young adults with diabetes experience psychosocial comorbidities at an increased incidence. As such, exploring interventions that can improve psychosocial and glycemic outcomes are needed. The purpose of this integrative review is to examine and synthesize the literature on mindfulness in adolescents and young adults with type 1 or type 2 diabetes or prediabetes.MethodsFour databases were searched during May 2021. Included studies were published between 2000 and 2021, evaluated adolescents and young adults, diagnosed with type 1 or type 2 diabetes or prediabetes. Studies were excluded if they were not in English; not original research; evaluated complementary/alternative therapies as a group. To assess for risk of bias, the National Institutes of Health quality assessment tools and the Cochrane Collaboration's tool were utilized. Whittemore and Knafl's (2005) method for conducting an integrative review was utilized to synthesize results.ResultsWe identified 137 articles in our initial search and 74 articles remained after removing for duplicates. Ten articles were included in the review, with 5 including adolescents and young adults with T1D and 5 including adolescents and young adults with prediabetes. No studies evaluated mindfulness in adolescents and young adults with type 2 diabetes.ConclusionMindfulness is an acceptable intervention in adolescents and young adults with T1D and prediabetes, resulting in positive psychosocial and glycemic outcomes. There were issues with feasibility of the intervention and mobile health technology delivery methods should be evaluated.  相似文献   
4.
Background and aimsCurrent strategies to reduce cardiovascular disease (CVD) risk in young adults are largely limited to those at extremes of risk. In cohort studies we have shown cluster analysis identified a large sub-group of adolescents with multiple risk factors. This study examined if individuals classified at ‘high-risk’ by cluster analysis could also be identified by their Framingham risk scores.Methods and resultsRaine Study data at 17- (n = 1048) and 20-years (n = 1120) identified high- and low-risk groups by cluster analysis using continuous measures of systolic BP, BMI, triglycerides and insulin resistance. We assessed:- CVD risk at 20-years using the Framingham 30 yr-risk-score in the high- and low-risk clusters, and cluster stability from adolescence to adulthood.Cluster analysis at 17- and 20-years identified a high-risk group comprising, 17.9% and 21.3%, respectively of the cohort. In contrast, only 1.2% and 3.4%, respectively, met the metabolic syndrome criteria, all of whom were within the high-risk cluster. Compared with the low-risk cluster, Framingham scores of the high-risk cluster were elevated in males (9.4%; 99%CI 8.3, 10.6 vs 6.0%; 99%CI 5.7, 6.2) and females (4.9%; 99%CI 4.4, 5.4 vs 3.2%; 99%CI 3.0, 3.3) (both P < 0.0001). A score >8 for males and >4 for females identified those at high CVD risk with 99% confidence.ConclusionCluster analysis using multiple risk factors identified ~20% of young adults at high CVD risk. Application of our Framingham 30 yr-risk cut-offs to individuals allows identification of more young people with multiple risk factors for CVD than conventional metabolic syndrome criteria.  相似文献   
5.
  目的  了解2010—2019年中国经同性传播感染HIV的18~24岁男性青年学生HIV感染者时空分布特征及变化趋势,为开展青年学生艾滋病防控措施提供参考。  方法  以18~24岁经同性传播感染HIV的男性青年学生为研究对象,通过ArcGIS 10.3软件进行分布描述、局域热点分析,并通过SaTScan 9.6软件进行时空扫描分析,探索聚集区及聚集时段。  结果  2010—2019年共报告经同性传播感染的18~24岁男性青年学生HIV感染者16 918例。全国18~24岁青年学生报告病例数由2010年的488例增长至2019年的2 481例,其中重庆市、四川省和北京市等地区报告数较高。经同性传播感染HIV的18~24岁男性青年学生在同期同年龄段男性人口中占比超过万分之一的地市个数由2010年的1个增加至2019年的17个。2010—2019年共有16个聚集区;第一类聚集区涵盖重庆市、成都市和西安市等地区,聚集时段为2015—2019年(RR=2.66, P < 0.001)。  结论  中国经同性传播感染的18~24岁男性青年学生HIV感染者具有一定时空聚集性,应在热点区域、聚集区开展有针对性的防控工作,降低HIV在青年学生中的流行。  相似文献   
6.
ObjectivesCancer can have long-term biopsychological impacts for young people that persist for years. To promote adjustment, it is essential to understand how young people cope, yet this is relatively understudied.MethodsThis study explored the coping strategies using semi-structured interviews with 16 young people with cancer aged 15–24 years. Eligible participants were diagnosed within the previous 24 months and recruited through Australian Youth Cancer Services. Transcribed interviews were analysed using content analysis.ResultsCoping strategies included: seeking support; controlling the focus; avoiding negatives and staying positive; meaning making and; changes with time. During treatment, seeking support, focussing on the present, distraction and avoidance were commonly applied. Following treatment, planning for the future, avoidance of re-traumatising situations and meaning making were used.ConclusionFindings support the concept of coping as a dynamic process where different strategies are used depending on the stressor, available resources and previous experiences.Practice ImplicationsComprehensive, developmentally appropriate psychosocial assessments, open communication, education and information provision, as well as appropriate referral for support are essential, particularly for young cancer survivors identified at risk.  相似文献   
7.
