Dynamic stability in runners with and without plantar fasciitis

BackgroundPlantar fasciitis (PF) is a common overuse injury experienced by runners. PF may decrease the ability of the plantar fascia to create tension and reduce stability of the foot. Stability of the foot is necessary for whole-body dynamic stability during running which consists of cyclical periods of single leg stance. Given that a major risk factor for running-related injury is previous injury, evaluating dynamic stability in runners with PF, runners with resolved PF, and healthy runners may elucidate differences between these individuals and clarify risk for secondary injury in these groups.Research questionIs dynamic stability reduced in runners with PF and runners with resolved PF compared to healthy runners?MethodsThirty runners were recruited for this retrospective comparative study based on mileage and injury status: current PF (PF), resolved PF (RPF), or healthy (CON). Kinematic and kinetic data were collected during running and dynamic stability was determined by time-to-contact (TtC) analysis for early, mid, and late stance to the anterior, posterior, medial, and lateral boundary of the foot. Dynamic stability was compared between groups one-way ANOVAs (α = 0.05) and Tukey post-hoc tests conducted when appropriate. Cohen’s d effect sizes (d) were reported for all TtC comparisons (small = 0.20, medium = 0.50, large = 0.80).ResultsTtC values were shorter in PF compared to the other groups to all boundaries during mid-stance. TtC was significantly greater in PF compared to RPF to the anterior boundary during late stance.SignificanceShorter TtC observed in PF compared to the other groups during midstance may indicate reduced dynamic stability during the most stable portion of running which may lead to increased injury risk.     

Serum growth factor stability in different eye drop packaging systems during storage

Serum eye drops (SED) have shown beneficial effects in patients suffering from dry eye syndrome and are manufactured for an increasing number of patients in Australia every year. Previous studies have examined the stability of serum growth factors during storage in either experimental vessels not used as the final packaging system or in eye drop bottles. To ensure the quality and safety of SED product manufactured in Australia, the stability of growth factors in serum packaged into two different systems during storage at different temperatures was examined. Healthy blood donors provided a whole blood donation, from which serum was prepared, diluted to 20% and dispensed into either a tube or a vial packaging system. The stability of growth factors, fibronectin and total protein in tube segments was comparable to matched vials samples during storage at −30 °C, 4 °C, 22 °C and 37 °C, with the exception of EGF and fibronectin in 20% SED stored in tube segments, which were more sensitive to storage conditions at 4 °C and 22 °C when compared to vials. Additionally, the growth factor, fibronectin and total protein concentration in both tube segments and vials was stable during storage at −30 °C for at least 9 months. This study highlights the impact of different manufacturing procedures on serum growth factor stability during storage.     

感咳清颗粒的鉴别及稳定性研究

目的 介绍感咳清颗粒的制备、薄层鉴别方法并预测其保质期。方法 以薄荷、黄芩、防风等为原料制备感咳清颗粒剂；参照《中国药典》的方法对该制剂的主药进行薄层定性鉴别；用加速实验法以黄芩苷含量为指标预测了该制剂的稳定性。结果 感咳清颗粒定性鉴别的专属性强；高温加速实验法测得常温下复方制剂以黄芩苷含量为指标的保质期为2年半。结论 该制剂质量稳定可控。     

前循环缺血性卒中老年患者颈动脉斑块及其稳定性与血流壁切应力的关系

目的通过探讨前循环缺血性卒中老年患者颈总动脉分叉处血流壁切应力的水平分析其在颈动脉斑块形成过程中的影响。方法本研究选择前循环缺血性卒中老年患者,应用经皮血管彩超测量颈动脉斑块及其稳定性以及对研究对象测量患侧颈动脉血流速度、血管内径和血液粘滞度,通过公式计算血流壁切应力。结果无斑块组和有斑块组之间、高回声和低回声斑块组之间血流壁切应力均有显著性差异(P<0．01)。结论血流壁低切应力促进颈动脉斑块、尤其是不稳定斑块的形成。     

Cytoskeletal and muscle-like elements in cochlear hair cells

Summary Monospecific antibodies to actin and to tubulin were used as immunofluorescent probes to evaluate the distribution of microtubules and actin filaments in the organ of Corti in mouse and guinea pig. The results indicate that in cochlear receptor cells actin and actin filaments as well as tubulin and microtubules are integral cytoskeletal elements. The presence of actin suggests a possible contractile mechanism within the sensory cilia whereas tubulin is thought to play an important role in the stability of sensory cells. Both proteins are discussed to form structural elements required for the mechano-chemical coupling in hearing.

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Abbreviations ATP adenosin-tri-phosphate - SDS sodium-dodecyl-sulphate - PBS phosphate-buffered saline Dedicated to Professor Dr. A. Herrmann on the occasion of his 80th birthday     

双氯芬酸钠滴眼液稳定性研究

采用高效液相色谱法测定双氯芬酸钠滴眼液的含量，方法简便，准确，能将药与杂质峰完全分离。应用化学动力学原理以恒温加试验预测双氯芬酸钠滴眼液稳定性及有效期，室温下有效期ｔ＾２５℃０．９约为２．５７年，与留样观察结果相符。     

胸腰椎稳定性重建方法的改进

为了改进胸腰椎脱位的治疗方法，更好地重建脊柱稳定性，设计了一种新的脊柱固定器械，由滚花钉及连接板构成，并通过椎弓根进行的一种脊柱后路短节段固定方法，脊柱固定范围限制在两个椎体间。１９８９年～１９９５年，临床应用这种新器械矫正胸腰椎脱位１２例，经１～４年随访，畸形矫正满意，固定牢固。结果表明：该器械具有手术方法简单、固定牢固和手术创伤小等优点。认为，该项技术适用于胸腰椎稳定性的重建。     

头孢噻肟溶液稳定性研究

本文采用紫外分光光度法对 CTX 溶液的含量及稳定性进行了实验研究。结果表明:该方法简便可行,本品最大吸收峰在234nm(±1nm)处,CTX 溶液在 pH 3.7—8.0之间稳定,有效期为2.1天,与5%葡萄糖液、10%葡萄糖液、5%葡萄糖氯化钠液、林格氏液、0.9%NaCl 液配伍(25℃),在48小时内含量变化不大,可以联合应用。     

维生素B_(12)注射液稳定性的研究

作者用恒温加速试验法研究了维生素B_(12)注射液的稳定性。结果表明:该注射液的稳定性在pH值4.80左右较好,加络合剂可增加其稳定性,有效期为5年。     

白醋加碘酸钾不同含量稳定性的四年观察研究

目的 摸清碘酸钾加入白醋中不同含量的稳定性。方法 配成含碘50、100、200mg／L的碘醋，各按500ml装瓶，密封室温阴凉处放置备用。第一年每隔两个月，第二、三、四年每隔半年测定一次其碘含量。结果 50、100、200mg／L的碘醋一年碘保存率分别为：96.06％、97．76％、95.20％；二年碘保存率分别为：86．06％、92．42％、92.85％；三年碘保存率分别为：76.98％、87.52％、90.95％；四年碘保存率分别为：71．78％、83．26％、89．35％，感观上均没有变化。结论 碘醋第一年的稳定性顺序为：100、50、200mg/L，第二、三、四年的稳定性顺序为：200、100、50mg／L。证明白醋加碘酸钾是稳定可行的。