角茴香的生药学研究

报道了角茴香的生药学特征。结果表明：角茴香其根的结构特点为双子叶植物根的正常初生结构；茎的组织结构为双子叶植物茎的正常初生结构，具有油细胞、粘液细胞和草酸钙结晶，淀粉多为单粒，维管束为有限外韧型。叶为两面型，栅栏组织通过主脉，气孔为不定式。     

藏药五脉绿绒蒿中非生物碱成分

目的:研究藏药五脉绿绒蒿Meconopsis quintuplinervia的化学成分。方法:应用色谱技术分离纯化,用波谱学方法确定化合物结构。结果:从乙醇提取物中分离得到12个化合物,分别鉴定为:槲皮素-3-O-β-D-葡萄糖苷(Ⅰ),槲皮素-3-O-[β-D-半乳糖(1→6)]-β-D-葡萄糖苷(Ⅱ),山柰素-3-O-[β-D-葡萄糖(1→2)]-β-D-葡萄糖苷(Ⅲ),异鼠李黄素-3-O-[β-D-半乳糖苷(1→6)]-β-D-葡萄糖(Ⅳ),咖啡酸(Ⅴ),原儿茶酸(Ⅵ),对羟基肉桂酸(Ⅶ),2-(3,4-二羟苯基)-乙醇β-D-吡喃葡萄糖苷(Ⅷ),对羟基苯甲酸β-D-吡喃葡萄糖酯苷(Ⅸ),肉桂酸4-O-β-D-吡喃葡萄糖苷(Ⅹ),5,7-二羟基色原酮(Ⅺ),胡萝卜苷(Ⅻ)。结论:除Ⅵ和Ⅻ外,其余10个化合物均为首次从该属植物中发现。     

紫堇属藏药的化学与药理学研究进展

我国有紫堇属植物约298种,其中特有10组219种,广泛用于藏医藏药。紫堇属藏药主要用于感冒发烧、肝炎、水肿、胃炎、胆囊炎、高血压等多种疾病。其化学成分主要为异喹啉生物碱。现代药理学研究表明紫堇属植物对心血管系统、中枢神经系统、抗菌、镇痛、抗炎、保肝、抗氧化等,皆有明显的作用。该文对我国紫堇属藏药的种属、分布、化学成分、药理活性等进行系统综述,并对其相关研究现状和前景进行了展望,以期为紫堇属藏药的深入研究和开发利用提供参考。     

Cytotoxic constituents from the whole plant ofcorydalis pallida

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.     

Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.     

Alkaloids from Bocconia frutescens. and Biological Activity of their Extracts

Abstract

In Mexican traditional medicine, Bocconia frutescens. L. (Papaveraceae) is known as “gordolobo” or “llorasangre.” Natives use this plant to treat skin ulcer, dermatitis, and some respiratory tract infections. In this study, the aerial parts afforded the alkaloids dihydrochelerythrine, (±)-6-acetonyldihydrochelerythrine, (±)-6-acetonyldihydrosanguinarine, as well as β.-amyrine acetate and 2-decanol. The structures were determined by spectral methods including UV, IR, NMR and mass spectrometry. The antimicrobial activity of extracts and pure compounds was tested with Escherichia coli., Staphylococcus aureus., Pseudomonas aeruginosa., and Bacillus subtilis.. This study supports the use of B. frutescens. in traditional medicine.     

Cytotoxic isoquinoline alkaloids from the aerial parts ofCorydalis incisa

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.     

藏族医学药用罂粟科药材品种基原与标准整理

通过查阅藏族医药文献与相关标准，结合实地调查结果，对藏族医学（以下简称藏医学）药用的罂粟科植物的药材品种、基原及质量标准状况进行系统整理，为藏医学药用罂粟科植物的资源合理利用、品种整理及质量标准制定提供参考。结果表明，藏医学药用的罂粟科植物有6属约144种（含种下等级），主要为高原分布的种类，其中有17种为我国特有种，以紫堇属（97种7变种1亚种）和绿绒蒿属（27种1变种）的种类最多；约涉及20个药材品种，其中有关标准中收载有12个，涉及基原植物30种（含变种），部分药材的基原存在与其他科属植物交叉的情况。藏医学药用罂粟科植物药材多数为藏药特色品种，具有重要的资源开发利用潜力；多数药材品种存在“名称-基原”不规范、不同地区习用的基原种类差异较大、质量标准缺失或不完善的问题，有待结合现代药学研究开展其品种整理、质量标准制定工作。     

Two new quaternary protoberberine alkaloids from Corydalis yanhusuo

Two new quaternary protoberberine alkaloids, namely corydayanine (1) and yanhusuine (2), were isolated from the tubers of Corydalis yanhusuo. On the basis of extensive chemical and spectroscopic evidences, especially 1D and 2D NMR and HRMS experiments, their structures were elucidated as 5,6-dihydro-3,9-dihydroxy-2,10-dimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid and 5,6-dihydro-12-hydroxy-2,3,9-trimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid, respectively.     

紫金龙属生物碱及其药理活性研究进展

紫金龙为罂粟科紫金龙属植物的根,是云南省多个地区,尤其是白族地区的传统药物。生物碱是该属植物的主要和特征性成分,具有调节心血管系统、镇痛、解痉、保肝、抗缺氧、抗疟等活性。对紫金龙属植物的传统药用价值、化学成分和药理活性进行归纳,以期为罂粟科紫金龙属植物生物碱的系统研究与应用提供有益的参考。