目的探讨年轻的闭角型青光眼住院患者的病种构成, 并比较原发性闭角型青光眼(PACG)与继发性闭角型青光眼(SACG)的临床特征。方法回顾性病例系列研究。连续收集2012年1月至2019年12月于中山大学中山眼科中心就诊的发病年龄≤40岁的闭角型青光眼住院患者资料, 记录患者入院诊断、性别、发病年龄, 收集患者常规眼科检查及A型超声波测定、超声生物显微镜、相干光层析成像术及视野检查的结果。分析PACG与SACG所占比例、病种构成, 比较两类患者的发病年龄、视力、视野、眼球生物学结构参数及初诊误诊率。非正态分布资料以M(Q1, Q3)表示。统计学比较采用Mann-WhitneyU检验、χ2检验及独立样本t检验。结果共纳入243例(243只眼)患者, 发病年龄(28±9)岁;男性与女性比例为1∶1.79;其中PACG患者93例(38.3%), SACG患者150例(61.7%)。PACG患者年龄[34(28, 38)岁]及男性比例[22.6%(21/93)]与SACG患者[28(19, 34)岁, 44.0%(66/150)]比较, 差异均有统计学意义(Z=-5.34, χ2=11.46;均...  相似文献   
8.
9.
目的 探讨应用剪切波弹性成像(SWE)技术联合多参数评估肝硬化患者并发食管静脉曲张(EV)的价值。方法 2018年3月~2021年3月我院收治的肝硬化患者89例,接受胃镜检查,了解EV发生情况,采用SWE技术检测脾脏杨氏模量最大值(Emax)和杨氏模量平均值(Emean),使用彩色多普勒超声检测肝脏门静脉直径(PVD)、脾脏厚径(ST)、脾脏长径(SD)和脾静脉直径(SVD),应用受试者工作特征曲线下面积(AUC)分析各参数诊断肝硬化患者并发EV的效能。结果 经胃镜检查发现,本组89例肝硬化患者并发EV者53例;EV组在Child-Pugh分级、白蛋白、凝血酶原时间国际标准化比值、血小板计数和有腹水的比率等方面与非EV组比,均存在显著性差异(P<0.05);EV组Emax和Emean分别为(55.9±10.5)kPa和(38.9±9.2)kPa,显著大于非EV组【分别为(45.2±7.3)kPa和(29.3±6.7)kPa,P<0.05】,PVD、ST、SD和SVD分别为(13.6±2.1)mm、(48.0±9.4)mm、(149.1±27.1)mm和(10.1±1.9)mm,均显著大于非EV组【分别为(11.5±1.8)mm、(36.9±8.7)mm、(119.8±24.9)mm和(7.8±1.7)mm,P<0.05】;分别以Emax、Emean、PVD、ST、SD和SVD为53.2 kPa、33.6 kPa、11.9 mm、43.8 mm、136.5 mm和8.9 mm为截断点,其诊断肝硬化并发EV的AUC分别为0.84、0.83、0.73、0.80、0.67和0.82,诊断的敏感度和特异度分别为66.0%和88.9%、75.5%和77.8%、79.3%和61.1%、77.4%和72.2%、58.5%和69.4%、77.4%和80.6%。结论 应用SWE技术测量脾脏Emax和Emean可用于肝硬化患者并发EV的诊断,对帮助判断病情,及时予以预防处理。  相似文献   
10.
Background and aims(Poly)phenols might contribute to prevent cardiovascular disease, but limited prospective studies exist among adolescents. This study aimed to evaluate within-subject longitudinal changes in (poly)phenols intakes and food group contributors while also exploring the association with metabolic syndrome risk (MetS) during 10 years of follow up in European adolescents becoming young adults.Methods and resultsIn 164 participants (58% girls, 13-18 y at baseline) from Ghent, Zaragoza and Lille, longitudinal data (2006–2016) on (poly)phenol intake was retrieved via 2 or 3 24 h recalls. Linear and logistic longitudinal regression tested the association of (poly)phenols intake (total and classes) with Mets risk or its components (waist-height-ratio, HDL cholesterol, LDL cholesterol, triglycerides, blood pressure and insulin resistance index), adjusted for age, sex, country and other nutrient intakes. The total (poly)phenols intake was 421 ± 107 mg/day (192 mg/1000 kcal/day) at baseline, while 610 ± 101 mg/day (311 mg/1000 kcal/day) at follow-up. The three major food sources for (poly)phenols were ‘chocolate’, ‘fruit and vegetable juices’, ‘cakes and biscuits’ during adolescence and ‘coffee’, ‘tea’ and ‘chocolate’ during adulthood. Phenolic acid intake was associated with less LDL increase over time, while stilbene intake with a steeper increase in triglycerides over time.ConclusionsDifferences in major (poly)phenols contributors over time were partially explained by age-specific dietary changes like increased coffee and tea during adulthood. Some significant (poly)phenols-MetS associations might argue for nutrition-based disease prevention during adolescence, especially since adolescents had low (poly)phenols intake.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号